NAL12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAL12_HUMAN
• UniProt AC: P59046
• Protein Name: NACHT, LRR and PYD domains-containing protein 12
• Gene Name: NLRP12
• Organism: Homo sapiens (Human).
• Sequence Length: 1061
• Subcellular Localization: Cytoplasm.
• Protein Description: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK..
• Protein Sequence: MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	LLEVSLVTPRKDPQE EEEEEEECCCCCHHH	23.75	24719451
154	Phosphorylation	LGECVNLSHRYTRLL HHHHHCCHHHCCEEE	10.75	19369195
186	Phosphorylation	TGRGHARTVGHQASP CCCCCCCCCCCCCCC	31.46	23312004
192	Phosphorylation	RTVGHQASPIKIETL CCCCCCCCCCEEEEC	22.16	23312004
224	Phosphorylation	GAAGIGKSMLAHKVM CCCCCCHHHHHHHHH	17.51	-
326	Phosphorylation	PTELLLNSLIRKKLL CHHHHHHHHHHHHCH	25.74	24719451
430	Phosphorylation	LLRQTSRTTTAVYML CCCCCCHHHHHHHHH	28.41	25072903
431	Phosphorylation	LRQTSRTTTAVYMLY CCCCCHHHHHHHHHH	16.20	25072903
432	Phosphorylation	RQTSRTTTAVYMLYL CCCCHHHHHHHHHHH	17.32	25072903
435	Phosphorylation	SRTTTAVYMLYLLSL CHHHHHHHHHHHHHH	4.48	25072903
438	Phosphorylation	TTAVYMLYLLSLMQP HHHHHHHHHHHHHCC	6.78	25072903
441	Phosphorylation	VYMLYLLSLMQPKPG HHHHHHHHHHCCCCC	21.14	25072903
727	Phosphorylation	LYRNALGSRGVKLLC HHHHCCCHHHHHHHH	27.06	-
881	Phosphorylation	DELASTLSVNQSLRE HHHHHHCCCCHHHHH	21.07	23879269
979	Phosphorylation	LQKLWLDSCGLTAKA HHHHHHHHCCCHHHH	14.12	-
1020	Acetylation	TGVRLLCKRLSHPGC HHHHHHHHHCCCCCC	57.24	11792769

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAL12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAL12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAL12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAF1_HUMAN	FAF1	physical	17046979
HSP74_HUMAN	HSPA4	physical	17947705

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.