MYO3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO3B_HUMAN
• UniProt AC: Q8WXR4
• Protein Name: Myosin-IIIb
• Gene Name: MYO3B
• Organism: Homo sapiens (Human).
• Sequence Length: 1341
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, stereocilium .
• Protein Description: Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments..
• Protein Sequence: MKHLYGLFHYNPMMLGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEENNSAHPSFFSSSSKGDSFAQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
194	Phosphorylation	RRNTSVGTPFWMAPE CCCCCCCCCCCCCCC	17.10	-
489	Phosphorylation	CTAINDNSSRFGKYL CEECCCCCCHHHHHH	26.25	29514088
490	Phosphorylation	TAINDNSSRFGKYLE EECCCCCCHHHHHHH	37.57	29514088
495	Phosphorylation	NSSRFGKYLEMMFTP CCCHHHHHHHHCCCC	14.31	22817900
514	Phosphorylation	MGARISEYLLEKSRV CCHHHHHHHHHHHHH	15.14	22817900
518	Ubiquitination	ISEYLLEKSRVIKQA HHHHHHHHHHHHHHH	43.46	-
573	Phosphorylation	GRVMHDITSKESYRR CCCCCCCCCHHHHHH	39.54	22210691
574	Phosphorylation	RVMHDITSKESYRRQ CCCCCCCCHHHHHHH	34.46	22210691
894	Phosphorylation	AQTRARITVASSSLP HHHEEEEEEECCCCC	12.41	22210691
897	Phosphorylation	RARITVASSSLPPHF EEEEEEECCCCCCCC	19.00	23403867
898	Phosphorylation	ARITVASSSLPPHFS EEEEEECCCCCCCCC	26.59	22210691
899	Phosphorylation	RITVASSSLPPHFSA EEEEECCCCCCCCCC	42.26	23403867
905	Phosphorylation	SSLPPHFSAGKAKVD CCCCCCCCCCCCEEC	32.83	22210691
908	Ubiquitination	PPHFSAGKAKVDTLE CCCCCCCCCEECEEE	44.76	2097226
908 (in isoform 4)	Ubiquitination	-	44.76	20972266
938	Phosphorylation	VASYFRYSLMDLLSK HHHHHHHHHHHHHHH	16.98	24719451
979	Phosphorylation	RVLAQLRSTGILETV HHHHHHHHCCCEEEE	39.31	19664994
980	Phosphorylation	VLAQLRSTGILETVS HHHHHHHCCCEEEEE	23.08	19664994
993	Phosphorylation	VSIRRQGYSHRILFE EEECCCCCCCHHHHH	7.93	22817900
1012	Phosphorylation	RYYYLAFTAHQTPLA HHHHHHHCCCCCCCC	20.02	30257219
1016	Phosphorylation	LAFTAHQTPLASKES HHHCCCCCCCCCHHH	15.48	30257219
1020	Phosphorylation	AHQTPLASKESCVAI CCCCCCCCHHHHHHH	44.64	30257219
1030	Ubiquitination	SCVAILEKSRLDHWV HHHHHHHHHCCCHHH	37.11	-
1096	Phosphorylation	KGAIAIQSAWRGYDA HCCHHHHHHCCCHHH	24.56	-
1101	Phosphorylation	IQSAWRGYDARRKFK HHHHCCCHHHHHHHH	9.61	-
1117	Phosphorylation	ISNRRNESAAHNQAG HHHCCCHHHHHHCCC	34.01	-
1135	Phosphorylation	NQSSGPHSPVAAGTR CCCCCCCCCCCCCCC	24.97	24719451
1162	Phosphorylation	DHKVLRGSVHRRSHS CCEEECCCCCCCCCC	14.33	-
1167	Phosphorylation	RGSVHRRSHSQAESN CCCCCCCCCCCCCCC	27.70	-
1169	Phosphorylation	SVHRRSHSQAESNNG CCCCCCCCCCCCCCC	32.12	-
1173	Phosphorylation	RSHSQAESNNGRTQT CCCCCCCCCCCCCCC	38.31	-
1184	Phosphorylation	RTQTSSNSPAVTEKN CCCCCCCCCCCCCCC	19.04	-
1188	Phosphorylation	SSNSPAVTEKNGHSQ CCCCCCCCCCCCCCC	43.26	-
1205 (in isoform 5)	Phosphorylation	-	2.72	22210691
1219 (in isoform 5)	Phosphorylation	-	49.49	22210691
1222	Phosphorylation	VSGTDLLSSRICHPA CCCHHHCCCCCCCCC	25.52	24719451
1223	Phosphorylation	SGTDLLSSRICHPAP CCHHHCCCCCCCCCC	26.15	24719451
1226 (in isoform 5)	Phosphorylation	-	2.82	22210691
1269	Phosphorylation	QQPKMLSSPEDTMYY CCCCCCCCCCHHCHH	28.48	30576142
1273	Phosphorylation	MLSSPEDTMYYNQLN CCCCCCHHCHHHHHC	12.86	24719451
1282	Phosphorylation	YYNQLNGTLEYQGSK HHHHHCCCEEECCCC	18.49	24719451
1285	Phosphorylation	QLNGTLEYQGSKRKP HHCCCEEECCCCCCC	22.68	30576142
1310	Phosphorylation	GEDEYYKSLSPVDCI CCCCCHHCCCCCCCC	20.25	27080861
1312	Phosphorylation	DEYYKSLSPVDCIPE CCCHHCCCCCCCCCC	29.93	27080861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO3B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO3B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.