PCDA1_HUMAN - dbPTM
PCDA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDA1_HUMAN
UniProt AC Q9Y5I3
Protein Name Protocadherin alpha-1
Gene Name PCDHA1
Organism Homo sapiens (Human).
Sequence Length 950
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Secreted .
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQRRQRVCSSEGPPKTDLMAFSPGLSPSLNTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
257N-linked_GlycosylationHLLETTANGTLVTTL
EEEEEECCCEEEEEE		41.72UniProtKB CARBOHYD
265N-linked_GlycosylationGTLVTTLNASDADEG
CEEEEEEEHHHCCCC		34.99UniProtKB CARBOHYD
286PhosphorylationFSFDSGISRDIQEKF
EEECCCCCHHHHHHH		27.6822468782
298PhosphorylationEKFKVDSSSGEIRLI
HHHCCCCCCCEEEEE		37.5922468782
299PhosphorylationKFKVDSSSGEIRLID
HHCCCCCCCEEEEEE		44.3822468782
310PhosphorylationRLIDKLDYEETKSYE
EEEEECCCCCCCCEE		26.5429759185
313PhosphorylationDKLDYEETKSYEIQV
EECCCCCCCCEEEEE		17.2229759185
327PhosphorylationVKAVDKGSPPMSNHC
EEEECCCCCCCCCCC		31.4128348404
331PhosphorylationDKGSPPMSNHCKVLV
CCCCCCCCCCCEEEE		29.2428348404
367PhosphorylationREDAPLSTVIALITV
CCCCCHHEEEEEEEE		24.5025690035
373PhosphorylationSTVIALITVSDRDSG
HEEEEEEEECCCCCC		18.1425690035
419PhosphorylationALDRESLSVYELVVT
CCCHHHCCEEEEEEE		31.75-
432PhosphorylationVTARDGGSPSLWATA
EEECCCCCCCCEEEE		19.49-
514PhosphorylationYVSVHAESGKVYALQ
CEEEEECCCCEEEEC		44.70-
548N-linked_GlycosylationGVPPLGSNVTLQVFV
CCCCCCCCEEEEEEE		29.06UniProtKB CARBOHYD
601PhosphorylationVRAVDADSGYNAWLS
EEEEECCCCCCEEEE		44.9218187866
603PhosphorylationAVDADSGYNAWLSYE
EEECCCCCCEEEEEE		12.9822817900
613UbiquitinationWLSYELQPAAGGARI
EEEEEECCCCCCCCC		36.3833845483
629PhosphorylationFRVGLYTGEISTTRV
EEEEEECCCCCCCEE		19.3832142685
660PhosphorylationDHGEPALTATATVLV
CCCCCCEEEEEEEHH		24.86-
662PhosphorylationGEPALTATATVLVSL
CCCCEEEEEEEHHHH		20.02-
664PhosphorylationPALTATATVLVSLVE
CCEEEEEEEHHHHHH		15.26-
679PhosphorylationSGQAPKASSRASVGV
CCCCCCCCCCCEECC		26.87-
680PhosphorylationGQAPKASSRASVGVA
CCCCCCCCCCEECCC		36.40-
747PhosphorylationVCSSALGSWSNSQQR
EEECCCCCCCCHHHH		28.3429900121
808PhosphorylationQPNPDWRYSASLRAG
CCCCCCCCEEHHHCC		12.34-
809PhosphorylationPNPDWRYSASLRAGM
CCCCCCCEEHHHCCC		11.6524719451
811PhosphorylationPDWRYSASLRAGMHS
CCCCCEEHHHCCCCC		16.6724719451
818PhosphorylationSLRAGMHSSVHLEEA
HHHCCCCCCEEHHHC		25.7628857561
819PhosphorylationLRAGMHSSVHLEEAG
HHCCCCCCEEHHHCC		10.0124719451
877UbiquitinationKYGPGNPKQSGPGEL
ECCCCCCCCCCCCCC		62.1833845483
893PhosphorylationDKFIIPGSPAIISIR
CCEEECCCCEEEEEE		13.0527050516
898PhosphorylationPGSPAIISIRQEPTN
CCCCEEEEEECCCCC		12.9527732954
904PhosphorylationISIRQEPTNSQIDKS
EEEECCCCCCCCCHH		46.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCDA1_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDA1_HUMAN

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Related Literatures of Post-Translational Modification

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