RGS6_HUMAN - dbPTM
RGS6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGS6_HUMAN
UniProt AC P49758
Protein Name Regulator of G-protein signaling 6
Gene Name RGS6
Organism Homo sapiens (Human).
Sequence Length 472
Subcellular Localization Cytoplasm . Cytoplasm, cytosol . Membrane
Peripheral membrane protein . Nucleus . Cell membrane . Interaction with GNB5 mediates translocation to the nucleus.
Protein Description Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity. [PubMed: 10521509]
Protein Sequence MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAQGSGDQRAVG
---CCCCCCCCCCCC		27.4126434776
19PhosphorylationGVADPEESSPNMIVY
CCCCCCCCCCCEEEE		49.8126434776
20PhosphorylationVADPEESSPNMIVYC
CCCCCCCCCCEEEEE		24.4726434776
26PhosphorylationSSPNMIVYCKIEDII
CCCCEEEEEEHHHHH		4.1526434776
34PhosphorylationCKIEDIITKMQDDKT
EEHHHHHHHHCCCCC		22.3126434776
237PhosphorylationKKSVYGVTEESQAQS
HHHHHCCCCHHHCCC		29.6724076635
244PhosphorylationTEESQAQSPVHVLSQ
CCHHHCCCCCCHHCC		31.7224076635
257PhosphorylationSQPIRKTTKEDIRKQ
CCCCCCCCHHHHHHH		35.1629457462
285 (in isoform 6)Phosphorylation-18.4827174698
285 (in isoform 7)Phosphorylation-18.4827174698
285 (in isoform 9)Phosphorylation-18.4827174698
285 (in isoform 11)Phosphorylation-18.4827174698
285 (in isoform 10)Phosphorylation-18.4827174698
289 (in isoform 6)Phosphorylation-12.1027174698
289 (in isoform 11)Phosphorylation-12.1027174698
289 (in isoform 9)Phosphorylation-12.1027174698
289 (in isoform 10)Phosphorylation-12.1027174698
289 (in isoform 7)Phosphorylation-12.1027174698
320 (in isoform 12)Phosphorylation-34.6222210691
326 (in isoform 12)Phosphorylation-39.7822210691
327 (in isoform 12)Phosphorylation-45.9022210691
332 (in isoform 12)Phosphorylation-35.5722210691
422 (in isoform 10)Phosphorylation-6.2422210691
422 (in isoform 9)Phosphorylation-6.2422210691
428 (in isoform 10)Phosphorylation-19.3222210691
428 (in isoform 9)Phosphorylation-19.3222210691
429 (in isoform 10)Phosphorylation-2.9722210691
429 (in isoform 9)Phosphorylation-2.9722210691
434 (in isoform 9)Phosphorylation-62.6422210691
434 (in isoform 10)Phosphorylation-62.6422210691
459 (in isoform 15)Phosphorylation-31.9222210691
459PhosphorylationLAKKKGKSLAGKRLT
HHHHCCCCCCHHHHH		31.92-
459 (in isoform 2)Phosphorylation-31.9222210691
459 (in isoform 13)Phosphorylation-31.9222210691
459 (in isoform 14)Phosphorylation-31.9222210691
459 (in isoform 3)Phosphorylation-31.9222210691
465 (in isoform 15)Phosphorylation-5.1922210691
465 (in isoform 13)Phosphorylation-5.1922210691
465 (in isoform 14)Phosphorylation-5.1922210691
465 (in isoform 3)Phosphorylation-5.1922210691
465 (in isoform 2)Phosphorylation-5.1922210691
466 (in isoform 3)Phosphorylation-32.1022210691
466 (in isoform 14)Phosphorylation-32.1022210691
466 (in isoform 13)Phosphorylation-32.1022210691
466 (in isoform 2)Phosphorylation-32.1022210691
466 (in isoform 15)Phosphorylation-32.1022210691
471 (in isoform 3)Phosphorylation-24.8522210691
471 (in isoform 14)Phosphorylation-24.8522210691
471 (in isoform 2)Phosphorylation-24.8522210691
471 (in isoform 13)Phosphorylation-24.8522210691
471 (in isoform 15)Phosphorylation-24.8522210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGS6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGS6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGS6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DMAP1_HUMANDMAP1physical
14734556
DNMT1_HUMANDNMT1physical
14734556
STMN2_HUMANSTMN2physical
12140291
GNB5_HUMANGNB5physical
10521509
GBB1_HUMANGNB1physical
10339615
GBB2_HUMANGNB2physical
10339615
GBB3_HUMANGNB3physical
10339615
GBB4_HUMANGNB4physical
10339615
GNB5_HUMANGNB5physical
10339615
GNB5_HUMANGNB5physical
28514442
CC85B_HUMANCCDC85Bphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGS6_HUMAN

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Related Literatures of Post-Translational Modification

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