RAPSN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAPSN_HUMAN
• UniProt AC: Q13702
• Protein Name: 43 kDa receptor-associated protein of the synapse
• Gene Name: RAPSN
• Organism: Homo sapiens (Human).
• Sequence Length: 412
• Subcellular Localization: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasmic surface of postsynaptic membranes.
• Protein Description: Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin..
• Protein Sequence: MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGQDQTKQQ ------CCCHHHHHH	39.51	-
2	Myristoylation	------MGQDQTKQQ ------CCCHHHHHH	39.51	-
59	Phosphorylation	AHSEMGRYKEMLKFA HCHHCHHHHHHHCHH	12.93	21253578
115	Phosphorylation	TCLGLPGTRAGAQLG HHHCCCCCHHHHHHC	18.53	-
126	Phosphorylation	AQLGGQVSLSMGNAF HHHCCEEEECCCCHH	13.57	-
145	Phosphorylation	VFQKALESFEKALRY HHHHHHHHHHHHHHH	39.29	26846344
196	Phosphorylation	AAELVNNYGKGWSLK HHHHHHHCCCCCCHH	18.27	-
269	Phosphorylation	LETAFPRYDSAMSIM HHHHCCCHHHHHHHH	17.94	22210691
271	Phosphorylation	TAFPRYDSAMSIMTE HHCCCHHHHHHHHHH	19.55	22210691
277	Phosphorylation	DSAMSIMTEIGNRLG HHHHHHHHHHHHHHH	23.84	22210691
324	Phosphorylation	EEVGNKLSQLKLHCL HHHHHHHHHHHHHHH	34.77	24719451
405	Phosphorylation	SCPNCRRSSMKPGFV CCCCCCCCCCCCCCC	18.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL8	Q9P2G9	PMID:19158078

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAPSN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAPSN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAG1_HUMAN	DAG1	physical	7619516
HERC1_HUMAN	HERC1	physical	26186194

Drug and Disease Associations

• Kegg Disease
• H00770: Congenital myasthenic syndrome
• H00987: Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
• OMIM Disease
• 616326: Myasthenic syndrome, congenital, 11, associated with acetylcholine receptor deficiency (CMS11)
• 208150: Fetal akinesia deformation sequence (FADS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.