PPARA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPARA_RAT
• UniProt AC: P37230
• Protein Name: Peroxisome proliferator-activated receptor alpha
• Gene Name: Ppara
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 468
• Subcellular Localization: Nucleus.
• Protein Description: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)..
• Protein Sequence: MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	RICGDKASGYHYGVH EECCCCCCCCEEEEH	45.70	22817900
129	Phosphorylation	CKGFFRRTIRLKLAY CCCHHHHHHHHHHHH	13.24	22091731
142	Phosphorylation	AYDKCDRSCKIQKKN HHHCCCCCCCCCCCC	13.40	22817900
163	Phosphorylation	CRFHKCLSVGMSHNA CCHHHHHHHCCCHHH	26.54	22091731
179	Phosphorylation	RFGRMPRSEKAKLKA HCCCCCHHHHHHHHH	37.26	22817900
334	Phosphorylation	KDGMLIAYGNGFITR CCCCEEEECCCCHHH	12.25	28551015
340	Phosphorylation	AYGNGFITREFLKNL EECCCCHHHHHHHHC	23.14	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
110	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
129	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
129	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
129	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
142	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
163	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
179	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
179	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPARA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPARA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DUT_RAT	Dut	physical	8910358
NRIP1_HUMAN	NRIP1	physical	9626662

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.