ALPK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALPK1_HUMAN
• UniProt AC: Q96QP1
• Protein Name: Alpha-protein kinase 1
• Gene Name: ALPK1
• Organism: Homo sapiens (Human).
• Sequence Length: 1244
• Protein Description: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation..
• Protein Sequence: MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Phosphorylation	GLQQLLASLRASILA HHHHHHHHHHHHHHH	20.54	24719451
98	Phosphorylation	LLASLRASILARDCA HHHHHHHHHHHHHHH	16.23	24719451
119	Phosphorylation	FLVDRFLYGLDVSGK HHHHHHHHCCCCCHH	16.96	46162729
124	Phosphorylation	FLYGLDVSGKLLQVA HHHCCCCCHHHHHHH	29.85	46162717
166	Phosphorylation	GKLLKAEYILSSLIS CCHHHHHHHHHHHHH	16.42	29978859
169	Phosphorylation	LKAEYILSSLISNNG HHHHHHHHHHHHCCC	17.34	29978859
170	Phosphorylation	KAEYILSSLISNNGA HHHHHHHHHHHCCCC	26.69	29978859
173	Phosphorylation	YILSSLISNNGATGT HHHHHHHHCCCCCCE	29.54	29978859
178	Phosphorylation	LISNNGATGTWLYRN HHHCCCCCCEEEEEC	36.22	29978859
180	Phosphorylation	SNNGATGTWLYRNES HCCCCCCEEEEECCC	14.14	29978859
183	Phosphorylation	GATGTWLYRNESDKV CCCCEEEEECCCCCE	11.71	29978859
237	Phosphorylation	PDKKGLSTSLGILAD CCCCCCCHHHHHHHH	32.77	46162723
266	Phosphorylation	NNPQINLSLLKEFDH CCCCCCHHHHHHHHH	27.45	24719451
398	Phosphorylation	NFSTSSRSQDREALS CCCCCCCHHCHHHHH	38.08	27251275
405	Phosphorylation	SQDREALSQEVMSVI HHCHHHHHHHHHHHH	31.20	25262027
410	Phosphorylation	ALSQEVMSVIAQVKE HHHHHHHHHHHHHHH	18.62	25262027
619	Phosphorylation	GKEHLVDTQCSTALS CCCHHCCCHHHHHHH	24.81	27251275
622	Phosphorylation	HLVDTQCSTALSEEL HHCCCHHHHHHHHHH	13.60	27251275
716	Phosphorylation	TSAHSRPSYRSASWS CCCCCCCCCCCCCCC	31.87	22322096
717	Phosphorylation	SAHSRPSYRSASWSS CCCCCCCCCCCCCCC	15.98	30850083
719	Phosphorylation	HSRPSYRSASWSSDS CCCCCCCCCCCCCCC	20.58	28857561
721	Phosphorylation	RPSYRSASWSSDSGR CCCCCCCCCCCCCCC	28.83	28857561
723	Phosphorylation	SYRSASWSSDSGRPK CCCCCCCCCCCCCCC	23.05	23312004
724	Phosphorylation	YRSASWSSDSGRPKN CCCCCCCCCCCCCCC	29.54	23312004
726	Phosphorylation	SASWSSDSGRPKNMG CCCCCCCCCCCCCCC	38.35	23312004
737	Phosphorylation	KNMGTHPSVQKEEAF CCCCCCCCCCHHHHE	29.58	25849741
770	Phosphorylation	KEQGEEISERGAGPT HHHCHHCHHCCCCCC	25.23	23403867
781	Phosphorylation	AGPTFKASPSWVDPE CCCCCCCCCCCCCCC	21.76	25627689
783	Phosphorylation	PTFKASPSWVDPEGE CCCCCCCCCCCCCCC	36.92	28857561
809	Phosphorylation	FHRVLHNSLGNISML HHHHHHHCCCCEEEE	27.23	113332757
938	Phosphorylation	WLKSPAFSSGSSEGD EEECCCCCCCCCCCC	35.58	27251275
939	Phosphorylation	LKSPAFSSGSSEGDS EECCCCCCCCCCCCC	35.92	28348404
941	Phosphorylation	SPAFSSGSSEGDSPW CCCCCCCCCCCCCCC	27.45	28348404
942	Phosphorylation	PAFSSGSSEGDSPWS CCCCCCCCCCCCCCH	49.47	24719451
946	Phosphorylation	SGSSEGDSPWSYLNS CCCCCCCCCCHHHCC	38.84	28348404
949	Phosphorylation	SEGDSPWSYLNSSGS CCCCCCCHHHCCCCC	24.11	28348404
953	Phosphorylation	SPWSYLNSSGSSWVS CCCHHHCCCCCCCCC	33.22	28348404
954	Phosphorylation	PWSYLNSSGSSWVSL CCHHHCCCCCCCCCC	41.44	28348404
956	Phosphorylation	SYLNSSGSSWVSLPG HHHCCCCCCCCCCCH	23.99	28348404
957	Phosphorylation	YLNSSGSSWVSLPGK HHCCCCCCCCCCCHH	34.71	28348404
1012	Phosphorylation	SQLHRAHSALLLKYS HHHHHHHHHHHHHHC	21.45	24247654
1037	Phosphorylation	TIVYLGDYLTVKKKG HEECCCCCEEEEECC	11.50	142737
1233	Phosphorylation	NEICHRLSLTRPSME HHHHHHHCCCCCCCC	27.87	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALPK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALPK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALPK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOXE3_HUMAN	ALOXE3	physical	26186194
SG1D2_HUMAN	SCGB1D2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.