PLCE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCE1_HUMAN
• UniProt AC: Q9P212
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
• Gene Name: PLCE1
• Organism: Homo sapiens (Human).
• Sequence Length: 2302
• Subcellular Localization: Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation..
• Protein Sequence: MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKLKEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQRQFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHPDSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMELAKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHFEDFPDNCDDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTAWSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRREETENTVGSLLHFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSEEMTAS ------CCCHHHHHH	57.03	27050516
9	Phosphorylation	TSEEMTASVLIPVTQ CCHHHHHHEEEEECC	14.32	27050516
15	Phosphorylation	ASVLIPVTQRKVVSA HHEEEEECCCCCCCC	19.80	27050516
50	Phosphorylation	TVRRSGETSHTISQL CCCCCCCCCCHHHHH	29.36	29083192
51	Phosphorylation	VRRSGETSHTISQLN CCCCCCCCCHHHHHH	17.84	23532336
53	Phosphorylation	RSGETSHTISQLNKL CCCCCCCHHHHHHHH	23.30	23532336
55	Phosphorylation	GETSHTISQLNKLKE CCCCCHHHHHHHHCC	29.75	29083192
65	Phosphorylation	NKLKEEPSGSNLPKI HHHCCCCCCCCHHHH	59.12	-
67	Phosphorylation	LKEEPSGSNLPKILS HCCCCCCCCHHHHHH	39.26	-
74	Phosphorylation	SNLPKILSIAREKIV CCHHHHHHHHHHHHC	20.06	-
198	Phosphorylation	YEVDRRMSDTFCTLS HHHCCCCCCCCCCCC	31.52	28348404
200	Phosphorylation	VDRRMSDTFCTLSEN HCCCCCCCCCCCCCC	17.19	28348404
203	Phosphorylation	RMSDTFCTLSENLIL CCCCCCCCCCCCEEE	29.18	28348404
362	Phosphorylation	HIGLTAWSYIDQKRN CCEEEEHHHHHCCCC	15.11	-
485	Phosphorylation	GARSGLLSTFGGSTG CCCCCHHHHCCCHHH	27.08	28348404
486	Phosphorylation	ARSGLLSTFGGSTGR CCCCHHHHCCCHHHC	26.69	28857561
490	Phosphorylation	LLSTFGGSTGRMMLK HHHHCCCHHHCEEEE	28.24	19664994
491	Phosphorylation	LSTFGGSTGRMMLKE HHHCCCHHHCEEEEC	31.89	22199227
576	Acetylation	QSSLPCLKASISASI HCCCHHHHHHHEEEE	46.97	20167786
666	Phosphorylation	MWQFMDQSDIETMRS HHHCCCHHHHHHHHH	35.97	30576142
670	Phosphorylation	MDQSDIETMRSLKDA CCHHHHHHHHHHHHH	20.44	30576142
761	Phosphorylation	GQNGLKNSEKESTVN HHCCCCCCCCCHHHH	48.75	-
780	Phosphorylation	VIRSCNRSLETDEED HHHHCCCCCCCCCCC	19.30	24114839
783	Phosphorylation	SCNRSLETDEEDSPS HCCCCCCCCCCCCCC	54.74	24719451
788	Phosphorylation	LETDEEDSPSEGNSS CCCCCCCCCCCCCCC	33.34	24719451
790	Phosphorylation	TDEEDSPSEGNSSRK CCCCCCCCCCCCCCH	63.19	24114839
794	Phosphorylation	DSPSEGNSSRKSSLK CCCCCCCCCCHHHCC	42.23	24719451
795	Phosphorylation	SPSEGNSSRKSSLKD CCCCCCCCCHHHCCC	47.96	24114839
994	Phosphorylation	HFVAPKHTAKMLFSG EHHCCHHHHHHHHHH	33.81	28348404
1000	Phosphorylation	HTAKMLFSGLLELTR HHHHHHHHHHHHHHH	25.27	28348404
1006	Phosphorylation	FSGLLELTRAVRKMR HHHHHHHHHHHHHHH	13.75	28348404
1060	Phosphorylation	RWSARNPSPGTSAKN CCCCCCCCCCCCCCC	39.24	28102081
1063	Phosphorylation	ARNPSPGTSAKNAEK CCCCCCCCCCCCCCC	28.97	28102081
1064	Phosphorylation	RNPSPGTSAKNAEKP CCCCCCCCCCCCCCC	43.06	28102081
1084	Phosphorylation	NTLGISTTKKKKKIL CCCCCCCCCCCCEEE	33.79	22468782
1096	Phosphorylation	KILMRGESGEVTDDE EEEECCCCCCCCCHH	42.98	26657352
1100	Phosphorylation	RGESGEVTDDEMATR CCCCCCCCCHHHHHH	33.17	29523821
1119	Phosphorylation	HKECRSRSGSDPQDI HHHHHHCCCCCHHHC	43.85	24719451
1121	Phosphorylation	ECRSRSGSDPQDINE HHHHCCCCCHHHCCH	47.57	24114839
1151	Phosphorylation	LPSRRAHSLTTAGSP CCCCCCCCCCCCCCC	26.82	28348404
1153	Phosphorylation	SRRAHSLTTAGSPNL CCCCCCCCCCCCCCC	20.02	28348404
1154	Phosphorylation	RRAHSLTTAGSPNLA CCCCCCCCCCCCCCC	34.02	28348404
1157	Phosphorylation	HSLTTAGSPNLAAGT CCCCCCCCCCCCCCC	14.25	28348404
1164	Phosphorylation	SPNLAAGTSSPIRPV CCCCCCCCCCCCCCC	22.70	28348404
1165	Phosphorylation	PNLAAGTSSPIRPVS CCCCCCCCCCCCCCC	32.95	28348404
1166	Phosphorylation	NLAAGTSSPIRPVSS CCCCCCCCCCCCCCC	24.96	28348404
1172	Phosphorylation	SSPIRPVSSPVLSSS CCCCCCCCCCCCCCC	31.44	28348404
1173	Phosphorylation	SPIRPVSSPVLSSSN CCCCCCCCCCCCCCC	21.18	28348404
1177	Phosphorylation	PVSSPVLSSSNKSPS CCCCCCCCCCCCCCC	31.77	23312004
1178	Phosphorylation	VSSPVLSSSNKSPSS CCCCCCCCCCCCCCC	33.50	23312004
1179	Phosphorylation	SSPVLSSSNKSPSSA CCCCCCCCCCCCCCC	44.92	23312004
1188	Phosphorylation	KSPSSAWSSSSWHGR CCCCCCCCCCCCCCC	21.76	28857561
1189	Phosphorylation	SPSSAWSSSSWHGRI CCCCCCCCCCCCCCC	20.07	28857561
1190	Phosphorylation	PSSAWSSSSWHGRIK CCCCCCCCCCCCCCC	31.75	28857561
1191	Phosphorylation	SSAWSSSSWHGRIKG CCCCCCCCCCCCCCC	25.66	28857561
1259	Phosphorylation	APLYTNLTIDENTSD CCEEEEEEECCCCCC	28.58	-
1356	Phosphorylation	IIQKFEPSISMCHQG HHHHHCCCHHHHHCC	21.79	24667141
1366	Phosphorylation	MCHQGLMSFEGFARF HHHCCCCCHHHHHHH	25.78	24667141
1400	Phosphorylation	ELQLPLSYYYIESSH HCCCCCEEEEEECCC	14.15	22817900
1401	Phosphorylation	LQLPLSYYYIESSHN CCCCCEEEEEECCCC	8.45	22817900
1402	Phosphorylation	QLPLSYYYIESSHNT CCCCEEEEEECCCCE	7.03	22817900
1472	Phosphorylation	VVEAIDRSAFINSDL HHHHHCHHHHCCCCC	24.63	23403867
1477	Phosphorylation	DRSAFINSDLPIIIS CHHHHCCCCCCEEEE	35.39	23403867
1541	Methylation	KVLLKNKKLKAHQTP HHHHHCCCCCCCCCH	65.69	23644510
1555	Methylation	PVDILKQKAHQLASM HHHHHHHHHHHHHHC	46.37	23644510
1595	Phosphorylation	EYDYDYESLSDDNIL CCCCCHHHCCCCCCC	27.26	-
1597	Phosphorylation	DYDYESLSDDNILED CCCHHHCCCCCCCCC	52.80	-
1682	Phosphorylation	VKFPGLSTLNASGSS CCCCCCCCCCCCCCC	29.13	24719451
1686	Phosphorylation	GLSTLNASGSSRGKE CCCCCCCCCCCCCCC	37.83	29514088
1688	Phosphorylation	STLNASGSSRGKERK CCCCCCCCCCCCCCC	17.86	29514088
1689	Phosphorylation	TLNASGSSRGKERKS CCCCCCCCCCCCCCC	48.88	29514088
1699	Phosphorylation	KERKSRKSIFGNNPG CCCCCCCCCCCCCCC	23.26	27251275
1709	Phosphorylation	GNNPGRMSPGETASF CCCCCCCCCCCCCCC	28.52	22199227
1713	Phosphorylation	GRMSPGETASFNKTS CCCCCCCCCCCCCCC	33.25	22199227
1715	Phosphorylation	MSPGETASFNKTSGK CCCCCCCCCCCCCCC	36.45	29523821
1720	Phosphorylation	TASFNKTSGKSSCEG CCCCCCCCCCCCCHH	45.92	17494752
1735	Phosphorylation	IRQTWEESSSPLNPT HHHHHHCCCCCCCCC	25.30	28348404
1736	Phosphorylation	RQTWEESSSPLNPTT HHHHHCCCCCCCCCC	38.97	24719451
1737	Phosphorylation	QTWEESSSPLNPTTS HHHHCCCCCCCCCCC	42.56	28348404
1744	Phosphorylation	SPLNPTTSLSAIIRT CCCCCCCCHHHHHCC	23.86	22210691
1746	Phosphorylation	LNPTTSLSAIIRTPK CCCCCCHHHHHCCCC	19.72	22210691
1751	Phosphorylation	SLSAIIRTPKCYHIS CHHHHHCCCCCEECC	19.38	22210691
1979	Phosphorylation	HNEVLEISSLFINSR CHHHHHHHHHHCCCC	16.18	22210691
1980	Phosphorylation	NEVLEISSLFINSRR HHHHHHHHHHCCCCC	32.72	22210691
1992	Phosphorylation	SRRMEENSSGNTMSA CCCCCCCCCCCCCCH	42.79	22210691
1993	Phosphorylation	RRMEENSSGNTMSAS CCCCCCCCCCCCCHH	47.87	22210691
2000	Phosphorylation	SGNTMSASSMFNTEE CCCCCCHHHHCCHHH	18.28	-
2005	Phosphorylation	SASSMFNTEERKCLQ CHHHHCCHHHHHHHH	28.14	-
2159	O-linked_Glycosylation	VIKAPRVSTAQDVIQ EEECCCCCCHHHHHH	21.21	28657654
2160	Phosphorylation	IKAPRVSTAQDVIQQ EECCCCCCHHHHHHH	26.02	24667141
2273	Phosphorylation	PRGLTSPSQLLTSES CCCCCCHHHHHCCCC	32.97	26657352
2295	Phosphorylation	PVGGLSSSDTMDYRQ CCCCCCCCCCCCCCC	33.45	19053533
2297	Phosphorylation	GGLSSSDTMDYRQ-- CCCCCCCCCCCCC--	17.56	19053533

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RASN_HUMAN	NRAS	physical	16169070
SIAH2_HUMAN	SIAH2	physical	17998205

Drug and Disease Associations

• Kegg Disease
• H00626: Nephrotic syndrome and focal segmental glomerulosclerosis
• OMIM Disease
• 610725: Nephrotic syndrome 3 (NPHS3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.