KCNS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNS3_HUMAN
• UniProt AC: Q9BQ31
• Protein Name: Potassium voltage-gated channel subfamily S member 3
• Gene Name: KCNS3
• Organism: Homo sapiens (Human).
• Sequence Length: 491
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328).
• Protein Description: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. [PubMed: 10484328 Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity]
• Protein Sequence: MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
312	Phosphorylation	RHSVGLRSLGATLRH HHCCCHHHHHHHHCC	35.88	21964256
316	Phosphorylation	GLRSLGATLRHSYHE CHHHHHHHHCCCHHH	23.64	21964256

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNS3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNS3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNB1_HUMAN	KCNB1	physical	9362476
SUCO_HUMAN	SUCO	physical	28514442
TAPT1_HUMAN	TAPT1	physical	28514442
KCNQ5_HUMAN	KCNQ5	physical	28514442
TAOK2_HUMAN	TAOK2	physical	28514442
C2C2L_HUMAN	C2CD2L	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
KCNB2_HUMAN	KCNB2	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
DJC18_HUMAN	DNAJC18	physical	28514442
REEP4_HUMAN	REEP4	physical	28514442
FIGL1_HUMAN	FIGNL1	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
RHDF2_HUMAN	RHBDF2	physical	28514442
AN13C_HUMAN	ANKRD13C	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
HYEP_HUMAN	EPHX1	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
FNTB_HUMAN	FNTB	physical	28514442
UBB_HUMAN	UBB	physical	28514442
PDE3B_HUMAN	PDE3B	physical	28514442
F189B_HUMAN	FAM189B	physical	28514442
HMDH_HUMAN	HMGCR	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
SUN1_HUMAN	SUN1	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
PLD6_HUMAN	PLD6	physical	28514442
PLPL6_HUMAN	PNPLA6	physical	28514442
RETST_HUMAN	RETSAT	physical	28514442
UPK3L_HUMAN	UPK3BL	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.