NFIB_HUMAN - dbPTM
NFIB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NFIB_HUMAN
UniProt AC O00712
Protein Name Nuclear factor 1 B-type
Gene Name NFIB
Organism Homo sapiens (Human).
Sequence Length 420
Subcellular Localization Nucleus.
Protein Description Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication..
Protein Sequence MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MMYSPICLTQ
-----CCCCCEECCC		15.2520068231
4Phosphorylation----MMYSPICLTQD
----CCCCCEECCCC		7.0122199227
4 (in isoform 5)Phosphorylation-7.0124719451
12 (in isoform 6)Phosphorylation-35.7229116813
41PhosphorylationLQARKRKYFKKHEKR
HHHHHHHHHHHHHHH		25.3522817900
50PhosphorylationKKHEKRMSKDEERAV
HHHHHHCCHHHHHHH		40.7720068231
58UbiquitinationKDEERAVKDELLSEK
HHHHHHHHHHHHHCC		44.49-
63PhosphorylationAVKDELLSEKPEIKQ
HHHHHHHHCCHHHHH		57.0820068231
65UbiquitinationKDELLSEKPEIKQKW
HHHHHHCCHHHHHHH		44.57-
100UbiquitinationVLTVTGKKHPCCVLS
EEEECCCCCCEEEEC		54.87-
112UbiquitinationVLSNPDQKGKIRRID
EECCCCCCCCCCHHH		70.34-
146PhosphorylationKGIPLESTDGERLMK
CCCCCCCCCHHHHHC		38.35-
150 (in isoform 6)Phosphorylation-45.6827732954
153 (in isoform 6)Phosphorylation-66.4825159151
154 (in isoform 6)Phosphorylation-13.1027732954
157 (in isoform 6)Phosphorylation-4.4621815630
158 (in isoform 6)Phosphorylation-41.0021815630
161 (in isoform 6)Phosphorylation-18.7020068231
162 (in isoform 6)Phosphorylation-2.8720068231
179 (in isoform 6)Phosphorylation-3.5125159151
182PhosphorylationELDLFLAYYVQEQDS
HHHHEEEHHHCCCCC		13.3027080861
183PhosphorylationLDLFLAYYVQEQDSG
HHHEEEHHHCCCCCC		7.0527080861
185 (in isoform 6)Phosphorylation-26.8925159151
189PhosphorylationYYVQEQDSGQSGSPS
HHHCCCCCCCCCCCC		38.1326657352
189 (in isoform 5)Phosphorylation-38.1327251275
189 (in isoform 6)Phosphorylation-38.1322210691
192PhosphorylationQEQDSGQSGSPSHND
CCCCCCCCCCCCCCC		44.7726657352
192 (in isoform 5)Phosphorylation-44.7724719451
194PhosphorylationQDSGQSGSPSHNDPA
CCCCCCCCCCCCCCC		28.6026657352
195 (in isoform 6)Phosphorylation-43.0320068231
196PhosphorylationSGQSGSPSHNDPAKN
CCCCCCCCCCCCCCC		36.3024117733
197 (in isoform 6)Phosphorylation-46.2020068231
199 (in isoform 6)Phosphorylation-38.8320068231
207PhosphorylationPAKNPPGYLEDSFVK
CCCCCCCCHHCHHHH		16.8224275569
211PhosphorylationPPGYLEDSFVKSGVF
CCCCHHCHHHHCCCC		23.6725159151
214UbiquitinationYLEDSFVKSGVFNVS
CHHCHHHHCCCCCHH		39.21-
215PhosphorylationLEDSFVKSGVFNVSE
HHCHHHHCCCCCHHH		34.5828555341
221PhosphorylationKSGVFNVSELVRVSR
HCCCCCHHHHEEEEC		26.7325159151
221 (in isoform 5)Phosphorylation-26.7324719451
226 (in isoform 6)Phosphorylation-3.3730266825
227PhosphorylationVSELVRVSRTPITQG
HHHHEEEECCCCCCC		21.6328348404
227 (in isoform 5)Phosphorylation-21.6327251275
229PhosphorylationELVRVSRTPITQGTG
HHEEEECCCCCCCCC		16.1325159151
232PhosphorylationRVSRTPITQGTGVNF
EEECCCCCCCCCCCC		23.3428348404
235PhosphorylationRTPITQGTGVNFPIG
CCCCCCCCCCCCCCC		28.3028348404
246PhosphorylationFPIGEIPSQPYYHDM
CCCCCCCCCCCCCCC		49.8224719451
246 (in isoform 5)Phosphorylation-49.8224719451
262PhosphorylationSGVNLQRSLSSPPSS
CCCCCCCCCCCCCCC		21.4630266825
262 (in isoform 5)Phosphorylation-21.4624719451
264PhosphorylationVNLQRSLSSPPSSKR
CCCCCCCCCCCCCCC		41.8830266825
264 (in isoform 5)Phosphorylation-41.8824719451
265PhosphorylationNLQRSLSSPPSSKRP
CCCCCCCCCCCCCCC		46.2330266825
265 (in isoform 5)Phosphorylation-46.2324719451
268PhosphorylationRSLSSPPSSKRPKTI
CCCCCCCCCCCCCEE		52.4530266825
269PhosphorylationSLSSPPSSKRPKTIS
CCCCCCCCCCCCEEE		38.1630266825
274PhosphorylationPSSKRPKTISIDENM
CCCCCCCEEEECCCC		23.7323663014
276PhosphorylationSKRPKTISIDENMEP
CCCCCEEEECCCCCC		29.2623927012
276 (in isoform 5)Phosphorylation-29.2624719451
283 (in isoform 6)Phosphorylation-34.5420068231
284PhosphorylationIDENMEPSPTGDFYP
ECCCCCCCCCCCCCC		23.0723927012
284 (in isoform 5)Phosphorylation-23.0724719451
286PhosphorylationENMEPSPTGDFYPSP
CCCCCCCCCCCCCCC		54.4425159151
286 (in isoform 5)Phosphorylation-54.4427251275
290PhosphorylationPSPTGDFYPSPSSPA
CCCCCCCCCCCCCCC		13.9323927012
292PhosphorylationPTGDFYPSPSSPAAG
CCCCCCCCCCCCCCC		26.4925159151
292 (in isoform 5)Phosphorylation-26.4924719451
293 (in isoform 6)Phosphorylation-34.0320873877
294PhosphorylationGDFYPSPSSPAAGSR
CCCCCCCCCCCCCCC		53.9823927012
294 (in isoform 5)Phosphorylation-53.9827251275
295PhosphorylationDFYPSPSSPAAGSRT
CCCCCCCCCCCCCCC		23.1828355574
295 (in isoform 5)Phosphorylation-23.1827251275
300PhosphorylationPSSPAAGSRTWHERD
CCCCCCCCCCCHHHC		23.0823927012
300 (in isoform 5)Phosphorylation-23.0824719451
302PhosphorylationSPAAGSRTWHERDQD
CCCCCCCCCHHHCCC		32.6323403867
307 (in isoform 6)Phosphorylation-45.9428387310
308 (in isoform 6)Phosphorylation-55.3028387310
311PhosphorylationHERDQDMSSPTTMKK
HHHCCCCCCCCCCCC		41.2629255136
312PhosphorylationERDQDMSSPTTMKKP
HHCCCCCCCCCCCCC		21.4529255136
312 (in isoform 5)Phosphorylation-21.4524719451
314PhosphorylationDQDMSSPTTMKKPEK
CCCCCCCCCCCCCCC		41.2829255136
315PhosphorylationQDMSSPTTMKKPEKP
CCCCCCCCCCCCCCC		30.3129255136
318AcetylationSSPTTMKKPEKPLFS
CCCCCCCCCCCCCCC		47.8126051181
325O-linked_GlycosylationKPEKPLFSSASPQDS
CCCCCCCCCCCCCCC		32.4531492838
325PhosphorylationKPEKPLFSSASPQDS
CCCCCCCCCCCCCCC		32.4530266825
325 (in isoform 5)Phosphorylation-32.4524719451
326PhosphorylationPEKPLFSSASPQDSS
CCCCCCCCCCCCCCC		25.9830266825
328PhosphorylationKPLFSSASPQDSSPR
CCCCCCCCCCCCCCC		25.6629255136
328 (in isoform 5)Phosphorylation-25.6624719451
332PhosphorylationSSASPQDSSPRLSTF
CCCCCCCCCCCHHCC		36.6730266825
332 (in isoform 5)Phosphorylation-36.6724719451
333PhosphorylationSASPQDSSPRLSTFP
CCCCCCCCCCHHCCC		23.4830266825
333 (in isoform 5)Phosphorylation-23.4824719451
335Asymmetric dimethylarginineSPQDSSPRLSTFPQH
CCCCCCCCHHCCCCC		43.13-
335MethylationSPQDSSPRLSTFPQH
CCCCCCCCHHCCCCC		43.1354557627
353PhosphorylationGIPGVAHSVISTRTP
CCCCCCCCCCCCCCC		16.0628348404
356PhosphorylationGVAHSVISTRTPPPP
CCCCCCCCCCCCCCC		15.0728348404
359PhosphorylationHSVISTRTPPPPSPL
CCCCCCCCCCCCCCC		39.9922167270
359 (in isoform 5)Phosphorylation-39.9924719451
364PhosphorylationTRTPPPPSPLPFPTQ
CCCCCCCCCCCCCCC		44.8622167270
364 (in isoform 5)Phosphorylation-44.8624719451
370PhosphorylationPSPLPFPTQAILPPA
CCCCCCCCCCCCCCC		30.8925850435
379PhosphorylationAILPPAPSSYFSHPT
CCCCCCCCHHCCCCC		39.5127732954
380PhosphorylationILPPAPSSYFSHPTI
CCCCCCCHHCCCCCC		29.1927732954
381PhosphorylationLPPAPSSYFSHPTIR
CCCCCCHHCCCCCCC		17.2827732954
383PhosphorylationPAPSSYFSHPTIRYP
CCCCHHCCCCCCCCC		21.9627732954
386PhosphorylationSSYFSHPTIRYPPHL
CHHCCCCCCCCCCCC		16.8027732954
388Asymmetric dimethylarginineYFSHPTIRYPPHLNP
HCCCCCCCCCCCCCH		40.14-
388MethylationYFSHPTIRYPPHLNP
HCCCCCCCCCCCCCH		40.14116265217
400MethylationLNPQDTLKNYVPSYD
CCHHHHHHHCCCCCC		48.61116265231
402 (in isoform 5)Phosphorylation-16.4927732954
405PhosphorylationTLKNYVPSYDPSSPQ
HHHHCCCCCCCCCCC		31.9320068231
405 (in isoform 5)Phosphorylation-31.9325159151
406PhosphorylationLKNYVPSYDPSSPQT
HHHCCCCCCCCCCCC		26.2920068231
406 (in isoform 5)Phosphorylation-26.2927732954
409PhosphorylationYVPSYDPSSPQTSQS
CCCCCCCCCCCCCCC		52.3220068231
409 (in isoform 5)Phosphorylation-52.3221815630
410PhosphorylationVPSYDPSSPQTSQSW
CCCCCCCCCCCCCCC		26.8120068231
410 (in isoform 5)Phosphorylation-26.8121815630
413PhosphorylationYDPSSPQTSQSWYLG
CCCCCCCCCCCCCCC		31.9218669648
413 (in isoform 5)Phosphorylation-31.9220068231
414PhosphorylationDPSSPQTSQSWYLG-
CCCCCCCCCCCCCC-		19.5720068231
414 (in isoform 5)Phosphorylation-19.5720068231
416PhosphorylationSSPQTSQSWYLG---
CCCCCCCCCCCC---		19.9129083192
418PhosphorylationPQTSQSWYLG-----
CCCCCCCCCC-----		13.5420873877
431 (in isoform 5)Phosphorylation-25159151
436Phosphorylation-----------------------
-----------------------		27251275
437 (in isoform 5)Phosphorylation-25159151
441 (in isoform 5)Phosphorylation-22210691
447 (in isoform 5)Phosphorylation-20068231
449 (in isoform 5)Phosphorylation-20068231
451 (in isoform 5)Phosphorylation-20068231
478 (in isoform 5)Phosphorylation-30266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NFIB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NFIB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NFIB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NFIC_HUMANNFICphysical
9099724
NFIX_HUMANNFIXphysical
9099724
NFIA_HUMANNFIAphysical
28514442
NFIX_HUMANNFIXphysical
28514442
NFIC_HUMANNFICphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NFIB_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264; SER-265; SER-328AND SER-332, AND MASS SPECTROMETRY.

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