KLH10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH10_HUMAN
• UniProt AC: Q6JEL2
• Protein Name: Kelch-like protein 10
• Gene Name: KLHL10
• Organism: Homo sapiens (Human).
• Sequence Length: 608
• Subcellular Localization: Cytoplasm.
• Protein Description: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis..
• Protein Sequence: MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	PHMERKMSAMACEIF HHHHHHHHHHHHHHH	20.23	30622161
96	Phosphorylation	MMKLIIEYAYTRTVP HHHHHHHHHHHCCCC	8.42	-
98	Phosphorylation	KLIIEYAYTRTVPIT HHHHHHHHHCCCCCC	8.89	-
182	Phosphorylation	SAEFLELSVTELKDI CHHHHHCCHHHHHHH	20.02	26437602
184	Phosphorylation	EFLELSVTELKDIIE HHHHCCHHHHHHHHH	32.02	30622161
192	Acetylation	ELKDIIEKDELNVKQ HHHHHHHHCCCCCCH	46.20	12432543
223	Phosphorylation	QNRKQHISILLPKVR CCHHHHHHHHHHHHH	12.69	28555341
256	Acetylation	VKDSEECKPVIINAL CCCCHHCHHHHHHHH	45.67	25038526
275	Phosphorylation	DLNMNGPSNSDFTNP CCCCCCCCCCCCCCC	50.82	25693802
277	Phosphorylation	NMNGPSNSDFTNPLT CCCCCCCCCCCCCCC	38.14	25693802
280	Phosphorylation	GPSNSDFTNPLTRPR CCCCCCCCCCCCCCC	40.70	25693802
284	Phosphorylation	SDFTNPLTRPRLPYA CCCCCCCCCCCCCEE	39.63	25693802
363	Sumoylation	VKRFDPVKKTWHQVA CCCCCCCCCCCHHCC	50.28	-
363	Sumoylation	VKRFDPVKKTWHQVA CCCCCCCCCCCHHCC	50.28	-
501	Phosphorylation	LRSAEAYSPVANTWR CCCCCCCCCCCCCCC	21.68	-
599	Phosphorylation	ALRDEVKYSASTSTL CCCCEEEECCCCCCC	18.04	25693802
600	Phosphorylation	LRDEVKYSASTSTLP CCCEEEECCCCCCCC	15.27	30622161
602	Phosphorylation	DEVKYSASTSTLPV- CEEEECCCCCCCCC-	19.56	30622161
603	Phosphorylation	EVKYSASTSTLPV-- EEEECCCCCCCCC--	26.00	30622161
604	Phosphorylation	VKYSASTSTLPV--- EEECCCCCCCCC---	26.00	30622161
605	Phosphorylation	KYSASTSTLPV---- EECCCCCCCCC----	34.86	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FXL17_HUMAN	FBXL17	physical	28514442
CSN7A_HUMAN	COPS7A	physical	28514442
CSN2_HUMAN	COPS2	physical	28514442
CSN7B_HUMAN	COPS7B	physical	28514442
KIME_HUMAN	MVK	physical	28514442
ANM3_HUMAN	PRMT3	physical	28514442
CSN5_HUMAN	COPS5	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442
DNJB5_HUMAN	DNAJB5	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
CSN3_HUMAN	COPS3	physical	28514442
PSME4_HUMAN	PSME4	physical	28514442
CSN1_HUMAN	GPS1	physical	28514442
B2L11_HUMAN	BCL2L11	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442
SNX1_HUMAN	SNX1	physical	28514442
STAT2_HUMAN	STAT2	physical	28514442
CUL3_HUMAN	CUL3	physical	28514442
CSN4_HUMAN	COPS4	physical	28514442
SNX5_HUMAN	SNX5	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
UBXN1_HUMAN	UBXN1	physical	28514442
PDD2L_HUMAN	PDCD2L	physical	28514442
HOOK3_HUMAN	HOOK3	physical	28514442
SIMC1_HUMAN	SIMC1	physical	28514442
HERC4_HUMAN	HERC4	physical	28514442
BAG5_HUMAN	BAG5	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
MTO1_HUMAN	MTO1	physical	28514442
ABRX2_HUMAN	FAM175B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.