ANGP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANGP4_HUMAN
• UniProt AC: Q9Y264
• Protein Name: Angiopoietin-4
• Gene Name: ANGPT4
• Organism: Homo sapiens (Human).
• Sequence Length: 503
• Subcellular Localization: Secreted .
• Protein Description: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis..
• Protein Sequence: MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPEVSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQQQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQLLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERGLRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGASASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEHWLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQSSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIRWHYFKGPSYSLRASRMMIRPLDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSQLAMLQG -----CHHHHHHHHH	23.11	24043423
11	Phosphorylation	QLAMLQGSLLLVVAT HHHHHHHHHHHHHHH	11.68	24043423
18	Phosphorylation	SLLLVVATMSVAQQT HHHHHHHHHHHHHHH	9.81	24043423
20	Phosphorylation	LLVVATMSVAQQTRQ HHHHHHHHHHHHHHH	15.22	24043423
25	Phosphorylation	TMSVAQQTRQEADRG HHHHHHHHHHHHHCC	23.41	24043423
72	Phosphorylation	SNTLQRESLANPLHL CCCCCHHHCCCCHHH	34.66	46163225
96	N-linked_Glycosylation	QLEQALQNNTQWLKK HHHHHHHHCHHHHHH	55.13	UniProtKB CARBOHYD
126	N-linked_Glycosylation	VQQQMAQNQTAPMLE HHHHHHHCCCHHHHH	31.47	UniProtKB CARBOHYD
140	N-linked_Glycosylation	ELGTSLLNQTTAQIR HHHHHHHHHHHHHHH	42.31	UniProtKB CARBOHYD
150	Phosphorylation	TAQIRKLTDMEAQLL HHHHHHHHHHHHHHH	36.01	46163231
158	N-linked_Glycosylation	DMEAQLLNQTSRMDA HHHHHHHHHHCCHHC	52.23	UniProtKB CARBOHYD
215	Phosphorylation	KQQEELASILSKKAK HHHHHHHHHHHHHHH	36.37	24719451
226	Phosphorylation	KKAKLLNTLSRQSAA HHHHHHHHHHHHHHH	26.53	46163237
228	Phosphorylation	AKLLNTLSRQSAALT HHHHHHHHHHHHHHH	26.66	46163221
247	N-linked_Glycosylation	GLRGVRHNSSLLQDQ HHHHHHCCHHHHHHH	23.80	UniProtKB CARBOHYD
248	Phosphorylation	LRGVRHNSSLLQDQQ HHHHHCCHHHHHHHH	19.08	22817900
249	Phosphorylation	RGVRHNSSLLQDQQH HHHHCCHHHHHHHHH	38.11	22817900
274	N-linked_Glycosylation	HLVQERANASAPAFI HHHHHHHHCCCCCCH	40.42	UniProtKB CARBOHYD
311	N-linked_Glycosylation	VYTIQVSNATKPRKV EEEEEEECCCCCCEE	53.42	UniProtKB CARBOHYD
324	Phosphorylation	KVFCDLQSSGGRWTL EEEEEECCCCCCEEE	37.94	25954137
337	N-linked_Glycosylation	TLIQRRENGTVNFQR EEEEEECCCCCCEEE	50.01	UniProtKB CARBOHYD
377	Phosphorylation	LTRRAAYSLRVELQD HHHHHHHHEEEEEEC	12.65	24719451
427	N-linked_Glycosylation	QSSLVLQNTSFSTLD CCCEEEECCCCCCCC	33.26	UniProtKB CARBOHYD
490	Phosphorylation	YFKGPSYSLRASRMM EECCCCCCHHHHHEE	18.73	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANGP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANGP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANGP4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ANGP4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.