MKX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MKX_HUMAN
• UniProt AC: Q8IYA7
• Protein Name: Homeobox protein Mohawk
• Gene Name: MKX
• Organism: Homo sapiens (Human).
• Sequence Length: 352
• Subcellular Localization: Nucleus .
• Protein Description: May act as a morphogenetic regulator of cell adhesion..
• Protein Sequence: MNTIVFNKLSGAVLFEDGGASERERGGRPYSGVLDSPHARPEVGIPDGPPLKDNLGLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSEDGENPPRTHMNEGGYNTPVHHPVIKSENSVIKAGVRPESRASEDYVAPPKYKSSLLNRYLNDSLRHVMATNTTMMGKTRQRNHSGSFSSNEFEEELVSPSSSETEGNFVYRTDTLENGSNKGESAANRKGPSKDDTYWKEINAAMALTNLAQGKDKLQGTTSCIIQKSSHIAEVKTVKVPLVQQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LFEDGGASERERGGR EECCCCCCHHHCCCC	40.22	30257219
30	Phosphorylation	RERGGRPYSGVLDSP HHCCCCCCCCCCCCC	19.39	22210691
31	Phosphorylation	ERGGRPYSGVLDSPH HCCCCCCCCCCCCCC	25.71	22210691
36	Phosphorylation	PYSGVLDSPHARPEV CCCCCCCCCCCCCCC	17.90	27251275
86	Acetylation	QDMARPLKQWLYKHR HHHHHHHHHHHHHCC	41.95	7364335
138	Phosphorylation	TVRQPDLSWALRIKL HCCCCCHHHHHHHHH	20.06	24719451
146	Phosphorylation	WALRIKLYNKYVQGN HHHHHHHHHHHHCCC	12.47	24719451
239	Phosphorylation	RHVMATNTTMMGKTR HHHHHCCCCCCCCCC	16.24	-
251	Phosphorylation	KTRQRNHSGSFSSNE CCCCCCCCCCCCCCH	39.42	27251275
253	Phosphorylation	RQRNHSGSFSSNEFE CCCCCCCCCCCCHHH	25.60	27251275
255	Phosphorylation	RNHSGSFSSNEFEEE CCCCCCCCCCHHHHH	33.67	27251275
256	Phosphorylation	NHSGSFSSNEFEEEL CCCCCCCCCHHHHHH	38.07	27251275
277	Phosphorylation	ETEGNFVYRTDTLEN CCCCCEEEEECCCCC	12.03	-
279	Phosphorylation	EGNFVYRTDTLENGS CCCEEEEECCCCCCC	18.69	23312004
281	Phosphorylation	NFVYRTDTLENGSNK CEEEEECCCCCCCCC	35.05	23312004
286	Phosphorylation	TDTLENGSNKGESAA ECCCCCCCCCCCCCC	47.12	23312004
315	Phosphorylation	INAAMALTNLAQGKD HHHHHHHHHHHCCCC	20.74	28290473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MKX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MKX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MKX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	19235719
SIN3A_HUMAN	SIN3A	physical	19235719
TBP_HUMAN	TBP	physical	19235719
TF2AA_HUMAN	GTF2A1	physical	19235719
TF2B_HUMAN	GTF2B	physical	19235719
TBL1X_HUMAN	TBL1X	physical	28514442
TBL1R_HUMAN	TBL1XR1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.