| UniProt ID | PD2R_HUMAN | |
|---|---|---|
| UniProt AC | Q13258 | |
| Protein Name | Prostaglandin D2 receptor | |
| Gene Name | PTGDR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 359 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).. | |
| Protein Sequence | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | N-linked_Glycosylation | SPFYRCQNTTSVEKG CCCCCCCCCCCHHCC | 49.29 | UniProtKB CARBOHYD | |
| 12 | Phosphorylation | FYRCQNTTSVEKGNS CCCCCCCCCHHCCCC | 38.02 | 33259812 | |
| 90 | N-linked_Glycosylation | VLAAYAQNRSLRVLA HHHHHHCCCCHHHHH | 27.60 | UniProtKB CARBOHYD | |
| 254 | Phosphorylation | RADGREASPQPLEEL CCCCCCCCCCCHHHH | 21.22 | - | |
| 297 | N-linked_Glycosylation | FKDVKEKNRTSEEAE HHCHHHHCCCCHHHH | 54.26 | UniProtKB CARBOHYD | |
| 347 | Phosphorylation | IRPLRYRSRCSNSTN HHHHHHHHCCCCCCC | 28.80 | - | |
| 352 | Phosphorylation | YRSRCSNSTNMESSL HHHCCCCCCCCCCCC | 12.59 | - | |
| 353 | Phosphorylation | RSRCSNSTNMESSL- HHCCCCCCCCCCCC- | 42.72 | - | |
| 357 | Phosphorylation | SNSTNMESSL----- CCCCCCCCCC----- | 26.60 | - | |
| 358 | Phosphorylation | NSTNMESSL------ CCCCCCCCC------ | 25.45 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PD2R_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PD2R_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PD2R_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| AN13C_HUMAN | ANKRD13C | physical | 20959461 | |
| AN13C_HUMAN | ANKRD13C | physical | 23762421 | |
| PTGDS_HUMAN | PTGDS | physical | 24493589 | |
| HS90A_HUMAN | HSP90AA1 | physical | 24493589 | |
| MK01_HUMAN | MAPK1 | physical | 24493589 | |
| MK03_HUMAN | MAPK3 | physical | 24493589 | |
| PD2R2_HUMAN | PTGDR2 | physical | 21930295 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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