FBX40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX40_HUMAN
• UniProt AC: Q9UH90
• Protein Name: F-box only protein 40
• Gene Name: FBXO40
• Organism: Homo sapiens (Human).
• Sequence Length: 709
• Subcellular Localization: Cytoplasm.
• Protein Description: Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis..
• Protein Sequence: MGKARRSPPGHHRHCEGCFNRHCHIPVEPNTSCLVISCHLLCGATFHMCKEAEHQLLCPLEQVPCLNSEYGCPLSMSRHKLAKHLQVCPASVVCCSMEWNRWPNVDSETTLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETREATEEEPTMNGETSVEEMGGAVGGVDIGLVPHGLSATNGEMAELSQEEREVLAKTKEGMDLVKFGQWENIFSKEHAASALTNSSASCESKNKNDSEKEQISSGHNMVEGEGAPKKKEPQENQKQQDVRTAMETTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGKLEAQEVKTVYTFKVPVSYCGKRARLGDAMLSCKPSEHKAVDTSDLGITVEDLPKSDLIKTTLQCALERELKGHVISESRSIDGLFMDFATQTYNFEPEQFSSGTVLADLTAATPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSCLNGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEGRKNNHLLGHGGKSQNSLTSLPLEILKYIAGFLDSVSLAQLSQVSVLMRNICATLLQERGMVLLQWKKKRYSHGGTSWRVHREIWQFSSLFSKIKSWEFNEVTSMSEHLKSCPFNIVEHKTDPILLTSMCQPREQARESLVSTFRIRPRGRYVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	VPCLNSEYGCPLSMS CCCCCCCCCCCCCCC	24.69	-
75	Phosphorylation	SEYGCPLSMSRHKLA CCCCCCCCCCHHHHH	10.39	-
77	Phosphorylation	YGCPLSMSRHKLAKH CCCCCCCCHHHHHHH	28.05	-
223	Phosphorylation	GQWENIFSKEHAASA CCHHHCCCHHHHHHH	33.08	24719451
246	Phosphorylation	ESKNKNDSEKEQISS HCCCCCHHHHHHHHH	61.02	26074081
252	Phosphorylation	DSEKEQISSGHNMVE HHHHHHHHHCCCCCC	29.93	26074081
253	Phosphorylation	SEKEQISSGHNMVEG HHHHHHHHCCCCCCC	45.78	26074081
265	Ubiquitination	VEGEGAPKKKEPQEN CCCCCCCCCCCCCHH	75.77	22817900
266	Ubiquitination	EGEGAPKKKEPQENQ CCCCCCCCCCCCHHH	62.40	22817900
267	Ubiquitination	GEGAPKKKEPQENQK CCCCCCCCCCCHHHC	79.39	22817900
346	Phosphorylation	LEAQEVKTVYTFKVP EEEEEEEEEEEEEEE	24.74	30177828
348	Phosphorylation	AQEVKTVYTFKVPVS EEEEEEEEEEEEEHH	16.22	30177828
349	Phosphorylation	QEVKTVYTFKVPVSY EEEEEEEEEEEEHHH	16.79	30177828
355	Phosphorylation	YTFKVPVSYCGKRAR EEEEEEHHHCCCCCC	14.50	30177828
356	Phosphorylation	TFKVPVSYCGKRARL EEEEEHHHCCCCCCC	12.88	30177828
380	Phosphorylation	SEHKAVDTSDLGITV CCCCCCCHHHCCCCH	19.97	-
393	Phosphorylation	TVEDLPKSDLIKTTL CHHHCCHHHHHHHHH	35.39	-
472	Phosphorylation	TRRHNKSSSAFTFTC ECCCCCCCCCEEEEE	27.56	-
583	Phosphorylation	LPLEILKYIAGFLDS HHHHHHHHHHHHHCC	7.80	-
592	Phosphorylation	AGFLDSVSLAQLSQV HHHHCCCCHHHHHHH	23.18	-
647	Phosphorylation	WQFSSLFSKIKSWEF HHHHHHHHHHHHCCH	38.47	24719451
651	Phosphorylation	SLFSKIKSWEFNEVT HHHHHHHHCCHHHCC	35.00	26503514
658	Phosphorylation	SWEFNEVTSMSEHLK HCCHHHCCCHHHHHH	16.72	26503514
659	Phosphorylation	WEFNEVTSMSEHLKS CCHHHCCCHHHHHHH	26.03	26503514
661	Phosphorylation	FNEVTSMSEHLKSCP HHHCCCHHHHHHHCC	22.95	26503514

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
MYO1D_HUMAN	MYO1D	physical	28514442
GELS_HUMAN	GSN	physical	28514442
SKP1_HUMAN	SKP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.