dbPTM

CA174_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CA174_HUMAN
UniProt AC	Q8IYL3
Protein Name	UPF0688 protein C1orf174
Gene Name	C1orf174
Organism	Homo sapiens (Human).
Sequence Length	243
Subcellular Localization	Nucleus .
Protein Description
Protein Sequence	MRSRKLTGAVRSSARLKARSCSAARLASAQEVAGSTSAKTACLTSSSHKATDTRTSKKFKCDKGHLVKSELQKLVPKNDSASLPKVTPETPCENEFAEGSALLPGSEAGVSVQQGAASLPLGGCRVVSDSRLAKTRDGLSVPKHSAGSGAEESNSSSTVQKQNEPGLQTEDVQKPPLQMDNSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDDDDDDDAEM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MRSRKLTGAVRSSA -CCCCHHHHHHHHHH	26.57	28258704
20	Phosphorylation	SARLKARSCSAARLA HHHHHHHHCHHHHHH	19.79	-
22	Phosphorylation	RLKARSCSAARLASA HHHHHHCHHHHHHHH	26.64	28985074
28	Phosphorylation	CSAARLASAQEVAGS CHHHHHHHHHHHCCC	34.77	25159151
35	Phosphorylation	SAQEVAGSTSAKTAC HHHHHCCCCCCCHHH	14.95	-
37	Phosphorylation	QEVAGSTSAKTACLT HHHCCCCCCCHHHHC	29.48	28555341
39	Acetylation	VAGSTSAKTACLTSS HCCCCCCCHHHHCCC	36.10	25953088
44	Phosphorylation	SAKTACLTSSSHKAT CCCHHHHCCCCCCCC	26.84	29396449
45	Phosphorylation	AKTACLTSSSHKATD CCHHHHCCCCCCCCC	19.52	29396449
46	Phosphorylation	KTACLTSSSHKATDT CHHHHCCCCCCCCCC	31.09	25159151
47	Phosphorylation	TACLTSSSHKATDTR HHHHCCCCCCCCCCC	28.86	30576142
53	Phosphorylation	SSHKATDTRTSKKFK CCCCCCCCCCCCCCC	31.34	24114839
55	Phosphorylation	HKATDTRTSKKFKCD CCCCCCCCCCCCCCC	47.17	-
63	Acetylation	SKKFKCDKGHLVKSE CCCCCCCCCHHHHHH	58.67	23749302
90	Phosphorylation	LPKVTPETPCENEFA CCCCCCCCCCCCCCC	34.15	27251275
140	Phosphorylation	AKTRDGLSVPKHSAG EECCCCCCCCCCCCC	41.73	21815630
145	Phosphorylation	GLSVPKHSAGSGAEE CCCCCCCCCCCCCCC	40.21	23401153
148	Phosphorylation	VPKHSAGSGAEESNS CCCCCCCCCCCCCCC	34.25	23401153
153	Phosphorylation	AGSGAEESNSSSTVQ CCCCCCCCCCCCCCH	33.25	25159151
155	Phosphorylation	SGAEESNSSSTVQKQ CCCCCCCCCCCCHHC	34.64	30108239
156	Phosphorylation	GAEESNSSSTVQKQN CCCCCCCCCCCHHCC	33.99	30108239
157	Phosphorylation	AEESNSSSTVQKQNE CCCCCCCCCCHHCCC	32.21	30108239
158	Phosphorylation	EESNSSSTVQKQNEP CCCCCCCCCHHCCCC	28.98	30108239
169	Phosphorylation	QNEPGLQTEDVQKPP CCCCCCCCCCCCCCC	38.91	23403867
182	Phosphorylation	PPLQMDNSVFLDDDS CCCCCCCCEEECCCC	15.24	23403867
189	Phosphorylation	SVFLDDDSNQPMPVS CEEECCCCCCCCCHH	44.34	25159151
196	Phosphorylation	SNQPMPVSRFFGNVE CCCCCCHHHEECCEE	19.94	28176443
212	Phosphorylation	MQDLPPASSSCPSMS HCCCCCCCCCCCCCC	28.67	26074081
213	Phosphorylation	QDLPPASSSCPSMSR CCCCCCCCCCCCCCH	37.76	26074081
214	Phosphorylation	DLPPASSSCPSMSRR CCCCCCCCCCCCCHH	27.79	26074081
217	Phosphorylation	PASSSCPSMSRREFR CCCCCCCCCCHHHHH	33.45	27050516
219	Phosphorylation	SSSCPSMSRREFRKM CCCCCCCCHHHHHHH	32.30	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CA174_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CA174_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CA174_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN6_HUMAN	COPS6	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CA174_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-28, AND MASSSPECTROMETRY.	17287340 [Abstract]