ABCB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCB6_HUMAN
• UniProt AC: Q9NP58
• Protein Name: ATP-binding cassette sub-family B member 6, mitochondrial
• Gene Name: ABCB6
• Organism: Homo sapiens (Human).
• Sequence Length: 842
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pa
• Protein Description: Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis..
• Protein Sequence: MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	S-palmitoylation	ALVLALPCRRRERPA HHHHHCCCCCCCCCC	5.71	29575903
61	Phosphorylation	ERPAGADSLSWGAGP CCCCCCCCCCCCCCC	24.62	28857561
63	Phosphorylation	PAGADSLSWGAGPRI CCCCCCCCCCCCCCC	27.67	30108239
167	Phosphorylation	AENLALVSWNSPQWW HHHCCCCCCCCCCCE	22.76	27732954
170	Phosphorylation	LALVSWNSPQWWWAR CCCCCCCCCCCEEEE	16.53	27732954
357	Phosphorylation	FSHLHELSLRWHLGR HHCHHHHHHHHHHCC	16.95	24719451
366	Phosphorylation	RWHLGRRTGEVLRIA HHHHCCCCCCEEEEE	36.01	24702127
418 (in isoform 4)	Ubiquitination	-	3.26	21890473
418	Ubiquitination	AWFGLIVFLCMSLYL HHHHHHHHHHHHHHH	3.26	29901268
436 (in isoform 4)	Ubiquitination	-	35.29	21890473
436	Ubiquitination	IVVTEWRTKFRRAMN HHHHHHHHHHHHHHH	35.29	33845483
444	Phosphorylation	KFRRAMNTQENATRA HHHHHHHHHHHHHHH	24.95	15979861
449	Phosphorylation	MNTQENATRARAVDS HHHHHHHHHHHHHHH	36.12	15979853
456	Phosphorylation	TRARAVDSLLNFETV HHHHHHHHHHCCEEE	28.32	25850435
464 (in isoform 1)	Ubiquitination	-	49.81	21890473
464	Ubiquitination	LLNFETVKYYNAESY HHCCEEEEEECCCCC	49.81	21906983
482 (in isoform 1)	Ubiquitination	-	25.96	21890473
482	Sumoylation	RYREAIIKYQGLEWK HHHHHHHHHCCCCCC	25.96	-
482	Ubiquitination	RYREAIIKYQGLEWK HHHHHHHHHCCCCCC	25.96	21963094
483	Phosphorylation	YREAIIKYQGLEWKS HHHHHHHHCCCCCCC	9.45	28348404
490	Phosphorylation	YQGLEWKSSASLVLL HCCCCCCCCEEEEEE	32.01	28348404
491	Phosphorylation	QGLEWKSSASLVLLN CCCCCCCCEEEEEEC	20.39	28348404
493	Phosphorylation	LEWKSSASLVLLNQT CCCCCCEEEEEECCC	22.43	28348404
500	Phosphorylation	SLVLLNQTQNLVIGL EEEEECCCCCHHHHH	20.53	27251275
513	Phosphorylation	GLGLLAGSLLCAYFV HHHHHHHHHHHHHHH	16.74	28348404
518	Phosphorylation	AGSLLCAYFVTEQKL HHHHHHHHHHCCCCC	9.51	28348404
521	Phosphorylation	LLCAYFVTEQKLQVG HHHHHHHCCCCCCCC	23.85	28348404
529	Ubiquitination	EQKLQVGDYVLFGTY CCCCCCCCEEEEEEE	31.35	33845483
569	Ubiquitination	ENMFDLLKEETEVKD HHHHHHHHHCCCCCC	61.88	-
575	Ubiquitination	LKEETEVKDLPGAGP HHHCCCCCCCCCCCC	47.52	33845483
605	Phosphorylation	SYADGRETLQDVSFT EECCCCCEECEEEEE	28.49	20068231
610	Phosphorylation	RETLQDVSFTVMPGQ CCEECEEEEEECCCC	24.40	20068231
612	Phosphorylation	TLQDVSFTVMPGQTL EECEEEEEECCCCEE	14.37	20068231
618	Phosphorylation	FTVMPGQTLALVGPS EEECCCCEEEEECCC	21.66	20068231
625	Phosphorylation	TLALVGPSGAGKSTI EEEEECCCCCCHHHH	35.03	20068231
680	Ubiquitination	TVLFNDTIADNIRYG EEEECCCCCCCCEEC	5.17	33845483
697 (in isoform 4)	Ubiquitination	-	30.46	21890473
725	Ubiquitination	TQVGERGLKLSGGEK CCCCCCCEECCCCHH	6.72	29901268
726	Ubiquitination	QVGERGLKLSGGEKQ CCCCCCEECCCCHHH	43.35	27667366
743	Ubiquitination	AIARTILKAPGIILL HHHHHHHHCCCEEEE	49.00	2190698
743 (in isoform 1)	Ubiquitination	-	49.00	21890473
754	Phosphorylation	IILLDEATSALDTSN EEEEECCCCCCCCCC	16.69	30108239
755	Phosphorylation	ILLDEATSALDTSNE EEEECCCCCCCCCCH	33.60	23025827
759	Phosphorylation	EATSALDTSNERAIQ CCCCCCCCCCHHHHH	34.01	30108239
760	Phosphorylation	ATSALDTSNERAIQA CCCCCCCCCHHHHHH	36.04	30108239
771	Ubiquitination	AIQASLAKVCANRTT HHHHHHHHHHCCCCE	43.04	29901268
786	Phosphorylation	IVVAHRLSTVVNADQ EEEEECHHHCCCCCE	21.07	22468782
790 (in isoform 4)	Ubiquitination	-	33.20	-
790	Ubiquitination	HRLSTVVNADQILVI ECHHHCCCCCEEEEE	33.20	33845483
836	Ubiquitination	EETSEDTKPQTMER- CCCCCCCCCCCCCC-	47.66	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM40_HUMAN	TOMM40	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614497: Microphthalmia, isolated, with coloboma, 7 (MCOPCB7)
• 615402: Dyschromatosis universalis hereditaria 3 (DUH3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.