| UniProt ID | AN13C_HUMAN | |
|---|---|---|
| UniProt AC | Q8N6S4 | |
| Protein Name | Ankyrin repeat domain-containing protein 13C | |
| Gene Name | ANKRD13C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 541 | |
| Subcellular Localization | Endoplasmic reticulum membrane . Associated with the cytosolic side. | |
| Protein Description | Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.. | |
| Protein Sequence | MTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKVYQRIHHEESEMETEEEVDILMSSDIYSATLSTKSISFTRAQTGWLFREDKTERVGNFLADFYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIMEQNFEPIRRQSLTPPPQNTITWEEYISAENGKAPHLGRELVCKESKKTFKATIAMSQEFPLGIELLLNVLEVVAPFKHFNKLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRYDEFDGSIFTIPDDYKEDPSRFPDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MTGEKIRSLRRDHKP CCHHHHHHHCCCCCC | 29.69 | 24719451 | |
| 16 | Phosphorylation | LRRDHKPSKEEGDLL HCCCCCCCHHCCCCC | 58.46 | 28555341 | |
| 129 | Phosphorylation | KGDVRRLSSLIRTHN CCCHHHHHHHHHHCC | 22.68 | 21857030 | |
| 130 | Phosphorylation | GDVRRLSSLIRTHNI CCHHHHHHHHHHCCC | 32.19 | 24719451 | |
| 171 | Ubiquitination | LAHNAPVKVKNAQGW HHCCCCCEEECCCCC | 46.57 | 22817900 | |
| 173 | Ubiquitination | HNAPVKVKNAQGWSP CCCCCEEECCCCCCH | 40.63 | 22817900 | |
| 173 (in isoform 1) | Ubiquitination | - | 40.63 | 21906983 | |
| 194 | Phosphorylation | YGDRQMITALLRKLK HHHHHHHHHHHHHHH | 13.10 | 24719451 | |
| 271 | Ubiquitination | LIDFTDMKCQRGDLS EEECCCCEECCCCEE | 29.99 | - | |
| 387 | Ubiquitination | EEDILRNKAIMESLS HHHHHHCHHHHHHHH | 32.62 | 29967540 | |
| 395 | Ubiquitination | AIMESLSKGGNIMEQ HHHHHHHHCCCHHHC | 75.92 | 29967540 | |
| 411 | Phosphorylation | FEPIRRQSLTPPPQN CCCHHHCCCCCCCCC | 32.19 | 27251275 | |
| 413 | Phosphorylation | PIRRQSLTPPPQNTI CHHHCCCCCCCCCCC | 38.71 | 26471730 | |
| 419 | Phosphorylation | LTPPPQNTITWEEYI CCCCCCCCCCHHHHH | 17.97 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AN13C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AN13C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AN13C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PD2R_HUMAN | PTGDR | physical | 20959461 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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