HERC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HERC6_HUMAN
• UniProt AC: Q8IVU3
• Protein Name: Probable E3 ubiquitin-protein ligase HERC6
• Gene Name: HERC6
• Organism: Homo sapiens (Human).
• Sequence Length: 1022
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates..
• Protein Sequence: MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLTQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RELQRRRTAGSPGAE HHHHHHHCCCCCHHH	33.29	28348404
20	Phosphorylation	QRRRTAGSPGAELLQ HHHHCCCCCHHHHHH	20.07	21815630
93	Ubiquitination	HSLAVCHKGRVFAWG CEEEEEECCEEEEEC	43.20	29967540
124	Phosphorylation	FTPKKIMTLNDIKII ECCCEEEEHHCEEEE	26.36	-
154	Ubiquitination	SQVFSWGKNSHGQLG CCEEECCCCCCCCCC	49.36	29967540
164	Ubiquitination	HGQLGLGKEFPSQAS CCCCCCCCCCCCCCC	62.31	21890473
164 (in isoform 3)	Ubiquitination	-	62.31	21890473
164 (in isoform 2)	Ubiquitination	-	62.31	21890473
164 (in isoform 1)	Ubiquitination	-	62.31	21890473
168	Phosphorylation	GLGKEFPSQASPQRV CCCCCCCCCCCHHHH	43.64	-
176	Ubiquitination	QASPQRVRSLEGIPL CCCHHHHHCCCCCCH	37.40	21890473
271	Phosphorylation	RSGQLGYSPTPEKRG CCCCCCCCCCCHHCC	22.09	24719451
276 (in isoform 1)	Ubiquitination	-	64.95	21890473
276 (in isoform 3)	Ubiquitination	-	64.95	21890473
276	Ubiquitination	GYSPTPEKRGPQLVE CCCCCCHHCCHHHHH	64.95	21906983
276 (in isoform 2)	Ubiquitination	-	64.95	21890473
288	Ubiquitination	LVERIDGLVSQIDCG HHHHHHHCEEEECCC	2.73	27667366
374	Ubiquitination	SSTRAPGKTLPEISR CCCCCCCCCHHHHHH	45.92	29967540
380	Phosphorylation	GKTLPEISRISQSMA CCCHHHHHHHCHHHH	23.15	-
385	Phosphorylation	EISRISQSMAEKWIA HHHHHCHHHHHHHHH	17.11	23403867
389	Methylation	ISQSMAEKWIAVKRR HCHHHHHHHHHHHCC	34.07	-
389	Trimethylation	ISQSMAEKWIAVKRR HCHHHHHHHHHHHCC	34.07	-
404 (in isoform 1)	Ubiquitination	-	47.51	21890473
404 (in isoform 2)	Ubiquitination	-	47.51	21890473
404	Ubiquitination	STEHEMAKSEIRMIF CCCHHHHHHHHHHHH	47.51	21906983
420	Phosphorylation	SPACLTASFLKKRGT CHHHHHHHHHHHCCC	26.35	24719451
458	Phosphorylation	EWISSMITTCLEDDL HHHHHHHHHHHHHHH	11.65	18452278
512	Phosphorylation	AKAVCEMSKQSLQVL HHHHHHHCHHHHHHH	12.78	22210691
513	Ubiquitination	KAVCEMSKQSLQVLK HHHHHHCHHHHHHHH	42.47	29967540
550	Phosphorylation	ISQLLHQTKTEQDHC HHHHHHHCCCCCCHH	29.23	-
551	Ubiquitination	SQLLHQTKTEQDHCN HHHHHHCCCCCCHHH	43.42	29967540
560	Ubiquitination	EQDHCNVKALLGMMK CCCHHHHHHHHHHHH	21.23	29967540
634	Ubiquitination	FNSLSKIKLLQADSH HHCHHCHHHHHCCCC	47.05	29967540
640	Phosphorylation	IKLLQADSHIKMQMS HHHHHCCCCCCCCCC	30.08	30576142
647	Phosphorylation	SHIKMQMSEKKAYML CCCCCCCCHHHHHHH	29.40	30576142
755	Ubiquitination	PAKPKPEKKRYFLFG CCCCCCCCCHHHHHH	51.59	29967540
762	Ubiquitination	KKRYFLFGMLCGLSL CCHHHHHHHHHHHHH	15.42	29967540
762 (in isoform 2)	Ubiquitination	-	15.42	21890473
770 (in isoform 2)	Ubiquitination	-	9.81	21890473
791	Ubiquitination	YKKLLDQKPSLEDLK HHHHHCCCCCHHHHH	35.92	29967540
798	Ubiquitination	KPSLEDLKELSPRLG CCCHHHHHHHCHHHH	69.77	21906983
798 (in isoform 1)	Ubiquitination	-	69.77	21890473
806 (in isoform 1)	Ubiquitination	-	53.22	21890473
806	Ubiquitination	ELSPRLGKSLQEVLD HHCHHHHHHHHHHHH	53.22	21906983
859	Phosphorylation	KRDYVSKYIDYIFNV CHHHHHHHHHHHHCC	7.48	-
867	Phosphorylation	IDYIFNVSVKAVYEE HHHHHCCCHHHHHHH	21.00	-
880	Ubiquitination	EEFQRGFYRVCEKEI HHHHCHHHHHHHHHH	12.64	29967540
880 (in isoform 2)	Ubiquitination	-	12.64	21890473
901	Ubiquitination	EELMTAIIGNTDYDW HHHHHHHHCCCCCCH	3.01	29967540
916 (in isoform 1)	Ubiquitination	-	61.43	21890473
916	Ubiquitination	KQFEQNSKYEQGYQK HHHHHCHHHHCCCCC	61.43	2190698
937	Ubiquitination	LFWKAFHKLTLDEKK HHHHHHHHCCCHHHC	36.39	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HERC6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HERC6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HERC6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HERC3_HUMAN	HERC3	physical	18535780
HERC4_HUMAN	HERC4	physical	18535780
UBQL2_HUMAN	UBQLN2	physical	18535780
NDKB_HUMAN	NME2	physical	18535780
HERC6_HUMAN	HERC6	physical	26949039
UB2L3_HUMAN	UBE2L3	physical	26949039
UB2L6_HUMAN	UBE2L6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.