NFIX_HUMAN - dbPTM
NFIX_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NFIX_HUMAN
UniProt AC Q14938
Protein Name Nuclear factor 1 X-type
Gene Name NFIX
Organism Homo sapiens (Human).
Sequence Length 502
Subcellular Localization Nucleus.
Protein Description Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication..
Protein Sequence MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKSTSTAPDGAALTPPSPSFATTGASSANRFVSIGPRDGNFLNIPQQSQSWFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MYSPYCLTQ
------CCCCCCCCC		20.5323663014
3 (in isoform 3)Phosphorylation-14.2224719451
3Phosphorylation-----MYSPYCLTQD
-----CCCCCCCCCC		14.2223663014
5Phosphorylation---MYSPYCLTQDEF
---CCCCCCCCCCCH		8.3123663014
8PhosphorylationMYSPYCLTQDEFHPF
CCCCCCCCCCCHHHH		30.3423663014
40PhosphorylationLQARKRKYFKKHEKR
HHHHHHHHHHHHHHH		25.3522817900
49PhosphorylationKKHEKRMSKDEERAV
HHHHHHCCHHHHHHH		40.7720068231
64UbiquitinationKDELLGEKPEIKQKW
HHHHCCCCHHHHHHH		46.26-
145PhosphorylationKGIPLESTDGERLYK
CCCCCCCCCCCHHCC		38.35-
231PhosphorylationVTELVRVSQTPVATA
HHHEEEEECCCEEEC		20.1322199227
233 (in isoform 3)Phosphorylation-16.5424719451
233PhosphorylationELVRVSQTPVATASG
HEEEEECCCEEECCC		16.5422199227
237PhosphorylationVSQTPVATASGPNFS
EECCCEEECCCCCCC		22.9122199227
239PhosphorylationQTPVATASGPNFSLA
CCCEEECCCCCCCHH		50.8928348404
244 (in isoform 3)Phosphorylation-29.3224719451
244PhosphorylationTASGPNFSLADLESP
ECCCCCCCHHHCCCC		29.3222199227
250PhosphorylationFSLADLESPSYYNIN
CCHHHCCCCCCEECC		26.8321712546
250 (in isoform 3)Phosphorylation-26.8324719451
252PhosphorylationLADLESPSYYNINQV
HHHCCCCCCEECCEE		49.9122199227
253PhosphorylationADLESPSYYNINQVT
HHCCCCCCEECCEEE		12.1517360941
254PhosphorylationDLESPSYYNINQVTL
HCCCCCCEECCEEEE		17.5722199227
265 (in isoform 3)Phosphorylation-28.9424719451
265PhosphorylationQVTLGRRSITSPPST
EEEECCCCCCCCCCC		28.9423401153
267PhosphorylationTLGRRSITSPPSTST
EECCCCCCCCCCCCC		36.1130266825
268 (in isoform 3)Phosphorylation-32.8924719451
268PhosphorylationLGRRSITSPPSTSTT
ECCCCCCCCCCCCCC		32.8929255136
271 (in isoform 3)Phosphorylation-38.0724719451
271PhosphorylationRSITSPPSTSTTKRP
CCCCCCCCCCCCCCC		38.0730266825
272PhosphorylationSITSPPSTSTTKRPK
CCCCCCCCCCCCCCC		35.5530266825
273PhosphorylationITSPPSTSTTKRPKS
CCCCCCCCCCCCCCC		38.1223403867
274PhosphorylationTSPPSTSTTKRPKSI
CCCCCCCCCCCCCCC		36.1023403867
275PhosphorylationSPPSTSTTKRPKSID
CCCCCCCCCCCCCCC		25.4823403867
279SumoylationTSTTKRPKSIDDSEM
CCCCCCCCCCCHHHC		65.1728112733
280PhosphorylationSTTKRPKSIDDSEME
CCCCCCCCCCHHHCC		33.6522167270
280 (in isoform 3)Phosphorylation-33.6524719451
284PhosphorylationRPKSIDDSEMESPVD
CCCCCCHHHCCCCCC		34.7923401153
284 (in isoform 3)Phosphorylation-34.7924719451
288 (in isoform 3)Phosphorylation-28.9824719451
288PhosphorylationIDDSEMESPVDDVFY
CCHHHCCCCCCCCCC		28.9830266825
295PhosphorylationSPVDDVFYPGTGRSP
CCCCCCCCCCCCCCC		10.7030266825
298PhosphorylationDDVFYPGTGRSPAAG
CCCCCCCCCCCCCCC		25.5623927012
301 (in isoform 3)Phosphorylation-21.8924719451
301PhosphorylationFYPGTGRSPAAGSSQ
CCCCCCCCCCCCCCC		21.8923401153
306PhosphorylationGRSPAAGSSQSSGWP
CCCCCCCCCCCCCCC		22.0723927012
307 (in isoform 2)Phosphorylation-32.9122210691
307 (in isoform 3)Phosphorylation-32.9124719451
307PhosphorylationRSPAAGSSQSSGWPN
CCCCCCCCCCCCCCC		32.9123927012
309PhosphorylationPAAGSSQSSGWPNDV
CCCCCCCCCCCCCCC		32.5323927012
310PhosphorylationAAGSSQSSGWPNDVD
CCCCCCCCCCCCCCC		36.9223927012
322PhosphorylationDVDAGPASLKKSGKL
CCCCCCCHHHCCCCC		43.8023927012
326PhosphorylationGPASLKKSGKLDFCS
CCCHHHCCCCCCHHH		39.3030576142
336PhosphorylationLDFCSALSSQGSSPR
CCHHHHHHCCCCCCC		21.9721712546
337PhosphorylationDFCSALSSQGSSPRM
CHHHHHHCCCCCCCE		39.1419690332
340PhosphorylationSALSSQGSSPRMAFT
HHHHCCCCCCCEEEC		29.5429743597
341 (in isoform 3)Phosphorylation-24.2924719451
341PhosphorylationALSSQGSSPRMAFTH
HHHCCCCCCCEEECC		24.2929255136
343Asymmetric dimethylarginineSSQGSSPRMAFTHHP
HCCCCCCCEEECCCC		30.89-
343MethylationSSQGSSPRMAFTHHP
HCCCCCCCEEECCCC		30.89-
347PhosphorylationSSPRMAFTHHPLPVL
CCCCEEECCCCCCEE		15.1023927012
361PhosphorylationLAGVRPGSPRATASA
EECCCCCCCCCCHHH		17.5629255136
361 (in isoform 3)Phosphorylation-17.5624719451
365PhosphorylationRPGSPRATASALHFP
CCCCCCCCHHHCCCC		23.5622199227
367PhosphorylationGSPRATASALHFPST
CCCCCCHHHCCCCCC		27.3222199227
373PhosphorylationASALHFPSTSIIQQS
HHHCCCCCCCHHCCC		33.5728857561
374PhosphorylationSALHFPSTSIIQQSS
HHCCCCCCCHHCCCC		24.9624719451
374 (in isoform 3)Phosphorylation-24.9624719451
375PhosphorylationALHFPSTSIIQQSSP
HCCCCCCCHHCCCCC		23.2528857561
380PhosphorylationSTSIIQQSSPYFTHP
CCCHHCCCCCCCCCC		19.5322199227
380 (in isoform 3)Phosphorylation-19.5324719451
381PhosphorylationTSIIQQSSPYFTHPT
CCHHCCCCCCCCCCC		21.2022199227
383PhosphorylationIIQQSSPYFTHPTIR
HHCCCCCCCCCCCEE		24.0622199227
385PhosphorylationQQSSPYFTHPTIRYH
CCCCCCCCCCCEECC		22.5422199227
388PhosphorylationSPYFTHPTIRYHHHH
CCCCCCCCEECCCCC		15.52-
390MethylationYFTHPTIRYHHHHGQ
CCCCCCEECCCCCCC		27.49-
390Asymmetric dimethylarginineYFTHPTIRYHHHHGQ
CCCCCCEECCCCCCC		27.49-
399PhosphorylationHHHHGQDSLKEFVQF
CCCCCCCCHHHHHHH		33.1928348404
401 (in isoform 6)Phosphorylation-53.7228348404
404 (in isoform 6)Phosphorylation-4.5328348404
408 (in isoform 6)Phosphorylation-3.0328348404
408 (in isoform 5)Phosphorylation-3.0328348404
409 (in isoform 3)Phosphorylation-39.4428348404
411 (in isoform 5)Phosphorylation-19.8528348404
412 (in isoform 6)Phosphorylation-32.4928348404
412 (in isoform 3)Phosphorylation-32.4928348404
415 (in isoform 5)Phosphorylation-19.7528348404
416 (in isoform 3)Phosphorylation-28.5828348404
419 (in isoform 5)Phosphorylation-48.7928348404
420 (in isoform 3)Phosphorylation-49.7528348404
424 (in isoform 6)Phosphorylation-50.6724719451
426 (in isoform 6)Phosphorylation-37.0528348404
431 (in isoform 5)Phosphorylation-11.4224719451
432 (in isoform 6)Phosphorylation-8.2124719451
432 (in isoform 3)Phosphorylation-8.2124719451
433 (in isoform 5)Phosphorylation-5.8828348404
434 (in isoform 3)Phosphorylation-41.3128348404
439 (in isoform 5)Phosphorylation-9.7124719451
440 (in isoform 3)Phosphorylation-18.8124719451
463PhosphorylationAPDGAALTPPSPSFA
CCCCCCCCCCCCCCC		28.5527251275
466PhosphorylationGAALTPPSPSFATTG
CCCCCCCCCCCCCCC		34.0927251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NFIX_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NFIX_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NFIX_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HDAC1_HUMANHDAC1physical
11896613
RB_HUMANRB1physical
11896613
SKI_HUMANSKIgenetic
9380514
PIR_HUMANPIRphysical
9079676
JMJD6_HUMANJMJD6physical
23455924
NFIX_HUMANNFIXphysical
25416956
QRIC1_HUMANQRICH1physical
25416956
ZN614_HUMANZNF614physical
25416956
Drug and Disease Associations
Kegg Disease
OMIM Disease
614753Sotos syndrome 2 (SOTOS2)
602535Marshall-Smith syndrome (MRSHSS)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NFIX_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND MASSSPECTROMETRY.

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