| UniProt ID | PCDA4_HUMAN | |
|---|---|---|
| UniProt AC | Q9UN74 | |
| Protein Name | Protocadherin alpha-4 {ECO:0000305} | |
| Gene Name | PCDHA4 {ECO:0000312|HGNC:HGNC:8670} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 947 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Detected in dendrites and synapses. |
|
| Protein Description | Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.. | |
| Protein Sequence | MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSRDREDQLQTTEESFAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 139 | N-linked_Glycosylation | VFPATQKNLSIAESR CCCCCCCCCCHHHCC | 29.24 | UniProtKB CARBOHYD | |
| 257 | N-linked_Glycosylation | RLLENVPNGTLVIKL EEEECCCCCEEEEEE | 52.37 | UniProtKB CARBOHYD | |
| 259 | Phosphorylation | LENVPNGTLVIKLNA EECCCCCEEEEEECH | 25.21 | 23403867 | |
| 265 | N-linked_Glycosylation | GTLVIKLNASDLDEG CEEEEEECHHHCCCC | 32.18 | UniProtKB CARBOHYD | |
| 356 | Phosphorylation | DLEFKSLSLPIREDA CCEEEECCCCCCCCC | 38.91 | 24719451 | |
| 432 | Phosphorylation | VTARDGGSPSLWATA EEECCCCCCCCEEEE | 19.49 | - | |
| 506 | Phosphorylation | VGERALSSYVSVHAE HHHHHHHHEEEEEEC | 30.33 | - | |
| 514 | Phosphorylation | YVSVHAESGKVYALQ EEEEEECCCCEEEEC | 44.70 | 29759185 | |
| 548 | N-linked_Glycosylation | GVPPLGSNVTLQVFV CCCCCCCCEEEEEEE | 29.06 | UniProtKB CARBOHYD | |
| 601 | Phosphorylation | VRAVDADSGYNAWLS EEEEECCCCCCEEEE | 44.92 | 18187866 | |
| 603 | Phosphorylation | AVDADSGYNAWLSYE EEECCCCCCEEEEEE | 12.98 | 22817900 | |
| 660 | Phosphorylation | DHGEPALTATATVLV CCCCCCCEEEEEEHH | 24.86 | - | |
| 662 | Phosphorylation | GEPALTATATVLVSL CCCCCEEEEEEHHHH | 20.02 | - | |
| 664 | Phosphorylation | PALTATATVLVSLVE CCCEEEEEEHHHHHH | 15.26 | - | |
| 679 | Phosphorylation | SGQAPKASSRALVGA CCCCCCHHCCCEECC | 26.87 | - | |
| 680 | Phosphorylation | GQAPKASSRALVGAV CCCCCHHCCCEECCC | 26.82 | - | |
| 738 | Phosphorylation | ACAPGKPTLVCSSAV CCCCCCCEEEEECCC | 35.00 | - | |
| 743 | Phosphorylation | KPTLVCSSAVGSWSY CCEEEEECCCCCCCC | 23.11 | 22468782 | |
| 747 | Phosphorylation | VCSSAVGSWSYSQQR EEECCCCCCCCCCCC | 13.27 | 22210691 | |
| 749 | Phosphorylation | SSAVGSWSYSQQRRP ECCCCCCCCCCCCCC | 19.32 | 22210691 | |
| 750 | Phosphorylation | SAVGSWSYSQQRRPR CCCCCCCCCCCCCCC | 12.30 | 20068231 | |
| 751 | Phosphorylation | AVGSWSYSQQRRPRV CCCCCCCCCCCCCCC | 17.83 | 28857561 | |
| 760 | Phosphorylation | QRRPRVCSGEGPPKT CCCCCCCCCCCCCCC | 36.70 | 28348404 | |
| 767 | Phosphorylation | SGEGPPKTDLMAFSP CCCCCCCCCCEEECC | 39.89 | - | |
| 773 | Phosphorylation | KTDLMAFSPSLPDSR CCCCEEECCCCCCCC | 12.21 | 20068231 | |
| 775 | Phosphorylation | DLMAFSPSLPDSRDR CCEEECCCCCCCCCH | 51.87 | 20068231 | |
| 779 | Phosphorylation | FSPSLPDSRDREDQL ECCCCCCCCCHHHHH | 33.85 | 20068231 | |
| 805 | Phosphorylation | QPNPDWRYSASLRAG CCCCCCCCEEHHHCC | 12.34 | - | |
| 806 | Phosphorylation | PNPDWRYSASLRAGM CCCCCCCEEHHHCCC | 11.65 | 24719451 | |
| 808 | Phosphorylation | PDWRYSASLRAGMHS CCCCCEEHHHCCCCC | 16.67 | 24719451 | |
| 815 | Phosphorylation | SLRAGMHSSVHLEEA HHHCCCCCCEEHHHC | 25.76 | 28857561 | |
| 816 | Phosphorylation | LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC | 10.01 | 24719451 | |
| 890 | Phosphorylation | DKFIIPGSPAIISIR CCEEECCCCEEEEEE | 13.05 | 27050516 | |
| 895 | Phosphorylation | PGSPAIISIRQEPTN CCCCEEEEEECCCCC | 12.95 | 27732954 | |
| 901 | Phosphorylation | ISIRQEPTNSQIDKS EEEECCCCCCCCCHH | 46.91 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCDA4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCDA4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCDA4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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