THAP4_HUMAN - dbPTM
THAP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THAP4_HUMAN
UniProt AC Q8WY91
Protein Name THAP domain-containing protein 4
Gene Name THAP4
Organism Homo sapiens (Human).
Sequence Length 577
Subcellular Localization
Protein Description
Protein Sequence MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLTEKKRGAGGHGRTRRKDASKATGGVRGHSSAATSRGAAGWSPSSSGNPMAKPESRRLKQAALQGEATPRAAQEAASQEQAQQALERTPGDGLATMVAGSQGKAEASATDAGDESATSSIEGGVTDKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPIDRKRLKKDVEPSCSGSSLGPDKGLAQSPPSSSLTATPQKPSQSPSAPPADVTPKPATEAVQSEHSDASPMSINEVILSASGACKLIDSLHSYCFSSRQNKSQVCCLREQVEKKNGELKSLRQRVSRSDSQVRKLQEKLDELRRVSVPYPSSLLSPSREPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHVTYKKVTP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationKGEKRAVSFHRFPLK
CCCCCCEEEECCCCC		17.85-
64PhosphorylationSEHFTKDSFSKRLED
CCCCCCHHHHHHHHH		32.7324719451
109PhosphorylationRKDASKATGGVRGHS
CCCHHHHCCCCCCCC		37.9025690035
128PhosphorylationSRGAAGWSPSSSGNP
CCCCCCCCCCCCCCC		17.6227251275
130PhosphorylationGAAGWSPSSSGNPMA
CCCCCCCCCCCCCCC		31.4628985074
131PhosphorylationAAGWSPSSSGNPMAK
CCCCCCCCCCCCCCC		45.7227080861
132PhosphorylationAGWSPSSSGNPMAKP
CCCCCCCCCCCCCCH		47.1027080861
154PhosphorylationAALQGEATPRAAQEA
HHHHCCCCHHHHHHH		14.7028985074
163PhosphorylationRAAQEAASQEQAQQA
HHHHHHHHHHHHHHH		41.1017525332
174PhosphorylationAQQALERTPGDGLAT
HHHHHHCCCCCCHHH		23.4228674419
186PhosphorylationLATMVAGSQGKAEAS
HHHHEECCCCCEECC		26.4825159151
205PhosphorylationGDESATSSIEGGVTD
CCCCCCCCCCCCCCC		21.9528985074
222PhosphorylationGISMDDFTPPGSGAC
CCCCCCCCCCCCCCH		35.2528985074
234PhosphorylationGACKFIGSLHSYSFS
CCHHEECCCEEEECC		20.3526074081
237PhosphorylationKFIGSLHSYSFSSKH
HEECCCEEEECCCCC		27.9726074081
238PhosphorylationFIGSLHSYSFSSKHT
EECCCEEEECCCCCC		11.7326074081
239PhosphorylationIGSLHSYSFSSKHTR
ECCCEEEECCCCCCC		22.9710810093
241PhosphorylationSLHSYSFSSKHTRER
CCEEEECCCCCCCCC		32.3226074081
242PhosphorylationLHSYSFSSKHTRERP
CEEEECCCCCCCCCC		26.8426074081
250PhosphorylationKHTRERPSVPREPID
CCCCCCCCCCCCCCC		51.4828555341
283PhosphorylationPDKGLAQSPPSSSLT
CCCCCCCCCCCCCCC		32.9227050516
286PhosphorylationGLAQSPPSSSLTATP
CCCCCCCCCCCCCCC		35.6225159151
287PhosphorylationLAQSPPSSSLTATPQ
CCCCCCCCCCCCCCC		34.8326074081
288PhosphorylationAQSPPSSSLTATPQK
CCCCCCCCCCCCCCC		33.7929978859
290PhosphorylationSPPSSSLTATPQKPS
CCCCCCCCCCCCCCC		30.3629978859
292PhosphorylationPSSSLTATPQKPSQS
CCCCCCCCCCCCCCC		22.4826074081
297PhosphorylationTATPQKPSQSPSAPP
CCCCCCCCCCCCCCC		50.7729978859
299PhosphorylationTPQKPSQSPSAPPAD
CCCCCCCCCCCCCCC		25.7629978859
301PhosphorylationQKPSQSPSAPPADVT
CCCCCCCCCCCCCCC		59.6729978859
308PhosphorylationSAPPADVTPKPATEA
CCCCCCCCCCCCCHH		26.5829978859
324PhosphorylationQSEHSDASPMSINEV
HCCCCCCCCCCHHHH		26.5727050516
327PhosphorylationHSDASPMSINEVILS
CCCCCCCCHHHHHHH		26.1623663014
334PhosphorylationSINEVILSASGACKL
CHHHHHHHCCCHHHH		14.8423663014
336PhosphorylationNEVILSASGACKLID
HHHHHHCCCHHHHHH		24.4423663014
344PhosphorylationGACKLIDSLHSYCFS
CHHHHHHHHHHHHHC		22.4623663014
347PhosphorylationKLIDSLHSYCFSSRQ
HHHHHHHHHHHCCCC		28.9623663014
348PhosphorylationLIDSLHSYCFSSRQN
HHHHHHHHHHCCCCC		6.1723663014
351PhosphorylationSLHSYCFSSRQNKSQ
HHHHHHHCCCCCHHH		22.5023663014
352PhosphorylationLHSYCFSSRQNKSQV
HHHHHHCCCCCHHHE		20.0323663014
356UbiquitinationCFSSRQNKSQVCCLR
HHCCCCCHHHEEHHH		33.6529967540
369UbiquitinationLREQVEKKNGELKSL
HHHHHHHHCCHHHHH		57.5924816145
374UbiquitinationEKKNGELKSLRQRVS
HHHCCHHHHHHHHHH		43.04-
385PhosphorylationQRVSRSDSQVRKLQE
HHHHHCHHHHHHHHH		31.64-
393UbiquitinationQVRKLQEKLDELRRV
HHHHHHHHHHHHHCC		48.5624816145
401PhosphorylationLDELRRVSVPYPSSL
HHHHHCCCCCCCHHH		18.6322167270
404PhosphorylationLRRVSVPYPSSLLSP
HHCCCCCCCHHHCCC		17.3728634298
406PhosphorylationRVSVPYPSSLLSPSR
CCCCCCCHHHCCCCC		27.9828634298
407PhosphorylationVSVPYPSSLLSPSRE
CCCCCCHHHCCCCCC		28.9122167270
410PhosphorylationPYPSSLLSPSREPPK
CCCHHHCCCCCCCCC		26.5625627689
412PhosphorylationPSSLLSPSREPPKMN
CHHHCCCCCCCCCCC		45.9928634298
476UbiquitinationNSFHPDTRKPMHREC
CCCCCCCCCCCCCCC		48.7624816145
532UbiquitinationIARISFAKEPHVEQI
EEEEECCCCCCHHHH		70.53-
547PhosphorylationTRKFRLNSEGKLEQT
HHHEECCCCCCEEEE		52.9328857561
554PhosphorylationSEGKLEQTVSMATTT
CCCCEEEEEEEEECC		12.7427251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THAP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THAP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THAP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
COR2A_HUMANCORO2Aphysical
26186194
AIFM1_HUMANAIFM1physical
28514442
ACTBL_HUMANACTBL2physical
28514442
HSP72_HUMANHSPA2physical
28514442
ALR_HUMANGFERphysical
28514442
ACTB_HUMANACTBphysical
28514442
HSP7C_HUMANHSPA8physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THAP4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASSSPECTROMETRY.

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