DCLK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCLK2_HUMAN
• UniProt AC: Q8N568
• Protein Name: Serine/threonine-protein kinase DCLK2
• Gene Name: DCLK2
• Organism: Homo sapiens (Human).
• Sequence Length: 766
• Subcellular Localization: Cytoplasm, cytoskeleton. Colocalizes with microtubules..
• Protein Description: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity)..
• Protein Sequence: MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MASTRSIELEHFE --CCCCCCEEHHHHH	22.09	22617229
29	Phosphorylation	GSRRGAPSSSGGSSS CCCCCCCCCCCCCCC	36.28	22210691
30	Phosphorylation	SRRGAPSSSGGSSSS CCCCCCCCCCCCCCC	31.76	21955146
31	Phosphorylation	RRGAPSSSGGSSSSG CCCCCCCCCCCCCCC	52.06	21955146
34	Phosphorylation	APSSSGGSSSSGPKG CCCCCCCCCCCCCCC	30.49	21955146
35	Phosphorylation	PSSSGGSSSSGPKGN CCCCCCCCCCCCCCC	31.62	22210691
36	Phosphorylation	SSSGGSSSSGPKGNG CCCCCCCCCCCCCCC	40.80	21955146
37	Phosphorylation	SSGGSSSSGPKGNGL CCCCCCCCCCCCCCC	62.15	21955146
47	Phosphorylation	KGNGLIPSPAHSAHC CCCCCCCCCCHHHCC	27.94	28555341
51	Phosphorylation	LIPSPAHSAHCSFYR CCCCCCHHHCCCHHH	23.09	21955146
55	Phosphorylation	PAHSAHCSFYRTRTL CCHHHCCCHHHHHHH	18.55	21955146
57	Phosphorylation	HSAHCSFYRTRTLQA HHHCCCHHHHHHHHH	8.52	21955146
59	Phosphorylation	AHCSFYRTRTLQALS HCCCHHHHHHHHHHC	19.34	28857561
61	Phosphorylation	CSFYRTRTLQALSSE CCHHHHHHHHHHCCH	23.70	25884760
66	Phosphorylation	TRTLQALSSEKKAKK HHHHHHHCCHHHHHH	39.19	28674419
83	Phosphorylation	FYRNGDRYFKGLVFA HHCCCCHHCCCEEEE	17.87	-
93	Phosphorylation	GLVFAISSDRFRSFD CEEEEECCCCCCCHH	27.05	-
98	Phosphorylation	ISSDRFRSFDALLIE ECCCCCCCHHHHHHH	25.43	24719451
166	Phosphorylation	KNINPNWSVNIKGGT CCCCCCCEEEECCHH	16.36	24076635
173	Phosphorylation	SVNIKGGTSRALAAA EEEECCHHHHHHHHH	24.57	-
182	Phosphorylation	RALAAASSVKSEVKE HHHHHHHHCHHHHHH	28.92	28857561
184	Ubiquitination	LAAASSVKSEVKESK HHHHHHCHHHHHHCC	42.73	30230243
185	Phosphorylation	AAASSVKSEVKESKD HHHHHCHHHHHHCCC	45.53	28857561
190	Phosphorylation	VKSEVKESKDFIKPK CHHHHHHCCCCCCHH	31.63	22964224
220	Phosphorylation	RILLNKKTAHSFEQV HHHCCCCCCCCHHHH	31.08	27732954
223	Phosphorylation	LNKKTAHSFEQVLTD CCCCCCCCHHHHHHH	28.19	27732954
293	Phosphorylation	SECRVLKSSYSRSSA HHHEEEECCCCCCCC	30.28	22210691
294	Phosphorylation	ECRVLKSSYSRSSAV HHEEEECCCCCCCCC	26.07	22210691
295	Phosphorylation	CRVLKSSYSRSSAVK HEEEECCCCCCCCCC	18.39	29449344
296	Phosphorylation	RVLKSSYSRSSAVKY EEEECCCCCCCCCCC	27.86	29449344
298	Phosphorylation	LKSSYSRSSAVKYSG EECCCCCCCCCCCCC	19.40	22964224
299	Phosphorylation	KSSYSRSSAVKYSGS ECCCCCCCCCCCCCC	35.65	29449344
303	Phosphorylation	SRSSAVKYSGSKSPG CCCCCCCCCCCCCCC	16.21	22912867
304	Phosphorylation	RSSAVKYSGSKSPGP CCCCCCCCCCCCCCC	30.76	29449344
306	Phosphorylation	SAVKYSGSKSPGPSR CCCCCCCCCCCCCCC	24.82	22964224
308	Phosphorylation	VKYSGSKSPGPSRRS CCCCCCCCCCCCCCC	36.46	22912867
312	Phosphorylation	GSKSPGPSRRSKSPA CCCCCCCCCCCCCCC	46.36	29449344
315	Phosphorylation	SPGPSRRSKSPASVN CCCCCCCCCCCCCCC	36.05	20363803
317	Phosphorylation	GPSRRSKSPASVNGT CCCCCCCCCCCCCCC	27.26	25159151
320	Phosphorylation	RRSKSPASVNGTPSS CCCCCCCCCCCCCHH	21.35	22210691
324	Phosphorylation	SPASVNGTPSSQLST CCCCCCCCCHHHCCC	18.13	20363803
326	Phosphorylation	ASVNGTPSSQLSTPK CCCCCCCHHHCCCCC	30.47	27251275
327	Phosphorylation	SVNGTPSSQLSTPKS CCCCCCHHHCCCCCC	36.02	27251275
330	Phosphorylation	GTPSSQLSTPKSTKS CCCHHHCCCCCCCCC	34.72	28985074
331	Phosphorylation	TPSSQLSTPKSTKSS CCHHHCCCCCCCCCC	43.24	-
334	Phosphorylation	SQLSTPKSTKSSSSS HHCCCCCCCCCCCCC	42.12	22210691
335	Phosphorylation	QLSTPKSTKSSSSSP HCCCCCCCCCCCCCC	40.86	22210691
336 (in isoform 3)	Phosphorylation	-	56.27	22210691
337	Phosphorylation	STPKSTKSSSSSPTS CCCCCCCCCCCCCCC	35.22	30576142
338	Phosphorylation	TPKSTKSSSSSPTSP CCCCCCCCCCCCCCC	35.48	22199227
339	Phosphorylation	PKSTKSSSSSPTSPG CCCCCCCCCCCCCCC	41.76	30576142
340	Phosphorylation	KSTKSSSSSPTSPGS CCCCCCCCCCCCCCC	42.14	30576142
341 (in isoform 3)	Phosphorylation	-	33.86	28985074
341	Phosphorylation	STKSSSSSPTSPGSF CCCCCCCCCCCCCCC	33.86	22199227
343	Phosphorylation	KSSSSSPTSPGSFRG CCCCCCCCCCCCCCC	49.88	22199227
344	Phosphorylation	SSSSSPTSPGSFRGL CCCCCCCCCCCCCCC	30.55	22199227
347 (in isoform 2)	Phosphorylation	-	18.36	28842319
347	Phosphorylation	SSPTSPGSFRGLKQI CCCCCCCCCCCCEEE	18.36	20886841
348 (in isoform 3)	Phosphorylation	-	9.96	24076635
355	Phosphorylation	FRGLKQISAHGRSSS CCCCEEEECCCCCCC	16.24	23312004
358	Phosphorylation	LKQISAHGRSSSNVN CEEEECCCCCCCCCC	30.77	24719451
360	Phosphorylation	QISAHGRSSSNVNGG EEECCCCCCCCCCCC	42.59	21955146
361	Phosphorylation	ISAHGRSSSNVNGGP EECCCCCCCCCCCCC	25.27	28450419
362	Phosphorylation	SAHGRSSSNVNGGPE ECCCCCCCCCCCCCC	46.15	25159151
364	Phosphorylation	HGRSSSNVNGGPELD CCCCCCCCCCCCCCC	8.33	27251275
372	Phosphorylation	NGGPELDRCISPEGV CCCCCCCCCCCCCCC	32.09	24719451
375	Phosphorylation	PELDRCISPEGVNGN CCCCCCCCCCCCCCC	22.11	28450419
377	Phosphorylation	LDRCISPEGVNGNRC CCCCCCCCCCCCCCC	69.82	27251275
379	Phosphorylation	RCISPEGVNGNRCSE CCCCCCCCCCCCCCC	8.70	27251275
392	Phosphorylation	SESSTLLEKYKIGKV CCCCHHHHHHCCCEE	58.41	27251275
398	Ubiquitination	LEKYKIGKVIGDGNF HHHHCCCEEECCCCE	33.87	30230243
409	Ubiquitination	DGNFAVVKECIDRST CCCEEEEEHHHHCCC	40.02	29967540
415	Ubiquitination	VKECIDRSTGKEFAL EEHHHHCCCCCCHHH	37.45	30230243
426	Ubiquitination	EFALKIIDKAKCCGK CHHHHHHHHHHHCCC	48.62	29967540
486	Ubiquitination	DAITSSTKYTERDGS HHHHCCCCCCCCCCC	52.72	30230243
503	Ubiquitination	VYNLANALRYLHGLS HHHHHHHHHHHHCCC	3.57	30230243
505	Phosphorylation	NLANALRYLHGLSIV HHHHHHHHHHCCCEE	12.14	25884760
647	Phosphorylation	CTAGQILSHPWVSDD CCCCCHHCCCCCCCC	29.18	-
666	Phosphorylation	NNMQAEVTGKLKQHF CCHHHHHHHHHHHHH	21.80	-
682	Phosphorylation	NALPKQNSTTTGVSV HCCCCCCCCCCCCEE	25.33	21712546
683	Phosphorylation	ALPKQNSTTTGVSVI CCCCCCCCCCCCEEE	35.61	28348404
684	Phosphorylation	LPKQNSTTTGVSVIM CCCCCCCCCCCEEEE	22.75	28348404
685	Phosphorylation	PKQNSTTTGVSVIMN CCCCCCCCCCEEEEC	35.36	27251275
702	Phosphorylation	LDKEGQIFCSKHCQD CCCCCCEEECHHCCC	2.71	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCLK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCLK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCLK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
T22D3_HUMAN	TSC22D3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.