dbPTM

ERG24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ERG24_HUMAN
UniProt AC	O76062
Protein Name	Delta(14)-sterol reductase
Gene Name	TM7SF2
Organism	Homo sapiens (Human).
Sequence Length	418
Subcellular Localization	Microsome membrane Multi-pass membrane protein. Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Involved in the conversion of lanosterol to cholesterol..
Protein Sequence	MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	PGLEVLWSPRALLLW CCCHHHCCHHHHHHH	10.59	24719451
91	Ubiquitination	VAEGQELKDKSRLRY HHCCCCCCCHHCCCC	63.46	-
158	Phosphorylation	KAQVAPVSALAPGGN HHHCCCHHHCCCCCC	19.26	-
311	Ubiquitination	FRGANSQKNTFRKNP ECCCCCCCCCCCCCC	58.75	-
319	Phosphorylation	NTFRKNPSDPRVAGL CCCCCCCCCCCCCCC	70.42	24719451
333	Phosphorylation	LETISTATGRKLLVS CEEEECHHCCCEEEC	37.29	22210691
397	Ubiquitination	DERQCLQKYGLAWQE CHHHHHHHHCCHHHH	28.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ERG24_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ERG24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ERG24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ERG24_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ERG24_HUMAN

Related Literatures of Post-Translational Modification