SIM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIM2_HUMAN
• UniProt AC: Q14190
• Protein Name: Single-minded homolog 2
• Gene Name: SIM2
• Organism: Homo sapiens (Human).
• Sequence Length: 667
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development..
• Protein Sequence: MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYREEPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGPLGGAAPAASGLACAPGGPEAATGALRLRHPSPAATSPPGAPLPHYLGASVIITNGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	AKLLPLPSAITSQLD HHHCCCCHHHHHCCC	39.73	-
34	Phosphorylation	LPLPSAITSQLDKAS CCCCHHHHHCCCHHH	15.33	-
35	Phosphorylation	PLPSAITSQLDKASI CCCHHHHHCCCHHHH	23.72	-
115	Phosphorylation	ASVHLGLSQVELTGN EEEEECCCEEEECCC	30.31	-
186	Phosphorylation	GYKVIHCSGYLKIRQ CEEEEECCCCHHHHH	19.13	29759185
188	Phosphorylation	KVIHCSGYLKIRQYM EEEECCCCHHHHHHH	6.63	29759185
194	Phosphorylation	GYLKIRQYMLDMSLY CCHHHHHHHHHHHHH	6.98	24043423
199	Phosphorylation	RQYMLDMSLYDSCYQ HHHHHHHHHHHHHHH	24.36	24043423
201	Phosphorylation	YMLDMSLYDSCYQIV HHHHHHHHHHHHHHH	9.86	24043423
203	Phosphorylation	LDMSLYDSCYQIVGL HHHHHHHHHHHHHHH	10.93	24043423
205	Phosphorylation	MSLYDSCYQIVGLVA HHHHHHHHHHHHHHH	12.77	24043423
216	Phosphorylation	GLVAVGQSLPPSAIT HHHHCCCCCCHHHCE	36.59	24043423
220	Phosphorylation	VGQSLPPSAITEIKL CCCCCCHHHCEEEEE	30.29	24043423
223	Phosphorylation	SLPPSAITEIKLYSN CCCHHHCEEEEEECC	31.23	24043423
228	Phosphorylation	AITEIKLYSNMFMFR HCEEEEEECCCHHHH	7.94	-
229	Phosphorylation	ITEIKLYSNMFMFRA CEEEEEECCCHHHHH	32.05	-
237	Phosphorylation	NMFMFRASLDLKLIF CCHHHHHCCCEEEEE	20.40	-
343	Phosphorylation	EYKELQLSLEQVSTA EHHHHCCCHHHHHCC	19.52	-
366	Phosphorylation	ALSTSQETRKLVKPK HCCCCHHHHHHCCCC	26.01	-
471	Phosphorylation	KFGQPQGSPCEVARF CCCCCCCCHHHHHHH	22.56	25159151
500	Phosphorylation	YANPLVPSSSSPAKN ECCCCCCCCCCCCCC	35.06	28348404
501	Phosphorylation	ANPLVPSSSSPAKNP CCCCCCCCCCCCCCC	28.85	28348404
502	Phosphorylation	NPLVPSSSSPAKNPP CCCCCCCCCCCCCCC	44.68	28348404
503	Phosphorylation	PLVPSSSSPAKNPPE CCCCCCCCCCCCCCC	30.72	28348404
523	Phosphorylation	ARHSLVPSYEAPAAA CCCCCCCCCCCCHHH	28.29	26657352
524	Phosphorylation	RHSLVPSYEAPAAAV CCCCCCCCCCCHHHH	15.27	26657352
545	Phosphorylation	TAPPSFPSCGHYREE CCCCCCCCCCCCCCC	30.62	22210691
585	Phosphorylation	PECCAPPTPEAPGAP HHHCCCCCCCCCCCC	32.47	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
115	S	Phosphorylation	Kinase	ATM	Q13315	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:17360614
-	K	Ubiquitination	E3 ubiquitin ligase	ARIH1	Q9Y4X5	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARNT_HUMAN	ARNT	physical	9020169
ARNT_HUMAN	ARNT	physical	14701734
ARNT2_HUMAN	ARNT2	physical	14701734
ARNT_HUMAN	ARNT	physical	9271372
PRKN_HUMAN	PARK2	physical	15963499
ARI1_HUMAN	ARIH1	physical	15963499

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.