M3K15_HUMAN - dbPTM
M3K15_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID M3K15_HUMAN
UniProt AC Q6ZN16
Protein Name Mitogen-activated protein kinase kinase kinase 15
Gene Name MAP3K15
Organism Homo sapiens (Human).
Sequence Length 1313
Subcellular Localization
Protein Description May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis..
Protein Sequence MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68PhosphorylationLRAVYVRSESSQGGA
EEEEEEEECCCCCCC		31.6128450419
70PhosphorylationAVYVRSESSQGGAAG
EEEEEECCCCCCCCC		29.2528450419
71PhosphorylationVYVRSESSQGGAAGG
EEEEECCCCCCCCCC		28.8828450419
165PhosphorylationTDADTALSLKDMVTQ
CCHHHCCCHHHHHCC		30.8024719451
210UbiquitinationRRASEYMQPNWDNIL
HHHHHHCCCCHHHCC		27.5522817900
230PhosphorylationPLVDRFISLLKDIHV
HHHHHHHHHHHHCCC		25.5724719451
291PhosphorylationIIINLLLSYRDIQDY
HHHHHHHHCCCCCCH		20.3524626860
292PhosphorylationIINLLLSYRDIQDYD
HHHHHHHCCCCCCHH		16.5724626860
298PhosphorylationSYRDIQDYDAMVKLV
HCCCCCCHHHHHHHH		6.82-
333UbiquitinationYAFALNRRNSTGDRE
EEEEECCCCCCCCHH		40.1422817900
368PhosphorylationFCLCGRIYKDIFLDS
EEECCCHHCHHCCCC		10.9723403867
420PhosphorylationAGQQFETSLELRKIG
HCCCHHHHHHHHHHH		16.7924719451
432PhosphorylationKIGVRLNSLLGRKGS
HHHHHHHHHHCCCCC		29.5730257219
446PhosphorylationSLEKMNNYWDVGQFF
CHHHHCCCCCHHHHH		9.6622461510
484PhosphorylationPPVWYLRSLVQNLLL
CCHHHHHHHHHHHHH		30.2324114839
583PhosphorylationASSIKGISLSKFDER
HHHCCCCCHHHCCCC		34.9524719451
585PhosphorylationSIKGISLSKFDERCC
HCCCCCHHHCCCCEE		25.2018785766
608PhosphorylationDDFQIYFSTEEQCSR
CCEEEEEECHHHHHH		20.24-
609PhosphorylationDFQIYFSTEEQCSRF
CEEEEEECHHHHHHH		33.37-
630PhosphorylationMITNTAGSTVELEGE
HHHCCCCCEEEEECC		27.1524275569
681UbiquitinationNQVRIAIKEIPERDS
CCEEEEEECCCCCCC		40.3429967540
690PhosphorylationIPERDSRYSQPLHEE
CCCCCCCCCCCHHHH		18.6628851738
691PhosphorylationPERDSRYSQPLHEEI
CCCCCCCCCCHHHHH		24.9828851738
733PhosphorylationMEQVPGGSLSALLRS
EEECCCCCHHHHHHH		25.6822210691
735PhosphorylationQVPGGSLSALLRSKW
ECCCCCHHHHHHHCC		20.6822210691
751MethylationPMKEPTIKFYTKQIL
CCCCCCHHHHHHHHH		34.4923644510
763PhosphorylationQILEGLKYLHENQIV
HHHHHHHHHHHCCEE		20.52-
775UbiquitinationQIVHRDIKGDNVLVN
CEECCCCCCCCEEEE		65.5822817900
786UbiquitinationVLVNTYSGVVKISDF
EEEEEECCEEEEHHC		20.1622817900
797UbiquitinationISDFGTSKRLAGVNP
EHHCCCCCCCCCCCC		51.79-
808PhosphorylationGVNPCTETFTGTLQY
CCCCCCCHHCCCHHH		14.3519369195
812PhosphorylationCTETFTGTLQYMAPE
CCCHHCCCHHHHCHH		13.9711920685
878PhosphorylationPEIPEALSAEARAFI
CCCCHHHCHHHHHHH		30.9824719451
936PhosphorylationGVVLALPTQGEPMAT
EEEEEEECCCCCCCC		50.4826471730
943PhosphorylationTQGEPMATSSSEHGS
CCCCCCCCCCCCCCC		23.9226471730
944PhosphorylationQGEPMATSSSEHGSV
CCCCCCCCCCCCCCC		23.4826471730
945PhosphorylationGEPMATSSSEHGSVS
CCCCCCCCCCCCCCC		35.0826471730
946PhosphorylationEPMATSSSEHGSVSP
CCCCCCCCCCCCCCC		33.1226471730
950PhosphorylationTSSSEHGSVSPDSDA
CCCCCCCCCCCCCCC		22.7126471730
952PhosphorylationSSEHGSVSPDSDAQP
CCCCCCCCCCCCCCC		25.3726471730
955PhosphorylationHGSVSPDSDAQPDAL
CCCCCCCCCCCCCHH		37.9226471730
978PhosphorylationHHLGHLLSVPDESSA
HHHHHHCCCCCHHHH		37.6529449344
983PhosphorylationLLSVPDESSALEDRG
HCCCCCHHHHHHHCC		28.4329449344
984PhosphorylationLSVPDESSALEDRGL
CCCCCHHHHHHHCCC		34.5229449344
993PhosphorylationLEDRGLASSPEDRDQ
HHHCCCCCCCCHHHC		52.0123186163
994PhosphorylationEDRGLASSPEDRDQG
HHCCCCCCCCHHHCC		27.0521815630
1201PhosphorylationLVEKEREYQNLLRQT
HHHHHHHHHHHHHHH		14.66-
1269PhosphorylationVEEGYTLSDILNEIT
HHCCCCHHHHHHHHC		18.14-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of M3K15_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of M3K15_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of M3K15_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB10_HUMANRAB10physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of M3K15_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; THR-936 AND THR-943,AND MASS SPECTROMETRY.

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