PCDA7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDA7_HUMAN
• UniProt AC: Q9UN72
• Protein Name: Protocadherin alpha-7 {ECO:0000305}
• Gene Name: PCDHA7 {ECO:0000312|HGNC:HGNC:8673}
• Organism: Homo sapiens (Human).
• Sequence Length: 937
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MVCPNGYDPGGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCKFRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAGPETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSEGACSLVKPTLVCSSAVGSWSFSQQRRQRVCSGEGPPKTDLMAFSPSLPQGPSSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
245	Phosphorylation	NAPVFDRTLYTVKLP CCCCCEEEEEEEECC	26.43	22210691
250	Acetylation	DRTLYTVKLPENVSI EEEEEEEECCCCEEE	50.99	30591159
254	N-linked_Glycosylation	YTVKLPENVSIGTLV EEEECCCCEEEEEEE	30.78	UniProtKB CARBOHYD
265	N-linked_Glycosylation	GTLVIHPNASDLDEG EEEEECCCHHHCCCC	37.60	UniProtKB CARBOHYD
267	Phosphorylation	LVIHPNASDLDEGLN EEECCCHHHCCCCCC	45.40	22210691
283	Phosphorylation	DIIYSFSSDVSPDIK CEEEEECCCCCCCHH	39.77	22210691
299	Phosphorylation	KFHMDPLSGAITVIG HCCCCCCCCCEEEEE	31.41	28787133
303	Phosphorylation	DPLSGAITVIGHMDF CCCCCCEEEEECCCH	12.92	23607784
313	Phosphorylation	GHMDFEESRAHKIPV ECCCHHHHHCCCCCH	27.80	24850871
432	Phosphorylation	VTARDGGSPSLWATA EEECCCCCCCEEEEE	19.49	-
506	Phosphorylation	VGERALSSYVSVHAE CCCHHHHHEEEEEEC	30.33	-
514	Phosphorylation	YVSVHAESGKVYALQ EEEEEECCCCEEEEC	44.70	29759185
548	N-linked_Glycosylation	GVPPLGSNVTLQVFV CCCCCCCCEEEEEEE	29.06	UniProtKB CARBOHYD
601	Phosphorylation	VRAVDADSGYNAWLS EEEEECCCCCCEEEE	44.92	18187866
603	Phosphorylation	AVDADSGYNAWLSYE EEECCCCCCEEEEEE	12.98	22817900
609	Phosphorylation	GYNAWLSYELQPVAA CCCEEEEEECCCCCC	20.63	22817900
679	Phosphorylation	SGQAPKASSRASLGI CCCCCCCCCCCCCCC	26.87	-
680	Phosphorylation	GQAPKASSRASLGIA CCCCCCCCCCCCCCC	36.40	-
760 (in isoform 2)	Phosphorylation	-	36.70	22798277
760	Phosphorylation	QRRQRVCSGEGPPKT HHHHHHHCCCCCCCC	36.70	28348404
767	Phosphorylation	SGEGPPKTDLMAFSP CCCCCCCCCEEEECC	39.89	-
773 (in isoform 2)	Phosphorylation	-	12.21	22798277
773	Phosphorylation	KTDLMAFSPSLPQGP CCCEEEECCCCCCCC	12.21	-
775 (in isoform 2)	Phosphorylation	-	52.03	22798277
795	Phosphorylation	QPNPDWRYSASLRAG CCCCCCCCEEHHHCC	12.34	-
796	Phosphorylation	PNPDWRYSASLRAGM CCCCCCCEEHHHCCC	11.65	24719451
798	Phosphorylation	PDWRYSASLRAGMHS CCCCCEEHHHCCCCC	16.67	24719451
805	Phosphorylation	SLRAGMHSSVHLEEA HHHCCCCCCEEHHHC	25.76	28857561
806	Phosphorylation	LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC	10.01	24719451
864	Ubiquitination	KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC	62.18	33845483
880	Phosphorylation	DKFIIPGSPAIISIR CCEEECCCCEEEEEE	13.05	27050516
885	Phosphorylation	PGSPAIISIRQEPTN CCCCEEEEEECCCCC	12.95	27732954
891	Phosphorylation	ISIRQEPTNSQIDKS EEEECCCCCCCCCHH	46.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDA7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDA7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDA7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.