dbPTM

GRK7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRK7_HUMAN
UniProt AC	Q8WTQ7
Protein Name	Rhodopsin kinase
Gene Name	GRK7
Organism	Homo sapiens (Human).
Sequence Length	553
Subcellular Localization	Membrane Lipid-anchor .
Protein Description	Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO)..
Protein Sequence	MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	YLQARKPSDCDSKEL HHHCCCCCCCCHHHH	54.64	22817900
36	Phosphorylation	ELQRRRRSLALPGLQ HHHHHHHHHHCCCHH	19.04	22817900
85	Phosphorylation	PTFRKAATFLEDVQN HHHHHHHHHHHHHHC	33.34	27251275
229	Acetylation	LDKKRLKKKGGEKMA CCHHHHHHCCCHHHH	62.33	130811
230	Acetylation	DKKRLKKKGGEKMAL CHHHHHHCCCHHHHH	71.24	130813
234	Acetylation	LKKKGGEKMALLEKE HHHCCCHHHHHHHHH	32.52	130815
433	Acetylation	ICRLFLAKKPEQRLG HHHHHHCCCHHHCCC	71.64	7308127
490	Phosphorylation	IAEIDDFSEVRGVEF HHHCCCCHHCCCCCC	42.02	24719451
550	Methylation	NSSKSGVCLLL---- CCCCCCEEEEC----	2.24	-
550	Geranylgeranylation	NSSKSGVCLLL---- CCCCCCEEEEC----	2.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
23	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
23	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
23	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
36	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
36	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
36	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
36	S	Phosphorylation	Kinase	PKA	-	Uniprot
36	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
36	S	Phosphorylation	15946941
Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
490	S	Phosphorylation	18803695
Autophosphorylated in vitro at Ser-490.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRK7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GRK7_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRK7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation of GRK7 by PKA in cone photoreceptor cells isregulated by light."; Osawa S., Jo R., Weiss E.R.; J. Neurochem. 107:1314-1324(2008). Cited for: TISSUE SPECIFICITY, AND PHOSPHORYLATION AT SER-36.	18803695 [Abstract]