CBX7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBX7_HUMAN
• UniProt AC: O95931
• Protein Name: Chromobox protein homolog 7
• Gene Name: CBX7
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Nucleus .
• Protein Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity..
• Protein Sequence: MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	EQVFAVESIRKKRVR HHEEEHHHHHHHHCC	22.54	28122231
75	Acetylation	GYRKRGPKPKRLLLQ CCHHCCCCHHHHHHH	67.03	30587485
77	Acetylation	RKRGPKPKRLLLQRL HHCCCCHHHHHHHHH	62.90	30587491
85	Phosphorylation	RLLLQRLYSMDLRSS HHHHHHHHHCCCCHH	12.25	23186163
86	Phosphorylation	LLLQRLYSMDLRSSH HHHHHHHHCCCCHHC	15.48	29970186
91	Phosphorylation	LYSMDLRSSHKAKGK HHHCCCCHHCCCCCC	44.05	-
92	Phosphorylation	YSMDLRSSHKAKGKE HHCCCCHHCCCCCCC	23.67	-
104	Phosphorylation	GKEKLCFSLTCPLGS CCCEEEEEEECCCCC	23.05	28122231
106	Phosphorylation	EKLCFSLTCPLGSGS CEEEEEEECCCCCCC	15.75	28122231
111	Phosphorylation	SLTCPLGSGSPEGVV EEECCCCCCCCCCCE	43.72	28348404
113	Phosphorylation	TCPLGSGSPEGVVKA ECCCCCCCCCCCEEC	22.83	27050516
134	Phosphorylation	DKGPLVPTLPFPLRK CCCCCCCCCCCCCCC	39.31	-
167	Phosphorylation	GPNLESHSHRRELFL CCCCCCCCCHHHHHC	28.15	22617229
233	Phosphorylation	TANSITVTFREAQAA ECCEEEEEEEHHHHH	14.34	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBX7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBX7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBX7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RING1_HUMAN	RING1	physical	14647293
HDAC2_HUMAN	HDAC2	physical	19706751
RING1_HUMAN	RING1	physical	19636380
PCGF6_HUMAN	PCGF6	physical	19636380
BMI1_HUMAN	BMI1	physical	19636380
PHC2_HUMAN	PHC2	physical	19636380
RING2_HUMAN	RNF2	physical	19636380
PCGF2_HUMAN	PCGF2	physical	19636380
H31_HUMAN	HIST1H3A	physical	16537902
SUV92_HUMAN	SUV39H2	physical	21060834
HMGA1_HUMAN	HMGA1	physical	22214847
HDAC2_HUMAN	HDAC2	physical	22214847
BMI1_HUMAN	BMI1	physical	21282530
CSK21_HUMAN	CSNK2A1	physical	21282530
CSK2B_HUMAN	CSNK2B	physical	21282530
PCGF2_HUMAN	PCGF2	physical	21282530
PCGF6_HUMAN	PCGF6	physical	21282530
PHC2_HUMAN	PHC2	physical	21282530
RAD17_HUMAN	RAD17	physical	21282530
RING1_HUMAN	RING1	physical	21282530
RING2_HUMAN	RNF2	physical	21282530
C42S1_HUMAN	CDC42SE1	physical	21282530
SRBD1_HUMAN	SRBD1	physical	21282530
TPR_HUMAN	TPR	physical	21282530
UBE4A_HUMAN	UBE4A	physical	21282530
UCHL5_HUMAN	UCHL5	physical	21282530
DCAF7_HUMAN	DCAF7	physical	21282530
PCGF3_HUMAN	PCGF3	physical	21282530
PCGF1_HUMAN	PCGF1	physical	21282530
PCGF5_HUMAN	PCGF5	physical	21282530
PHC3_HUMAN	PHC3	physical	26186194
PHC2_HUMAN	PHC2	physical	26186194
UBP20_HUMAN	USP20	physical	26186194
BCOR_HUMAN	BCOR	physical	26186194
CSK2B_HUMAN	CSNK2B	physical	26186194
RING2_HUMAN	RNF2	physical	26186194
PCGF1_HUMAN	PCGF1	physical	26186194
PCGF6_HUMAN	PCGF6	physical	26186194
BMI1_HUMAN	BMI1	physical	26186194
PCGF3_HUMAN	PCGF3	physical	26186194
UBP20_HUMAN	USP20	physical	28514442
PHC3_HUMAN	PHC3	physical	28514442
PCGF1_HUMAN	PCGF1	physical	28514442
BMI1_HUMAN	BMI1	physical	28514442
PHC2_HUMAN	PHC2	physical	28514442
PCGF6_HUMAN	PCGF6	physical	28514442
PCGF3_HUMAN	PCGF3	physical	28514442
RING2_HUMAN	RNF2	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.