FBX17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX17_HUMAN
• UniProt AC: Q96EF6
• Protein Name: F-box only protein 17
• Gene Name: FBXO17
• Organism: Homo sapiens (Human).
• Sequence Length: 278
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins..
• Protein Sequence: MGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRPVCRAWRDIVDGPTVWLLQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLRAPFGRNLIFNSCGEQGFRGWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQLVDLVMEGVWQELLDSAQIEICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASPDPVLQWTERGCRQVSHVFTNFGKGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIRLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	SAEGRALYAVAQRCL CHHHHHHHHHHHHHC	9.69	27642862
257	Phosphorylation	QYGRDVSSWVGHYGA HHCCCHHHHHHHCCE	26.15	30387612
262	Phosphorylation	VSSWVGHYGALVTHS HHHHHHHCCEEEECC	9.73	30387612
270	Phosphorylation	GALVTHSSVRVRIRL CEEEECCEEEEEEEC	13.31	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	18203720
SKP1_HUMAN	SKP1	physical	18203720
RBX1_HUMAN	RBX1	physical	18203720
SKP1_HUMAN	SKP1	physical	21640084
CH60_HUMAN	HSPD1	physical	26186194
NMT1_HUMAN	NMT1	physical	26186194
NMT2_HUMAN	NMT2	physical	26186194
CSN2_HUMAN	COPS2	physical	26186194
NDUA2_HUMAN	NDUFA2	physical	26186194
CSN7B_HUMAN	COPS7B	physical	26186194
CSN4_HUMAN	COPS4	physical	26186194
SKP1_HUMAN	SKP1	physical	26186194
CUL1_HUMAN	CUL1	physical	26186194
CSN6_HUMAN	COPS6	physical	26186194
CLPP_HUMAN	CLPP	physical	26186194
SYSM_HUMAN	SARS2	physical	26186194
CSN5_HUMAN	COPS5	physical	26186194
FBXW2_HUMAN	FBXW2	physical	26186194
NDUS6_HUMAN	NDUFS6	physical	26186194
CSN2_HUMAN	COPS2	physical	28514442
FBXW2_HUMAN	FBXW2	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442
SKP1_HUMAN	SKP1	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
SYSM_HUMAN	SARS2	physical	28514442
CSN5_HUMAN	COPS5	physical	28514442
NMT1_HUMAN	NMT1	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
CSN4_HUMAN	COPS4	physical	28514442
CSN7B_HUMAN	COPS7B	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.