KLH34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH34_HUMAN
• UniProt AC: Q8N239
• Protein Name: Kelch-like protein 34
• Gene Name: KLHL34
• Organism: Homo sapiens (Human).
• Sequence Length: 644
• Protein Sequence: MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCALPWAWSGLRCAVLQLAEGGDDEREGEVGEALDLVLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYFLSYCK ------CCCHHHHHH	25.29	-
3	Phosphorylation	-----MSYFLSYCKA -----CCCHHHHHHH	13.77	-
6	Phosphorylation	--MSYFLSYCKAHGG --CCCHHHHHHHHCC	20.70	-
7	Phosphorylation	-MSYFLSYCKAHGGA -CCCHHHHHHHHCCC	10.50	-
237	Phosphorylation	ADVLRRVYSGSGLVL HHHHHHHHCCCCCEE	12.90	-
258	Phosphorylation	LIIQALNYHTTPSRQ HHHHHHHCCCCCCCC	11.03	-
280	Phosphorylation	TSIRSPQTRILLVGG CCCCCCCCEEEEECC	24.06	24719451
477	Phosphorylation	VGDRGVVYISGGKAG CCCCEEEEEECCCCC	6.22	21712546
479	Phosphorylation	DRGVVYISGGKAGRG CCEEEEEECCCCCCC	24.65	-
491	Phosphorylation	GRGEGGASSLRDLYV CCCCCCCCCHHHEEE	32.93	21712546
492	Phosphorylation	RGEGGASSLRDLYVL CCCCCCCCHHHEEEE	27.22	21712546
544	Phosphorylation	PFSEIERYDPGADQW CCCHHCCCCCCCCCC	17.44	-
552	Phosphorylation	DPGADQWTRLRPLPY CCCCCCCCCCCCCCC	17.75	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH34_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH34_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_HUMAN	HSPA8	physical	28514442
CHIP_HUMAN	STUB1	physical	28514442
BAG1_HUMAN	BAG1	physical	28514442
HSP72_HUMAN	HSPA2	physical	28514442
BAG3_HUMAN	BAG3	physical	28514442
STIP1_HUMAN	STIP1	physical	28514442
HSP76_HUMAN	HSPA6	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.