PCDAC_HUMAN - dbPTM
PCDAC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDAC_HUMAN
UniProt AC Q9UN75
Protein Name Protocadherin alpha-12
Gene Name PCDHA12
Organism Homo sapiens (Human).
Sequence Length 941
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLIIAICAVSSLLVLTLLLYTALRCSAPPTVSRCAPGKPTLVCSSAVGSWSYSQQRRQRVCSAESPPKTDLMAFSPSLQLSREDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationIGPRGPGSQRLLLSL
ECCCCCHHHHHHHHH		18.4324719451
257N-linked_GlycosylationVLSENVQNDTRVIQL
EEEECCCCCEEEEEC		48.62UniProtKB CARBOHYD
265N-linked_GlycosylationDTRVIQLNASDPDEG
CEEEEECCCCCCCCC		22.48UniProtKB CARBOHYD
390PhosphorylationGQVICSLTPHVPFKL
CEEEEECCCCCCEEE		8.61-
432PhosphorylationVTARDGGSPSLWATA
EEEECCCCCCCEEEE		19.49-
506PhosphorylationVGEHALSSYVSVHAE
HCHHHHHCEEEEEEC		30.33-
514PhosphorylationYVSVHAESGKVYALQ
EEEEEECCCCEEEEC		44.70-
548N-linked_GlycosylationGVPPLGSNVTLQVFV
CCCCCCCCEEEEEEE		29.06UniProtKB CARBOHYD
601PhosphorylationVRAVDADSGYNAWLS
EEEEECCCCCCEEEE		44.9218187866
603PhosphorylationAVDADSGYNAWLSYE
EEECCCCCCEEEEEE		12.9822817900
738PhosphorylationRCAPGKPTLVCSSAV
CCCCCCCEEEEECCC		35.00-
743PhosphorylationKPTLVCSSAVGSWSY
CCEEEEECCCCCCCH		23.1122468782
747PhosphorylationVCSSAVGSWSYSQQR
EEECCCCCCCHHHHH		13.2722210691
749PhosphorylationSSAVGSWSYSQQRRQ
ECCCCCCCHHHHHHH		19.3222210691
750PhosphorylationSAVGSWSYSQQRRQR
CCCCCCCHHHHHHHH		12.3028857561
751PhosphorylationAVGSWSYSQQRRQRV
CCCCCCHHHHHHHHH		17.8328857561
763PhosphorylationQRVCSAESPPKTDLM
HHHCCCCCCCCCCCC		46.3422468782
779PhosphorylationFSPSLQLSREDCLNP
ECCCCCCCHHHHCCC		22.2122468782
799PhosphorylationQPNPDWRYSASLRAG
CCCCCCCCCCHHHCC		12.3420736484
800PhosphorylationPNPDWRYSASLRAGM
CCCCCCCCCHHHCCC		11.6524719451
802PhosphorylationPDWRYSASLRAGMHS
CCCCCCCHHHCCCCC		16.6724719451
809PhosphorylationSLRAGMHSSVHLEEA
HHHCCCCCCEEHHHC		25.7628857561
810PhosphorylationLRAGMHSSVHLEEAG
HHCCCCCCEEHHHCC		10.0124719451
868UbiquitinationKYGPGNPKQSGPGEL
ECCCCCCCCCCCCCC		62.1833845483
884PhosphorylationDKFIIPGSPAIISIR
CCEEECCCCEEEEEE		13.0527050516
889PhosphorylationPGSPAIISIRQEPTN
CCCCEEEEEECCCCC		12.9527732954
895PhosphorylationISIRQEPTNSQIDKS
EEEECCCCCCCCCHH		46.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDAC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDAC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDAC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCDAB_HUMANPCDHA11physical
28514442
LONP2_HUMANLONP2physical
28514442
Z518A_HUMANZNF518Aphysical
28514442
AGAP1_HUMANAGAP1physical
28514442
DCMC_HUMANMLYCDphysical
28514442
KLRG2_HUMANKLRG2physical
28514442
CP2S1_HUMANCYP2S1physical
28514442
C2C2L_HUMANC2CD2Lphysical
28514442
FRMD5_HUMANFRMD5physical
28514442
MXRA7_HUMANMXRA7physical
28514442
IL1AP_HUMANIL1RAPphysical
28514442
DYR2_HUMANDHFRL1physical
28514442
RL23_HUMANRPL23physical
28514442
CNNM1_HUMANCNNM1physical
28514442
TIM16_HUMANPAM16physical
28514442
CENPN_HUMANCENPNphysical
28514442
TM192_HUMANTMEM192physical
28514442
E2AK3_HUMANEIF2AK3physical
28514442
NEK4_HUMANNEK4physical
28514442
AGRL1_HUMANLPHN1physical
28514442
ACD10_HUMANACAD10physical
28514442
EPHB4_HUMANEPHB4physical
28514442
TCAL2_HUMANTCEAL2physical
28514442
INT4_HUMANINTS4physical
28514442
LTBP1_HUMANLTBP1physical
28514442
PPOX_HUMANPPOXphysical
28514442
INT5_HUMANINTS5physical
28514442
ABCB6_HUMANABCB6physical
28514442
AT2A3_HUMANATP2A3physical
28514442
F162A_HUMANFAM162Aphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDAC_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory