TMOD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMOD4_HUMAN
• UniProt AC: Q9NZQ9
• Protein Name: Tropomodulin-4
• Gene Name: TMOD4
• Organism: Homo sapiens (Human).
• Sequence Length: 345
• Subcellular Localization: Cytoplasm, cytoskeleton . In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
• Protein Description: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton..
• Protein Sequence: MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDREALLQYLEQQALEVKERDDLVPFTGEKKGKPYIQPKREIPAEEQITLEPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSSYQKELEKY ----CCHHHHHHHHH	19.12	-
11	Phosphorylation	YQKELEKYRDIDEDE HHHHHHHHCCCCHHH	12.25	25262027
55	Phosphorylation	GLRQRDQTKKSPTGP HHHHHHCCCCCCCCC	44.74	-
58	Phosphorylation	QRDQTKKSPTGPLDR HHHCCCCCCCCCCCH	29.29	26437602
60	Phosphorylation	DQTKKSPTGPLDREA HCCCCCCCCCCCHHH	59.53	-
71	Phosphorylation	DREALLQYLEQQALE CHHHHHHHHHHHHCC	16.51	-
228	Phosphorylation	KANTYVRSFSLVATR HHCCCEEEEEEEEEC	14.78	26437602
230	Phosphorylation	NTYVRSFSLVATRSG CCCEEEEEEEEECCC	24.15	26437602
236	Phosphorylation	FSLVATRSGDPIANA EEEEEECCCCHHHHH	43.10	25072903
253	Phosphorylation	DMLRENRSLQSLNIE HHHHHCCCCCCCCCC	42.20	-
274	Acetylation	TGLMAVLKAVRENAT HHHHHHHHHHHHCCC	37.93	25443223

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMOD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMOD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMOD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEBU_HUMAN	NEB	physical	11016930
A4_HUMAN	APP	physical	21832049
LRRF1_HUMAN	LRRFIP1	physical	28514442
MTFR2_HUMAN	MTFR2	physical	28514442
HEMH_HUMAN	FECH	physical	28514442
LRRF2_HUMAN	LRRFIP2	physical	28514442
FLII_HUMAN	FLII	physical	28514442
MYO5A_HUMAN	MYO5A	physical	28514442
HEM1_HUMAN	ALAS1	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
NELFA_HUMAN	NELFA	physical	28514442
MYO5C_HUMAN	MYO5C	physical	28514442
GIT2_HUMAN	GIT2	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
MYO9A_HUMAN	MYO9A	physical	28514442
KANK2_HUMAN	KANK2	physical	28514442
HAUS5_HUMAN	HAUS5	physical	28514442
MYO9B_HUMAN	MYO9B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.