M3K6_HUMAN - dbPTM
M3K6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID M3K6_HUMAN
UniProt AC O95382
Protein Name Mitogen-activated protein kinase kinase kinase 6
Gene Name MAP3K6
Organism Homo sapiens (Human).
Sequence Length 1288
Subcellular Localization
Protein Description Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways..
Protein Sequence MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationSGAERAGSCWQDPLA
CCCCCCCCCCCCHHH		15.9328857561
65PhosphorylationGLEPREGTEAEPLPL
CCCCCCCCCCCCCCH		27.5428857561
121UbiquitinationDVVVLEVSSSLVQPS
CEEEEEECHHHCCHH		12.5822817900
209PhosphorylationLVQAGVGTEALLTPL
HHHCCCCHHHHHHHH		18.7128857561
229PhosphorylationRLLEATPTDSCGYFR
HHHHCCCCCCCHHHH		35.8728857561
231PhosphorylationLEATPTDSCGYFRET
HHCCCCCCCHHHHHH		16.3628857561
251PhosphorylationRQARERFSGPQLRQE
HHHHHHHCHHHHHHH		56.6424719451
263 (in isoform 2)Ubiquitination-23.9321906983
354UbiquitinationSVAPDLYCMCGRIYK
CCCCCHHHHHCHHHH		2.0622817900
367PhosphorylationYKDMFFSSGFQDAGH
HHHHHCCCCCCCCCC		38.17-
491UbiquitinationYQHFRPTPEPPGGPP
HHHCCCCCCCCCCCC		55.5722817900
496 (in isoform 2)Ubiquitination-34.5121906983
532 (in isoform 3)Ubiquitination-5.2721906983
532UbiquitinationCLVLVLEMNKVLLPA
EEEEEEECCCCEEEE		5.2722817900
540UbiquitinationNKVLLPAKLEVRGTD
CCCEEEEEEEECCCC		43.1521906983
540 (in isoform 1)Ubiquitination-43.1521906983
580UbiquitinationASICGVSASKRDERC
HHHCCCCCCCCCCCE		19.3722817900
605UbiquitinationDVQLCFPSVGHCQWF
HEEECCCCCCHHHHH		22.0721963094
633 (in isoform 2)Ubiquitination-53.5121906983
677UbiquitinationTRVRIAIKEIPERDS
EEEEEEEECCCCCCC		40.34-
717PhosphorylationGSASQGGYLKIFMEE
CCCCCCCEEEEEEEE		16.20-
722 (in isoform 2)Ubiquitination-4.9721906983
731PhosphorylationEVPGGSLSSLLRSVW
ECCCCCHHHHHHHHH		22.1924945436
732PhosphorylationVPGGSLSSLLRSVWG
CCCCCHHHHHHHHHC		36.3924719451
765UbiquitinationGLGYLHDNHIVHRDI
HHCCCCCCCEECCCC		18.9422817900
765 (in isoform 3)Ubiquitination-18.9421906983
773UbiquitinationHIVHRDIKGDNVLIN
CEECCCCCCCCEEEE		65.5821906983
773 (in isoform 1)Ubiquitination-65.5821906983
789PhosphorylationFSGLLKISDFGTSKR
CCCEEEHHHCCCCCC		25.87-
793PhosphorylationLKISDFGTSKRLAGI
EEHHHCCCCCCCCCC		30.94-
795UbiquitinationISDFGTSKRLAGITP
HHHCCCCCCCCCCCC		51.79-
801PhosphorylationSKRLAGITPCTETFT
CCCCCCCCCCCCCCC		16.05-
804PhosphorylationLAGITPCTETFTGTL
CCCCCCCCCCCCCCH		38.9819369195
806PhosphorylationGITPCTETFTGTLQY
CCCCCCCCCCCCHHH		14.3517210579
810PhosphorylationCTETFTGTLQYMAPE
CCCCCCCCHHHHCHH		13.9711920685
896PhosphorylationPDPRLRASAQTLLGD
CCHHHHHHHHHHHCC		17.93-
899PhosphorylationRLRASAQTLLGDPFL
HHHHHHHHHHCCCCC		24.54-
902UbiquitinationASAQTLLGDPFLQPG
HHHHHHHCCCCCCCC		43.5922817900
902 (in isoform 3)Ubiquitination-43.5921906983
910 (in isoform 1)Ubiquitination-54.6121906983
910UbiquitinationDPFLQPGKRSRSPSS
CCCCCCCCCCCCCCC		54.6121906983
912PhosphorylationFLQPGKRSRSPSSPR
CCCCCCCCCCCCCCC		40.3618691976
914PhosphorylationQPGKRSRSPSSPRHA
CCCCCCCCCCCCCCC		30.3118691976
916PhosphorylationGKRSRSPSSPRHAPR
CCCCCCCCCCCCCCC		54.9726699800
917PhosphorylationKRSRSPSSPRHAPRP
CCCCCCCCCCCCCCC		29.3626699800
925PhosphorylationPRHAPRPSDAPSASP
CCCCCCCCCCCCCCC		47.9223927012
929PhosphorylationPRPSDAPSASPTPSA
CCCCCCCCCCCCCCC		43.0023927012
931PhosphorylationPSDAPSASPTPSANS
CCCCCCCCCCCCCCC		33.3723927012
933PhosphorylationDAPSASPTPSANSTT
CCCCCCCCCCCCCCC		27.6423927012
935PhosphorylationPSASPTPSANSTTQS
CCCCCCCCCCCCCCC		42.4327251275
938PhosphorylationSPTPSANSTTQSQTF
CCCCCCCCCCCCCEE		32.3323927012
939PhosphorylationPTPSANSTTQSQTFP
CCCCCCCCCCCCEEC		28.7623927012
940PhosphorylationTPSANSTTQSQTFPC
CCCCCCCCCCCEECC		26.5023927012
942PhosphorylationSANSTTQSQTFPCPQ
CCCCCCCCCEECCCC		29.1523927012
944PhosphorylationNSTTQSQTFPCPQAP
CCCCCCCEECCCCCC		34.4923927012
952PhosphorylationFPCPQAPSQHPPSPP
ECCCCCCCCCCCCCC		44.1023927012
957PhosphorylationAPSQHPPSPPKRCLS
CCCCCCCCCCCCCCC		59.2829507054
964PhosphorylationSPPKRCLSYGGTSQL
CCCCCCCCCCCCCCC		25.9225159151
965PhosphorylationPPKRCLSYGGTSQLR
CCCCCCCCCCCCCCC		13.4623186163
984PhosphorylationPAAEEPASPEESSGL
CCCCCCCCHHHCCCH		43.4929255136
988PhosphorylationEPASPEESSGLSLLH
CCCCHHHCCCHHHHC		28.2223663014
989PhosphorylationPASPEESSGLSLLHQ
CCCHHHCCCHHHHCH		47.2123663014
991 (in isoform 3)Ubiquitination-3.3521906983
991UbiquitinationSPEESSGLSLLHQES
CHHHCCCHHHHCHHH		3.3522817900
992PhosphorylationPEESSGLSLLHQESK
HHHCCCHHHHCHHHH		32.2023663014
998PhosphorylationLSLLHQESKRRAMLA
HHHHCHHHHHHHHHH		25.5427251275
999 (in isoform 1)Ubiquitination-45.1921906983
999UbiquitinationSLLHQESKRRAMLAA
HHHCHHHHHHHHHHH		45.1922817900
1016UbiquitinationEQELPALAENLHQEQ
HHHHHHHHHHHHHHH		13.0221963094
1024UbiquitinationENLHQEQKQEQGARL
HHHHHHHHHHHHHHH		55.8621963094
1106PhosphorylationHWMFVLDSLLSRAVR
HHHHHHHHHHHHHHH		27.3524719451
1109PhosphorylationFVLDSLLSRAVRAAL
HHHHHHHHHHHHHHH		24.4024719451
1129PhosphorylationEVEKEAVSPRSEELS
HHHHHCCCCCHHHHC		22.9528355574
1132PhosphorylationKEAVSPRSEELSNEG
HHCCCCCHHHHCCCC		38.5128270605
1136PhosphorylationSPRSEELSNEGDSQQ
CCCHHHHCCCCCCCC		35.7928270605
1141PhosphorylationELSNEGDSQQSPGQQ
HHCCCCCCCCCCCCC		40.7628270605
1144PhosphorylationNEGDSQQSPGQQSPL
CCCCCCCCCCCCCCC		24.3028857561
1149PhosphorylationQQSPGQQSPLPVEPE
CCCCCCCCCCCCCCC		22.1026657352
1187PhosphorylationLAGKEREYQALVQRA
HCCCHHHHHHHHHHH		12.8130576142
1281PhosphorylationILAQRAGSTPVTSGP
HHHHHCCCCCCCCCC		28.6624719451
1282PhosphorylationLAQRAGSTPVTSGP-
HHHHCCCCCCCCCC-		22.3624719451
1286O-linked_GlycosylationAGSTPVTSGP-----
CCCCCCCCCC-----		49.6722564745
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
806TPhosphorylationKinaseMAP3K6O95382
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of M3K6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of M3K6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
M3K5_HUMANMAP3K5physical
9875215
FKBP5_HUMANFKBP5physical
28514442
UBP4_HUMANUSP4physical
28514442
LIMD1_HUMANLIMD1physical
28514442
PCDA4_HUMANPCDHA4physical
28514442
RN123_HUMANRNF123physical
28514442
UBAC1_HUMANUBAC1physical
28514442
ASPM_HUMANASPMphysical
28514442
ERGI2_HUMANERGIC2physical
28514442
CDC37_HUMANCDC37physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of M3K6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-804; THR-806; SER-964;SER-984; SER-1129 AND SER-1149, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984, AND MASSSPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984 AND SER-1129, ANDMASS SPECTROMETRY.

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