PRAG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRAG1_HUMAN
• UniProt AC: Q86YV5
• Protein Name: Tyrosine-protein kinase PRAG1 {ECO:0000312|HGNC:HGNC:25438}
• Gene Name: PRAG1 {ECO:0000312|HGNC:HGNC:25438}
• Organism: Homo sapiens (Human).
• Sequence Length: 1406
• Protein Sequence: MHQTLCLNPESLKMSACSDFVEHIWKPGSCKNCFCLRSDHQLVAGPPQPRAGSLPPPPRLPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQSLARLVAKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSTYAVKICKAPEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSSMLSSPDAPKDPVPALPTHPPAQEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVQQPGTSEEALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLCCQYLASAEPGALLQSLKLLQLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	PPQPRAGSLPPPPRL CCCCCCCCCCCCCCC		27251275
77	Phosphorylation	EDEGVNSSPYSKPTI CCCCCCCCCCCCCEE		25627689
79	Phosphorylation	EGVNSSPYSKPTIAV CCCCCCCCCCCEEEE		20736484
132	Phosphorylation	QEDAPVVYLGSFRGV CCCCCEEEEECCCCC		21945579
135	Phosphorylation	APVVYLGSFRGVQKP CCEEEEECCCCCCCC		21945579
146	Phosphorylation	VQKPAGPSTSPDGNS CCCCCCCCCCCCCCC		30266825
147	Phosphorylation	QKPAGPSTSPDGNSR CCCCCCCCCCCCCCC		30266825
148	Phosphorylation	KPAGPSTSPDGNSRC CCCCCCCCCCCCCCC		30266825
153	Phosphorylation	STSPDGNSRCPPAYT CCCCCCCCCCCCCCE		30206219
159	Phosphorylation	NSRCPPAYTMVGLHN CCCCCCCCEEEEEEC		27273156
160	Phosphorylation	SRCPPAYTMVGLHNL CCCCCCCEEEEEECC		27259358
197	Phosphorylation	KEKPSFPYQDRPSTQ CCCCCCCCCCCCCHH		-
202	Phosphorylation	FPYQDRPSTQESFRQ CCCCCCCCHHHHHHH		28348404
203	Phosphorylation	PYQDRPSTQESFRQK CCCCCCCHHHHHHHH		22322096
206	Phosphorylation	DRPSTQESFRQKLAA CCCCHHHHHHHHHHH		28348404
217	Phosphorylation	KLAAFAGTTSGCHQG HHHHHHCCCCCCCCC		28348404
218	Phosphorylation	LAAFAGTTSGCHQGP HHHHHCCCCCCCCCC		28348404
219	Phosphorylation	AAFAGTTSGCHQGPG HHHHCCCCCCCCCCC		28348404
231	Phosphorylation	GPGPLRESLPSEDDS CCCCHHHCCCCCCCC		27422710
234	Phosphorylation	PLRESLPSEDDSDQR CHHHCCCCCCCCCCC		21815630
238	Phosphorylation	SLPSEDDSDQRCSPS CCCCCCCCCCCCCCC		27251275
243	Phosphorylation	DDSDQRCSPSGDSEG CCCCCCCCCCCCCCC		26657352
245	Phosphorylation	SDQRCSPSGDSEGGE CCCCCCCCCCCCCCC		28348404
248	Phosphorylation	RCSPSGDSEGGEYCS CCCCCCCCCCCCEEE		28348404
253	Phosphorylation	GDSEGGEYCSILDCC CCCCCCCEEEEEECC		25884760
255	Phosphorylation	SEGGEYCSILDCCPG CCCCCEEEEEECCCC		22210691
263	Phosphorylation	ILDCCPGSPVAKAAS EEECCCCCHHHHHHH		18180459
285	Phosphorylation	RHGGRDCSPTCWEQG CCCCCCCCCCHHHCC		25159151
287	Phosphorylation	GGRDCSPTCWEQGKC CCCCCCCCHHHCCCC		23663014
306	Phosphorylation	EQEKRGPSFPKECCS HHHHCCCCCCHHHHC		-
313	Phosphorylation	SFPKECCSQGPTAHP CCCHHHHCCCCCCCH		-
317	Phosphorylation	ECCSQGPTAHPSCLG HHHCCCCCCCHHHCC		-
321	Phosphorylation	QGPTAHPSCLGPKKL CCCCCCHHHCCCCCC		-
347	Phosphorylation	GLSCGSGSGSGSGAS CCCCCCCCCCCCCCC		24275569
351	Phosphorylation	GSGSGSGSGASSPFV CCCCCCCCCCCCCCC		24275569
363	Phosphorylation	PFVPHLESDYCSLMK CCCCCCCCCCHHHCC		20736484
365	Phosphorylation	VPHLESDYCSLMKEP CCCCCCCCHHHCCCC		-
384	Phosphorylation	QQDPGCPGVTPSRCL HCCCCCCCCCHHHHC		-
386	Phosphorylation	DPGCPGVTPSRCLGL CCCCCCCCHHHHCCC		21815630
407	Phosphorylation	PAHPREATQPEPIYA CCCCCCCCCCCCCCC		28796482
411	Phosphorylation	REATQPEPIYAESTK CCCCCCCCCCCCCCC		18083107
413	Phosphorylation	ATQPEPIYAESTKRK CCCCCCCCCCCCCCC		27273156
416	Phosphorylation	PEPIYAESTKRKKAA CCCCCCCCCCCCCCC		30266825
417	Phosphorylation	EPIYAESTKRKKAAP CCCCCCCCCCCCCCC		30266825
457	Phosphorylation	AWAQKAASGWGRDSP HHHHHHHCCCCCCCC		27251275
461	Phosphorylation	KAASGWGRDSPDPTP HHHCCCCCCCCCCCC		24719451
463	Phosphorylation	ASGWGRDSPDPTPQV HCCCCCCCCCCCCCE		28985074
471	Phosphorylation	PDPTPQVSATITVMA CCCCCCEEEEEEEEE		22210691
475	Phosphorylation	PQVSATITVMAAHPE CCEEEEEEEEECCCC		22210691
487	Phosphorylation	HPEEDHRTIYLSSPD CCCCCCCEEEECCCC		28152594
489	Phosphorylation	EEDHRTIYLSSPDSA CCCCCEEEECCCCCC		28152594
490	Phosphorylation	EDHRTIYLSSPDSAV CCCCEEEECCCCCCC		-
491	Phosphorylation	DHRTIYLSSPDSAVG CCCEEEECCCCCCCC		28152594
492	Phosphorylation	HRTIYLSSPDSAVGV CCEEEECCCCCCCCC		25159151
493	Phosphorylation	RTIYLSSPDSAVGVQ CEEEECCCCCCCCCC		-
495	Phosphorylation	IYLSSPDSAVGVQWP EEECCCCCCCCCCCC		22199227
505	Phosphorylation	GVQWPRGPVSQNSEV CCCCCCCCCCCCCCC		-
507	Phosphorylation	QWPRGPVSQNSEVGE CCCCCCCCCCCCCCC		25159151
508	Phosphorylation	WPRGPVSQNSEVGEE CCCCCCCCCCCCCCC		24719451
510	Phosphorylation	RGPVSQNSEVGEEET CCCCCCCCCCCCCCC		25159151
515	Phosphorylation	QNSEVGEEETSAGQG CCCCCCCCCCCCCCC		-
517	Phosphorylation	SEVGEEETSAGQGLS CCCCCCCCCCCCCCC		23836654
610	Phosphorylation	GVAISDPSRCPQPAA CEECCCHHHCCCCCC		-
618	Phosphorylation	RCPQPAASSASEQRR HCCCCCCCCHHHHCC		28555341
630	Phosphorylation	QRRPRFQAGTWSRQC HCCHHHCCCCCCCCC		24719451
632	Phosphorylation	RPRFQAGTWSRQCRI CHHHCCCCCCCCCCC		23312004
649	Phosphorylation	EEEVEQELLSHSWGR HHHHHHHHHHCCCCC		-
651	Phosphorylation	EVEQELLSHSWGRET HHHHHHHHCCCCCCC		30266825
653	Phosphorylation	EQELLSHSWGRETKN HHHHHHCCCCCCCCC		30266825
658	Phosphorylation	SHSWGRETKNGPTDH HCCCCCCCCCCCCCC		30624053
666	Phosphorylation	KNGPTDHSNSTTWHR CCCCCCCCCCCCCEE		-
668	Phosphorylation	GPTDHSNSTTWHRLH CCCCCCCCCCCEECC		27251275
677	Phosphorylation	TWHRLHPTDGSSGQN CCEECCCCCCCCCCC		27794612
680	Phosphorylation	RLHPTDGSSGQNSKV ECCCCCCCCCCCCCC		27794612
681	Phosphorylation	LHPTDGSSGQNSKVG CCCCCCCCCCCCCCC		27794612
686	Acetylation	GSSGQNSKVGTGMSK CCCCCCCCCCCCCCC		19811819
692	Phosphorylation	SKVGTGMSKSASFAF CCCCCCCCCCCEEEE		18669648
693	Acetylation	KVGTGMSKSASFAFE CCCCCCCCCCEEEEE		19811829
694	Phosphorylation	VGTGMSKSASFAFEF CCCCCCCCCEEEEEC		23401153
696	Phosphorylation	TGMSKSASFAFEFPK CCCCCCCEEEEECCC		23927012
706	Phosphorylation	FEFPKDRSGIETFSP EECCCCCCCCCCCCC		26657352
708	Phosphorylation	FPKDRSGIETFSPPP CCCCCCCCCCCCCCC		-
710	Phosphorylation	KDRSGIETFSPPPPP CCCCCCCCCCCCCCC		30266825
712	Phosphorylation	RSGIETFSPPPPPPK CCCCCCCCCCCCCCC		30266825
727	Phosphorylation	SRHLLKMNKSSSDLE HHHHHHCCCCHHHHH		24719451
728	Phosphorylation	RHLLKMNKSSSDLEK HHHHHCCCCHHHHHH		-
729	Phosphorylation	HLLKMNKSSSDLEKV HHHHCCCCHHHHHHH		26657352
730	Phosphorylation	LLKMNKSSSDLEKVS HHHCCCCHHHHHHHH		26657352
731	Phosphorylation	LKMNKSSSDLEKVSQ HHCCCCHHHHHHHHH		23403867
735	Phosphorylation	KSSSDLEKVSQGSAE CCHHHHHHHHHCCHH		-
737	Phosphorylation	SSDLEKVSQGSAESL HHHHHHHHHCCHHHC		27794612
738	Phosphorylation	SDLEKVSQGSAESLS HHHHHHHHCCHHHCC		24719451
740	Phosphorylation	LEKVSQGSAESLSPS HHHHHHCCHHHCCCC		29255136
741	Phosphorylation	EKVSQGSAESLSPSF HHHHHCCHHHCCCCC		21406692
743	Phosphorylation	VSQGSAESLSPSFRG HHHCCHHHCCCCCCE		19664994
745	Phosphorylation	QGSAESLSPSFRGVH HCCHHHCCCCCCEEE		29255136
747	Phosphorylation	SAESLSPSFRGVHVS CHHHCCCCCCEEEEE		30266825
754	Phosphorylation	SFRGVHVSFTTGSTD CCCEEEEEEECCCCC		28464451
756	Phosphorylation	RGVHVSFTTGSTDSL CEEEEEEECCCCCCH		28450419
757	Phosphorylation	GVHVSFTTGSTDSLA EEEEEEECCCCCCHH		28450419
759	Phosphorylation	HVSFTTGSTDSLASD EEEEECCCCCCHHCC		25159151
760	Phosphorylation	VSFTTGSTDSLASDS EEEECCCCCCHHCCC		28464451
762	Phosphorylation	FTTGSTDSLASDSRT EECCCCCCHHCCCCC		30576142
765	Phosphorylation	GSTDSLASDSRTCSD CCCCCHHCCCCCCCC		28450419
767	Phosphorylation	TDSLASDSRTCSDGG CCCHHCCCCCCCCCC		26699800
769	Phosphorylation	SLASDSRTCSDGGPS CHHCCCCCCCCCCCH		23403867
771	Phosphorylation	ASDSRTCSDGGPSSE HCCCCCCCCCCCHHH		23403867
774	Phosphorylation	SRTCSDGGPSSELAH CCCCCCCCCHHHHCC		-
776	Phosphorylation	TCSDGGPSSELAHSP CCCCCCCHHHHCCCC		21712546
777	Phosphorylation	CSDGGPSSELAHSPT CCCCCCHHHHCCCCC		30206219
780	Phosphorylation	GGPSSELAHSPTNSG CCCHHHHCCCCCCCC		24719451
782	Phosphorylation	PSSELAHSPTNSGKK CHHHHCCCCCCCCCC		23401153
784	Phosphorylation	SELAHSPTNSGKKLF HHHCCCCCCCCCCEE		30278072
786	Phosphorylation	LAHSPTNSGKKLFAP HCCCCCCCCCCEEEE		25159151
796	Phosphorylation	KLFAPVPFPSGSTED CEEEECCCCCCCCCC		-
798	Phosphorylation	FAPVPFPSGSTEDVS EEECCCCCCCCCCCC		23401153
800	Phosphorylation	PVPFPSGSTEDVSPS ECCCCCCCCCCCCCC		30278072
801	Phosphorylation	VPFPSGSTEDVSPSG CCCCCCCCCCCCCCC		21712546
803	Phosphorylation	FPSGSTEDVSPSGPQ CCCCCCCCCCCCCCC		24719451
805	Phosphorylation	SGSTEDVSPSGPQQP CCCCCCCCCCCCCCC		21712546
807	Phosphorylation	STEDVSPSGPQQPPP CCCCCCCCCCCCCCC		28450419
822	Phosphorylation	LPQKKIVSRAASSPD CCCHHHHCCCCCCCC		29514088
824	Phosphorylation	QKKIVSRAASSPDGF CHHHHCCCCCCCCCC		24719451
825	Phosphorylation	KKIVSRAASSPDGFF HHHHCCCCCCCCCCC		21406692
826	Phosphorylation	KIVSRAASSPDGFFW HHHCCCCCCCCCCCC		23401153
827	Phosphorylation	IVSRAASSPDGFFWT HHCCCCCCCCCCCCC		30266825
834	Phosphorylation	SPDGFFWTQGSPKPG CCCCCCCCCCCCCCC		30266825
835	Phosphorylation	PDGFFWTQGSPKPGT CCCCCCCCCCCCCCC		24719451
837	Phosphorylation	GFFWTQGSPKPGTAS CCCCCCCCCCCCCCC		23927012
840	Phosphorylation	WTQGSPKPGTASPKL CCCCCCCCCCCCCCC		-
842	Phosphorylation	QGSPKPGTASPKLNL CCCCCCCCCCCCCCC		23401153
844	Phosphorylation	SPKPGTASPKLNLSH CCCCCCCCCCCCCCC		23927012
850	Phosphorylation	ASPKLNLSHSETNVH CCCCCCCCCCCCCCC		29496963
852	Phosphorylation	PKLNLSHSETNVHDE CCCCCCCCCCCCCCC		28464451
854	Phosphorylation	LNLSHSETNVHDESH CCCCCCCCCCCCCCC		25849741
860	Phosphorylation	ETNVHDESHFSYSLS CCCCCCCCCCEEECC		26657352
863	Phosphorylation	VHDESHFSYSLSPGN CCCCCCCEEECCCCC		28152594
864	Phosphorylation	HDESHFSYSLSPGNR CCCCCCEEECCCCCC		28152594
865	Phosphorylation	DESHFSYSLSPGNRH CCCCCEEECCCCCCC		27273156
867	Phosphorylation	SHFSYSLSPGNRHHP CCCEEECCCCCCCCC		28152594
875	Phosphorylation	PGNRHHPVFSSSDPL CCCCCCCCCCCCCHH		24719451
876	Phosphorylation	GNRHHPVFSSSDPLE CCCCCCCCCCCCHHH		21406692
877	Phosphorylation	NRHHPVFSSSDPLEK CCCCCCCCCCCHHHH		27794612
878	Phosphorylation	RHHPVFSSSDPLEKA CCCCCCCCCCHHHHH		23401153
879	Phosphorylation	HHPVFSSSDPLEKAF CCCCCCCCCHHHHHH		27794612
887	Phosphorylation	DPLEKAFKGSGHWLP CHHHHHHCCCCCCCC		24719451
889	Phosphorylation	LEKAFKGSGHWLPAA HHHHHCCCCCCCCCC		23401153
905	Phosphorylation	LAGNRGGCGSPGLQC CCCCCCCCCCCCCCC		24719451
907	Phosphorylation	GNRGGCGSPGLQCKG CCCCCCCCCCCCCCC		25159151
959	Phosphorylation	YAKLGGLYTQSLARL CCCCCHHHHHHHHHH		27642862
990	Phosphorylation	HFNENNWSLFKLTCN EECCCCEEEEEEEEC		24719451
1223	Phosphorylation	NFLKAKQKPGGTPNL HHHHHHCCCCCCCCH		24719451
1227	Phosphorylation	AKQKPGGTPNLQQKK HHCCCCCCCCHHHHH		25159151
1361	Acetylation	WIDMKRALMMMKFAE HHHHHHHHHHHHHHH		-
1365	Acetylation	KRALMMMKFAEKAVD HHHHHHHHHHHHHHH		19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRAG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRAG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRAG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCG1_HUMAN	CHGB	physical	16169070
SAP_HUMAN	PSAP	physical	16169070

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.