| UniProt ID | KLH25_HUMAN | |
|---|---|---|
| UniProt AC | Q9H0H3 | |
| Protein Name | Kelch-like protein 25 | |
| Gene Name | KLHL25 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 589 | |
| Subcellular Localization | ||
| Protein Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.. | |
| Protein Sequence | MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSVSVHETR ------CCCCCCCCC | 27251275 | ||
| 11 | Phosphorylation | SVHETRKSRSSTGSM CCCCCCCCCCCCCCE | 23898821 | ||
| 13 | Phosphorylation | HETRKSRSSTGSMNV CCCCCCCCCCCCEEE | 18669648 | ||
| 14 | Phosphorylation | ETRKSRSSTGSMNVT CCCCCCCCCCCEEEE | 18669648 | ||
| 15 | Phosphorylation | TRKSRSSTGSMNVTL CCCCCCCCCCEEEEE | 28348404 | ||
| 17 | Phosphorylation | KSRSSTGSMNVTLFH CCCCCCCCEEEEEEE | 27251275 | ||
| 68 | Phosphorylation | RAVLAASSRYFEAMF HHHHHHHHHHHHHHH | 28634120 | ||
| 70 | Phosphorylation | VLAASSRYFEAMFSH HHHHHHHHHHHHHHC | - | ||
| 76 | Phosphorylation | RYFEAMFSHGLRESR HHHHHHHHCCCCCCC | - | ||
| 226 | Ubiquitination | KHDLEPRKVHLPELL HCCCCCCCCCHHHHH | 29967540 | ||
| 235 | Phosphorylation | HLPELLRSVRLALLP CHHHHHHHHHHHHCC | 24670416 | ||
| 263 | Ubiquitination | LMADERTKLIMDEAL HHHHHHHHHHHHHHH | 24816145 | ||
| 284 | Phosphorylation | LQNDGVVTSPCARPR HCCCCCEECCCCCCC | 25159151 | ||
| 285 | Phosphorylation | QNDGVVTSPCARPRK CCCCCEECCCCCCCC | 25849741 | ||
| 311 | Phosphorylation | TFMCDKIYQVDHKAK EEECCCEEECCHHHH | - | ||
| 316 | Ubiquitination | KIYQVDHKAKEIIPK CEEECCHHHHHHCCC | 29967540 | ||
| 318 | Ubiquitination | YQVDHKAKEIIPKAD EECCHHHHHHCCCCC | 23000965 | ||
| 323 | Ubiquitination | KAKEIIPKADLPSPR HHHHHCCCCCCCCCC | 23000965 | ||
| 328 | Phosphorylation | IPKADLPSPRKEFSA CCCCCCCCCCHHCCH | 24719451 | ||
| 331 | Ubiquitination | ADLPSPRKEFSASAI CCCCCCCHHCCHHHC | 29967540 | ||
| 334 | Phosphorylation | PSPRKEFSASAIGCK CCCCHHCCHHHCCCE | 22461510 | ||
| 341 | Ubiquitination | SASAIGCKVYVTGGR CHHHCCCEEEEECCC | 29967540 | ||
| 343 | Phosphorylation | SAIGCKVYVTGGRGS HHCCCEEEEECCCCC | 22461510 | ||
| 345 | Phosphorylation | IGCKVYVTGGRGSEN CCCEEEEECCCCCCC | 27499020 | ||
| 406 | Phosphorylation | LAGVFPASPSVSLKQ HCCCCCCCCCCCHHH | 26657352 | ||
| 423 | Ubiquitination | KYDPGANKWMMVAPL EECCCCCCEEEEEEC | 29967540 | ||
| 461 | Ubiquitination | IHRDMVSKVQCYDPS CCHHHHCCEEEECCC | - | ||
| 475 | Ubiquitination | SENRWTIKAECPQPW CCCEEEEEEECCCCC | - | ||
| 551 | Methylation | GGYFGTQRCKTLDCY CCEECCCCCCEECCC | 24390077 | ||
| 551 | Dimethylation | GGYFGTQRCKTLDCY CCEECCCCCCEECCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLH25_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLH25_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLH25_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KLH25_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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