AMHR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMHR2_HUMAN
• UniProt AC: Q16671
• Protein Name: Anti-Muellerian hormone type-2 receptor
• Gene Name: AMHR2
• Organism: Homo sapiens (Human).
• Sequence Length: 573
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone..
• Protein Sequence: MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLGSLGLWALL ----CCCCHHHHHHC	18.46	22468782
13	Phosphorylation	GLWALLPTAVEAPPN HHHHHCCCCCCCCCC	43.22	22468782
58	Phosphorylation	RAIRCLYSRCCFGIW HHHHHHHHHHHHHHH	13.09	24719451
66	N-linked_Glycosylation	RCCFGIWNLTQDRAQ HHHHHHHHHCCCHHH	31.15	UniProtKB CARBOHYD
119	N-linked_Glycosylation	GTDFCNANYSHLPPP CCCCCCCCCCCCCCC	25.50	UniProtKB CARBOHYD
189	Phosphorylation	VPEPRPDSGRDWSVE CCCCCCCCCCCCEEE	38.11	-
236	Phosphorylation	IKAFPPRSVAQFQAE EEECCCCHHHHHHHH	27.81	27251275
422	Phosphorylation	LLLWEILSRCPDLRP HHHHHHHHCCCCCCC	37.18	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMHR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMHR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMHR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90A_HUMAN	HSP90AA1	physical	22939624

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.