PCDA9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDA9_HUMAN
• UniProt AC: Q9Y5H5
• Protein Name: Protocadherin alpha-9
• Gene Name: PCDHA9
• Organism: Homo sapiens (Human).
• Sequence Length: 950
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MLYSSRGDPEGQPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVESGQAPKSSSRASVGATGPEVTLVDVNVYLIIAICAVSSLLVLTLLLYTVLRCSAMPTEGECAPGKPTLVCSSAVGSWSYSQQRRQRVCSGEGKQKTDLMAFSPGLSPCAGSTERTGEPSASSDSTGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
245	Phosphorylation	NAPVFDRTLYTVKLP CCCCCEEEEEEEECC	26.43	22210691
254	N-linked_Glycosylation	YTVKLPENVSIGTLV EEEECCCCEEEEEEE	30.78	UniProtKB CARBOHYD
265	N-linked_Glycosylation	GTLVIHPNASDLDEG EEEEECCCHHHCCCC	37.60	UniProtKB CARBOHYD
267	Phosphorylation	LVIHPNASDLDEGLN EEECCCHHHCCCCCC	45.40	22210691
283	Phosphorylation	DIIYSFSSDVSPDIK CEEEEECCCCCCCHH	39.77	22210691
299	Phosphorylation	KFHMDPLSGAITVIG HCCCCCCCCCEEEEE	31.41	28787133
303	Phosphorylation	DPLSGAITVIGHMDF CCCCCCEEEEECCCH	12.92	23607784
313	Phosphorylation	GHMDFEESRAHKIPV ECCCHHHHHCCCCCH	27.80	24850871
432	Phosphorylation	VTARDGGSPSLWATA EEECCCCCCCCEEEE	19.49	-
514	Phosphorylation	YVSVHAESGKVYALQ EEEEEECCCCEEEEC	44.70	-
548	N-linked_Glycosylation	GVPPLGSNVTLQVFV CCCCCCCCEEEEEEE	29.06	UniProtKB CARBOHYD
584	Phosphorylation	VSEMVLRSVGAGVVV HHHHHHHHHCCCEEE	22.27	24719451
603	Phosphorylation	AVDADSGYNAWLSYE EEECCCCCCEEEEEE	12.98	22817900
660	Phosphorylation	DHGEPALTATATVLV CCCCCCCEEEEEEHH	24.86	-
662	Phosphorylation	GEPALTATATVLVSL CCCCCEEEEEEHHHH	20.02	-
664	Phosphorylation	PALTATATVLVSLVE CCCEEEEEEHHHHHH	15.26	-
738	Phosphorylation	ECAPGKPTLVCSSAV CCCCCCCEEEEECCC	35.00	-
743	Phosphorylation	KPTLVCSSAVGSWSY CCEEEEECCCCCCCH	23.11	22468782
747	Phosphorylation	VCSSAVGSWSYSQQR EEECCCCCCCHHHHH	13.27	22210691
749	Phosphorylation	SSAVGSWSYSQQRRQ ECCCCCCCHHHHHHH	19.32	22210691
750	Phosphorylation	SAVGSWSYSQQRRQR CCCCCCCHHHHHHHH	12.30	28857561
751	Phosphorylation	AVGSWSYSQQRRQRV CCCCCCHHHHHHHHH	17.83	28857561
786	Phosphorylation	CAGSTERTGEPSASS CCCCCCCCCCCCCCC	39.40	23532336
790	Phosphorylation	TERTGEPSASSDSTG CCCCCCCCCCCCCCC	36.16	23532336
808	Phosphorylation	QPNPDWRYSASLRAG CCCCCCCCEEHHHCC	12.34	-
809	Phosphorylation	PNPDWRYSASLRAGM CCCCCCCEEHHHCCC	11.65	24719451
811	Phosphorylation	PDWRYSASLRAGMHS CCCCCEEHHHCCCCC	16.67	24719451
818	Phosphorylation	SLRAGMHSSVHLEEA HHHCCCCCCEEHHHC	25.76	28857561
819	Phosphorylation	LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC	10.01	24719451
877	Ubiquitination	KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC	62.18	33845483
893	Phosphorylation	DKFIIPGSPAIISIR CCEEECCCCEEEEEE	13.05	27050516
898	Phosphorylation	PGSPAIISIRQEPTN CCCCEEEEEECCCCC	12.95	27732954
904	Phosphorylation	ISIRQEPTNSQIDKS EEEECCCCCCCCCHH	46.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDA9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDA9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDA9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDA7_HUMAN	PCDHA7	physical	28514442
DCMC_HUMAN	MLYCD	physical	28514442
LONP2_HUMAN	LONP2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.