PAK6_HUMAN - dbPTM
PAK6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAK6_HUMAN
UniProt AC Q9NQU5
Protein Name Serine/threonine-protein kinase PAK 6
Gene Name PAK6
Organism Homo sapiens (Human).
Sequence Length 681
Subcellular Localization Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction.
Protein Description Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD..
Protein Sequence MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
69PhosphorylationVQLQPMKTVVRGSAM
EECCCCCEEECCCCC		20.2721712546
81PhosphorylationSAMPVDGYISGLLND
CCCCCCHHHHHHHHH		6.3522817900
83PhosphorylationMPVDGYISGLLNDIQ
CCCCHHHHHHHHHHH		18.2021712546
97PhosphorylationQKLSVISSNTLRGRS
HHHHHHCCCCCCCCC		23.7823898821
99PhosphorylationLSVISSNTLRGRSPT
HHHHCCCCCCCCCCC		21.5627050516
104PhosphorylationSNTLRGRSPTSRRRA
CCCCCCCCCCHHHHH		35.0428985074
106PhosphorylationTLRGRSPTSRRRAQS
CCCCCCCCHHHHHHH		35.7927282143
113PhosphorylationTSRRRAQSLGLLGDE
CHHHHHHHHCCCCCC		24.3428450419
129PhosphorylationWATDPDMYLQSPQSE
CCCCHHHCCCCCCCC		14.6827642862
132PhosphorylationDPDMYLQSPQSERTD
CHHHCCCCCCCCCCC		23.4725106551
135PhosphorylationMYLQSPQSERTDPHG
HCCCCCCCCCCCCCC		32.22-
138PhosphorylationQSPQSERTDPHGLYL
CCCCCCCCCCCCEEE		50.2426356563
144PhosphorylationRTDPHGLYLSCNGGT
CCCCCCEEEEECCCC		10.9326356563
146PhosphorylationDPHGLYLSCNGGTPA
CCCCEEEEECCCCCC		7.6226356563
165PhosphorylationMPWPEPQSPRVLPNG
CCCCCCCCCCCCCCC		25.9528188228
179PhosphorylationGLAAKAQSLGPAEFQ
CHHHHHHHHCHHHHC		39.9019664994
201PhosphorylationQLGACLQSSPPGASP
HHHHHHHCCCCCCCC		31.6828348404
202PhosphorylationLGACLQSSPPGASPP
HHHHHHCCCCCCCCC		23.3528348404
207PhosphorylationQSSPPGASPPTGTNR
HCCCCCCCCCCCCCH		37.0127050516
224PhosphorylationMKAAKHGSEEARPQS
HHCHHCCCCCCCCCC		31.7929449344
231PhosphorylationSEEARPQSCLVGSAT
CCCCCCCCCEECCCC		16.4625404012
236PhosphorylationPQSCLVGSATGRPGG
CCCCEECCCCCCCCC		18.3829449344
238PhosphorylationSCLVGSATGRPGGEG
CCEECCCCCCCCCCC		35.1129449344
246PhosphorylationGRPGGEGSPSPKTRE
CCCCCCCCCCCCCHH		20.2228985074
248PhosphorylationPGGEGSPSPKTRESS
CCCCCCCCCCCHHHH		40.5027794612
301PhosphorylationPQKDNPPSLVAKAQS
CCCCCCCCHHHHHHC		36.4125056879
308PhosphorylationSLVAKAQSLPSDQPV
CHHHHHHCCCCCCCC		47.2927050516
311PhosphorylationAKAQSLPSDQPVGTF
HHHHCCCCCCCCCEE		54.9228348404
317PhosphorylationPSDQPVGTFSPLTTS
CCCCCCCEECCCCCC		22.6024719451
319PhosphorylationDQPVGTFSPLTTSDT
CCCCCEECCCCCCCC		20.8828348404
322PhosphorylationVGTFSPLTTSDTSSP
CCEECCCCCCCCCCC		27.8628450419
323PhosphorylationGTFSPLTTSDTSSPQ
CEECCCCCCCCCCCC		32.0828450419
324PhosphorylationTFSPLTTSDTSSPQK
EECCCCCCCCCCCCH		33.3928450419
326PhosphorylationSPLTTSDTSSPQKSL
CCCCCCCCCCCCHHC		30.7628450419
327PhosphorylationPLTTSDTSSPQKSLR
CCCCCCCCCCCHHCC		45.0428450419
328PhosphorylationLTTSDTSSPQKSLRT
CCCCCCCCCCHHCCC		33.1828450419
335PhosphorylationSPQKSLRTAPATGQL
CCCHHCCCCCCCCCC		42.1428450419
339PhosphorylationSLRTAPATGQLPGRS
HCCCCCCCCCCCCCC		25.1328152594
346PhosphorylationTGQLPGRSSPAGSPR
CCCCCCCCCCCCCCC		46.7328176443
347PhosphorylationGQLPGRSSPAGSPRT
CCCCCCCCCCCCCCE		19.8728176443
351PhosphorylationGRSSPAGSPRTWHAQ
CCCCCCCCCCEEEEE		17.2028176443
354PhosphorylationSPAGSPRTWHAQIST
CCCCCCCEEEEEEEC		25.6127642862
360PhosphorylationRTWHAQISTSNLYLP
CEEEEEEECCCEECC		17.4427642862
361PhosphorylationTWHAQISTSNLYLPQ
EEEEEEECCCEECCC		24.2223898821
362PhosphorylationWHAQISTSNLYLPQD
EEEEEECCCEECCCC		20.3227251275
365PhosphorylationQISTSNLYLPQDPTV
EEECCCEECCCCCCC		22.1627642862
371PhosphorylationLYLPQDPTVAKGALA
EECCCCCCCCCCCCC		41.19-
528UbiquitinationGVIHRDIKSDSILLT
CCCCCCCCCCEEEEE		53.12-
560PhosphorylationKDVPKRKSLVGTPYW
CCCCCCHHCCCCCCC		32.1122322096
564PhosphorylationKRKSLVGTPYWMAPE
CCHHCCCCCCCCCHH		13.0125106551
566PhosphorylationKSLVGTPYWMAPEVI
HHCCCCCCCCCHHHH		13.9828176443
574PhosphorylationWMAPEVISRSLYATE
CCCHHHHHHHHCCCH		22.4628176443
574 (in isoform 2)Phosphorylation-22.4622210691
576 (in isoform 2)Phosphorylation-20.9522210691
580 (in isoform 2)Phosphorylation-24.0022210691
616PhosphorylationAMKRLRDSPPPKLKN
HHHHHHCCCCCCCCC		32.6428985074
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
165SPhosphorylationKinaseMAPK14Q16539
GPS
564TPhosphorylationKinaseMAP2K6P52564
GPS
566YPhosphorylationKinaseMAP2K6P52564
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAK6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAK6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ESR1_HUMANESR1physical
11773441
MK14_HUMANMAPK14physical
21900206
A4_HUMANAPPphysical
21832049
ANDR_HUMANARphysical
23132866
MDM2_HUMANMDM2physical
23132866
SNX2_HUMANSNX2physical
21988832
TPD53_HUMANTPD52L1physical
21988832
SEM3B_HUMANSEMA3Bphysical
21988832
RAC1_HUMANRAC1physical
25301945
RHOJ_HUMANRHOJphysical
25416956
1433G_HUMANYWHAGphysical
28514442
1433Z_HUMANYWHAZphysical
28514442
1433E_HUMANYWHAEphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAK6_HUMAN

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Related Literatures of Post-Translational Modification

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