CD37L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD37L_HUMAN
• UniProt AC: Q7L3B6
• Protein Name: Hsp90 co-chaperone Cdc37-like 1
• Gene Name: CDC37L1
• Organism: Homo sapiens (Human).
• Sequence Length: 337
• Subcellular Localization: Cytoplasm .
• Protein Description: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90..
• Protein Sequence: MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQDKRKDTEDEDKSESFMQKYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	EGEAEEESDFDVFPS CCCCCCCCCCCCCCC	47.02	29396449
31	Phosphorylation	SDFDVFPSSPRCPQL CCCCCCCCCCCCCCC	41.32	25159151
32	Phosphorylation	DFDVFPSSPRCPQLP CCCCCCCCCCCCCCC	19.32	19664994
46	Phosphorylation	PGGGAQMYSHGIELA CCCCCHHHHHHHHHH	5.85	27642862
62	Methylation	QKQKEFVKSSVACKW HHHHHHHHHHHHHHC	42.19	-
62	Ubiquitination	QKQKEFVKSSVACKW HHHHHHHHHHHHHHC	42.19	-
77	Ubiquitination	NLAEAQQKLGSLALH CHHHHHHHHHHHHHH	42.61	29967540
80	Phosphorylation	EAQQKLGSLALHNSE HHHHHHHHHHHHCCC	22.39	28857561
86	Phosphorylation	GSLALHNSESLDQEH HHHHHHCCCCCCHHH	20.15	27050516
88	Phosphorylation	LALHNSESLDQEHAK HHHHCCCCCCHHHHH	36.75	22617229
95	Ubiquitination	SLDQEHAKAQTAVSE CCCHHHHHHHHHHHH	42.82	29967540
98	Phosphorylation	QEHAKAQTAVSELRQ HHHHHHHHHHHHHHH	33.61	17924679
101	Phosphorylation	AKAQTAVSELRQREE HHHHHHHHHHHHHHH	28.57	17924679
113	Ubiquitination	REEEWRQKEEALVQR HHHHHHHHHHHHHHH	49.28	29967540
138	Ubiquitination	ISKDVFNKSFINQDK CCHHHCCHHHCCCCC	34.97	29967540
139	Phosphorylation	SKDVFNKSFINQDKR CHHHCCHHHCCCCCC	32.25	28857561
260	Ubiquitination	EGYFEAFKNELEAFK CCHHHHHHHHHHHHH	57.47	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD37L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD37L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD37L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90B_HUMAN	HSP90AB1	physical	21988832
NIBAN_HUMAN	FAM129A	physical	22863883
K1468_HUMAN	KIAA1468	physical	22863883
UBAP1_HUMAN	UBAP1	physical	22863883
UBP25_HUMAN	USP25	physical	22863883
HS90B_HUMAN	HSP90AB1	physical	25036637
HS90A_HUMAN	HSP90AA1	physical	25036637
PPP5_HUMAN	PPP5C	physical	25036637
FKBP4_HUMAN	FKBP4	physical	25036637
TOM34_HUMAN	TOMM34	physical	25036637
UBP19_HUMAN	USP19	physical	25036637
CDC37_HUMAN	CDC37	physical	25036637
RS7_HUMAN	RPS7	physical	25036637
CHIP_HUMAN	STUB1	physical	25036637
TTC4_HUMAN	TTC4	physical	25036637
CHRD1_HUMAN	CHORDC1	physical	25036637
FKBP5_HUMAN	FKBP5	physical	25036637
RS17_HUMAN	RPS17	physical	25036637
GLMN_HUMAN	GLMN	physical	25036637
TMOD4_HUMAN	TMOD4	physical	25036637
STIP1_HUMAN	STIP1	physical	25036637
XPO1_HUMAN	XPO1	physical	25036637
HS90A_HUMAN	HSP90AA1	physical	11413142
STIP1_HUMAN	STIP1	physical	11413142

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND MASSSPECTROMETRY.
PubMed: 18669648

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-98 AND SER-101, AND MASSSPECTROMETRY.
PubMed: 17924679