PCDAB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDAB_HUMAN
• UniProt AC: Q9Y5I1
• Protein Name: Protocadherin alpha-11
• Gene Name: PCDHA11
• Organism: Homo sapiens (Human).
• Sequence Length: 949
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGLNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	FQRRGLGTPRLQLWL CCCCCCCCHHHHHHH	15.41	26270265
265	N-linked_Glycosylation	ETLVLKLNATDRDEG CEEEEEECCCCCCCC	38.93	UniProtKB CARBOHYD
304	N-linked_Glycosylation	NNGEVRVNGTLDYEE CCCEEEEEEEEECCC	27.45	UniProtKB CARBOHYD
322	Phosphorylation	YKIEVQATDKGTPPM EEEEEEEECCCCCCC	22.58	22985185
355	Phosphorylation	EVAVTSLSLPVREDA CEEEEEEEECCCCCC	30.32	24945436
431	Phosphorylation	VTARDGGSPSLWATA EEECCCCCCCCEEEE	19.49	-
505	Phosphorylation	LGDRALSSYVSVHAE HHHHHHHCEEEEEEC	30.33	-
513	Phosphorylation	YVSVHAESGKVYALQ EEEEEECCCCEEEEC	44.70	29759185
547	N-linked_Glycosylation	GVPPLSSNVTLQVFV CCCCCCCCEEEEEEE	27.67	UniProtKB CARBOHYD
600	Phosphorylation	VRAVDADSGYNAWLS EEEEECCCCCCEEEE	44.92	18187866
602	Phosphorylation	AVDADSGYNAWLSYE EEECCCCCCEEEEEE	12.98	22817900
659	Phosphorylation	DHGEPALTATATVLV CCCCCCCEEEEEEHH	24.86	-
661	Phosphorylation	GEPALTATATVLVSL CCCCCEEEEEEHHHH	20.02	-
663	Phosphorylation	PALTATATVLVSLVE CCCEEEEEEHHHHHH	15.26	-
678	Phosphorylation	SGQAPKASSRTLAGA CCCCCCCCCCCCCCC	26.86	-
679	Phosphorylation	GQAPKASSRTLAGAA CCCCCCCCCCCCCCC	33.86	-
746	Phosphorylation	VCSRAVGSWSYSQQR EEECCCCCCCHHHHH	13.27	28857561
749	Phosphorylation	RAVGSWSYSQQRRQR CCCCCCCHHHHHHHH	12.30	28857561
750	Phosphorylation	AVGSWSYSQQRRQRV CCCCCCHHHHHHHHH	17.83	28857561
807	Phosphorylation	QPNPDWRYSASLRAG CCCCCCCCEEEHHCC	12.34	-
808	Phosphorylation	PNPDWRYSASLRAGM CCCCCCCEEEHHCCC	11.65	24719451
810	Phosphorylation	PDWRYSASLRAGMHS CCCCCEEEHHCCCCC	16.67	24719451
817	Phosphorylation	SLRAGMHSSVHLEEA EHHCCCCCCEEHHHC	25.76	28857561
818	Phosphorylation	LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC	10.01	24719451
876	Ubiquitination	KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC	62.18	33845483
892	Phosphorylation	DKFIIPGSPAIISIR CCEEECCCCEEEEEE	13.05	27050516
897	Phosphorylation	PGSPAIISIRQEPTN CCCCEEEEEECCCCC	12.95	27732954
903	Phosphorylation	ISIRQEPTNSQIDKS EEEECCCCCCCCCHH	46.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDAB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDAB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDAB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDAB_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.