ASB17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB17_HUMAN
• UniProt AC: Q8WXJ9
• Protein Name: Ankyrin repeat and SOCS box protein 17
• Gene Name: ASB17
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Protein Description: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MSKSTKLCGKTSCPRSNIFCNLLDKIVKRPSLQFLGQWGYHCYEPRIYRSLAKILRYVDLDGFDALLTDYIAFVEKSGYRFEVSFNLDFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSCNLALIWRTFTPVYCPSPLSGITPLFYVAQTRQSNIFKILLQYGILEREKNPINIVLTIVLYPSRVRVMVDRELADIHEDAKTCLVLCSRVLSVISVKEIKTQLSLGRHPIISNWFDYIPSTRYKDPCELLHLCRLTIRNQLLTNNMLPDGIFSLLIPARLQNYLNLEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
228	Phosphorylation	ISVKEIKTQLSLGRH HCHHHHHHHHHCCCC	40.16	28634298
231	Phosphorylation	KEIKTQLSLGRHPII HHHHHHHHCCCCCCH	20.96	28634298
239	Phosphorylation	LGRHPIISNWFDYIP CCCCCCHHHHHHCCC	28.82	28634298
244	Phosphorylation	IISNWFDYIPSTRYK CHHHHHHCCCCCCCC	12.78	28634298
247	Phosphorylation	NWFDYIPSTRYKDPC HHHHCCCCCCCCCHH	18.89	28634298
248	Phosphorylation	WFDYIPSTRYKDPCE HHHCCCCCCCCCHHH	32.44	28634298
270	Phosphorylation	TIRNQLLTNNMLPDG HHHHHHHHCCCCCCC	32.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASB17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASB17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSPB1_HUMAN	HSPB1	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
RCN2_HUMAN	RCN2	physical	24337577
EFTU_HUMAN	TUFM	physical	24337577
AT2A2_HUMAN	ATP2A2	physical	24337577
SSRD_HUMAN	SSR4	physical	24337577
ARF4_HUMAN	ARF4	physical	24337577
VAPA_HUMAN	VAPA	physical	24337577
CBPD_HUMAN	CPD	physical	24337577
RL23_HUMAN	RPL23	physical	24337577
TBB3_HUMAN	TUBB3	physical	24337577
RAB10_HUMAN	RAB10	physical	24337577
VDAC1_HUMAN	VDAC1	physical	24337577
PHB2_HUMAN	PHB2	physical	24337577
TBB5_HUMAN	TUBB	physical	24337577
TBB4B_HUMAN	TUBB4B	physical	24337577
TBB2B_HUMAN	TUBB2B	physical	24337577
TXTP_HUMAN	SLC25A1	physical	24337577
TBA1B_HUMAN	TUBA1B	physical	24337577

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.