DUT_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUT_RAT
• UniProt AC: P70583
• Protein Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase
• Gene Name: Dut
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm . Nucleus . Binding to PPAR induces translocation to the nucleus.
• Protein Description: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor..
• Protein Sequence: MPLLCALLRSRLQPSLLRSLTLTSAQSLSCGGSRGVRTWSARTGPGACADPAVSVSKRARAEDDASLRFVRLSEHATAPTRGSARAAGYDLYSAYDYTIPSMEKALVKTDIQIAVPSGCYGRVAPRSGLAVKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERILYPDLEEVQTLDNTERGSGGFGSTGKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	ACADPAVSVSKRARA CCCCCEECHHHHHCC	23.84	-
108	Acetylation	SMEKALVKTDIQIAV CHHHHHHCCCEEEEE	41.13	22902405
132	Acetylation	PRSGLAVKHFIDVGA CCCCCCEEEEEEECC	27.47	126957
161	Acetylation	LFNFGKEKFEVKKGD EEECCCCEEEEECCH	50.76	22902405
192	Phosphorylation	EVQTLDNTERGSGGF HHEECCCCCCCCCCC	27.07	27097102
196	Phosphorylation	LDNTERGSGGFGSTG CCCCCCCCCCCCCCC	41.80	28432305
201	Phosphorylation	RGSGGFGSTGKN--- CCCCCCCCCCCC---	31.55	27097102
202	Phosphorylation	GSGGFGSTGKN---- CCCCCCCCCCC----	53.18	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DUT_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUT_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUT_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPARA_MOUSE	Ppara	physical	8910358
PPARD_MOUSE	Ppard	physical	8910358
PPARG_MOUSE	Pparg	physical	8910358
PPARA_RAT	Ppara	physical	8910358

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.