PD2R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PD2R2_HUMAN
• UniProt AC: Q9Y5Y4
• Protein Name: Prostaglandin D2 receptor 2
• Gene Name: PTGDR2
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Internalized receptors colocalized with RAB11A.
• Protein Description: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses..
• Protein Sequence: MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MSANATLKPLC ----CCCCCCHHCHH	26.59	UniProtKB CARBOHYD
25	N-linked_Glycosylation	SRLQSHSNTSIRYID HHHHCCCCCCCHHHH	32.21	UniProtKB CARBOHYD
183	Phosphorylation	LDGRIMCYYNVLLLN CCCEEEEEEEEEECC	4.82	23401153
184	Phosphorylation	DGRIMCYYNVLLLNP CCEEEEEEEEEECCC	8.21	23401153
201	Phosphorylation	DRDATCNSRQVALAV CCCCCCCHHHHHHHH	26.66	23401153
321	Phosphorylation	KLRRSLRTVLESVLV HHHHHHHHHHHHHHC	34.43	29978859
325	Phosphorylation	SLRTVLESVLVDDSE HHHHHHHHHHCCHHH	19.32	29978859
331	Phosphorylation	ESVLVDDSELGGAGS HHHHCCHHHCCCCCC	30.20	28674151
338	Phosphorylation	SELGGAGSSRRRRTS HHCCCCCCCCCCCCC	21.82	29978859
339	Phosphorylation	ELGGAGSSRRRRTSS HCCCCCCCCCCCCCC	28.96	29978859
345	Phosphorylation	SSRRRRTSSTARSAS CCCCCCCCCCCCCCC	24.71	-
350	Phosphorylation	RTSSTARSASPLALC CCCCCCCCCCCCHHC	30.54	23186163
352	Phosphorylation	SSTARSASPLALCSR CCCCCCCCCCHHCCC	22.99	23401153
358	Phosphorylation	ASPLALCSRPEEPRG CCCCHHCCCCCCCCC	52.28	23186163
376	Phosphorylation	LLGWLLGSCAASPQT HHHHHHHHHCCCCCC	10.68	-
380	Phosphorylation	LLGSCAASPQTGPLN HHHHHCCCCCCCHHH	10.06	-
383	Phosphorylation	SCAASPQTGPLNRAL HHCCCCCCCHHHHHH	44.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PD2R2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PD2R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PD2R2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AN13C_HUMAN	ANKRD13C	physical	20959461
RNF5_HUMAN	RNF5	physical	23798571
JKAMP_HUMAN	JKAMP	physical	23798571
PD2R_HUMAN	PTGDR	physical	21930295

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.