PDK1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDK1L_HUMAN
• UniProt AC: Q8N165
• Protein Name: Serine/threonine-protein kinase PDIK1L
• Gene Name: PDIK1L
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Subcellular Localization: Nucleus .
• Protein Sequence: MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNGRMKQLIKEMLAANPQDRPDAFELELRLVQIAFKDSSWET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MVSSQPKYDLIREV -CCCCCCCHHHHHHH	43.70	-
30	Phosphorylation	YEAVIRKTSARVAVK HHHHHCCCCCCEEEE	20.12	-
31	Phosphorylation	EAVIRKTSARVAVKK HHHHCCCCCCEEEEE	19.67	-
58	Phosphorylation	LREFWALSSIKSQHP HHHHHHHHHHHCCCC	23.44	24719451
103	Ubiquitination	LVETSLKGEIAFDPR HHHHHCCCCEECCCC	36.51	22817900
109	Ubiquitination	KGEIAFDPRSAYYLW CCCEECCCCHHHEEE	26.18	22817900
166	Ubiquitination	QIIHRDLKPDNILIS CEECCCCCCCCEEEE	55.40	29967540
187	Ubiquitination	SDLEPTLKVADFGLS CCCCCCEEHHHHCHH	37.54	21906983
193	Ubiquitination	LKVADFGLSKVCSAS EEHHHHCHHHHHHCC	4.52	22817900
194	Phosphorylation	KVADFGLSKVCSASG EHHHHCHHHHHHCCC	24.34	30108239
195	Ubiquitination	VADFGLSKVCSASGQ HHHHCHHHHHHCCCC	52.91	29967540
198	Phosphorylation	FGLSKVCSASGQNPE HCHHHHHHCCCCCCC	28.58	26074081
200	Phosphorylation	LSKVCSASGQNPEEP HHHHHHCCCCCCCCC	25.31	26074081
209	Phosphorylation	QNPEEPVSVNKCFLS CCCCCCCEECEEEEE	30.59	26074081
216	Phosphorylation	SVNKCFLSTACGTDF EECEEEEECCCCCCE	8.16	26074081
217	Phosphorylation	VNKCFLSTACGTDFY ECEEEEECCCCCCEE	28.28	26074081
221	Phosphorylation	FLSTACGTDFYMAPE EEECCCCCCEEECCC	23.87	26074081
224	Phosphorylation	TACGTDFYMAPEVWE CCCCCCEEECCCHHC	8.65	27251275
251	Ubiquitination	GIIIWAMLERITFID HHHHHHHHHHCCCCC	2.86	22505724
257	Ubiquitination	MLERITFIDTETKKE HHHHCCCCCCCCHHH	4.85	22505724
268	Phosphorylation	TKKELLGSYVKQGTE CHHHHHHHHHCCCCE	27.07	24114839
271	Ubiquitination	ELLGSYVKQGTEIVP HHHHHHHCCCCEEEE	34.47	21906983
288	Ubiquitination	EALLENPKMELLIPV HHHHHCCCEEEEEEC	57.50	-
305	Ubiquitination	KSMNGRMKQLIKEML CCCCHHHHHHHHHHH	40.36	-
309	Ubiquitination	GRMKQLIKEMLAANP HHHHHHHHHHHHCCC	45.74	-
335	Ubiquitination	RLVQIAFKDSSWET- HHHHHHHCCCCCCC-	47.91	22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDK1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDK1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDK1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CA174_HUMAN	C1orf174	physical	25416956
CTSL2_HUMAN	CTDSPL2	physical	28514442
CA174_HUMAN	C1orf174	physical	28514442
FKBP5_HUMAN	FKBP5	physical	28514442
SRC_HUMAN	SRC	physical	28514442
CDC37_HUMAN	CDC37	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442
HS90B_HUMAN	HSP90AB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.