NRDE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRDE2_HUMAN
• UniProt AC: Q9H7Z3
• Protein Name: Protein NRDE2 homolog
• Gene Name: NRDE2
• Organism: Homo sapiens (Human).
• Sequence Length: 1164
• Protein Sequence: MALFPAFAGLSEAPDGGSSRKELDWLSNPSFCVGSITSLSQQTEAAPAHVSEGLPLTRSHLKSESSDESDTNKKLKQTSRKKKKEKKKKRKHQHHKKTKRKHGPSSSSRSETDTDSEKDKPSRGVGGSKKESEEPNQGNNAAADTGHRFVWLEDIQAVTGETFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSTEKKHSRKQVERYFTKKSVGLMNIDGVAISSKTEPPSSEPISFIPVKDLEDAAPVTTWLNPLGIYDQSTTHWLQGQGPPEQESKQPDAQPDSESAALKAKVEEFNRRVRENPRDTQLWMAFVAFQDEVMKSPGLYAIEEGEQEKRKRSLKLILEKKLAILERAIESNQSSVDLKLAKLKLCTEFWEPSTLVKEWQKLIFLHPNNTALWQKYLLFCQSQFSTFSISKIHSLYGKCLSTLSAVKDGSILSHPALPGTEEAMFALFLQQCHFLRQAGHSEKAISLFQAMVDFTFFKPDSVKDLPTKGQVEFFEPFWDSGEPRAGEKGARGWKAWMHQQERGGWVVINPDEDDDEPEEDDQEIKDKTLPRWQIWLAAERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSHDLQFQLVEAFLQFLGVPSGFTPPASCLYLAMDENSIFDNGLYDEKPLTFFNPLFSGASCVGRMDRLGYPRWTRGQNREGEEFIRNVFHLVMPLFSGKEKSQLCFSWLQYEIAKVIWCLHTKNKKRLKSQGKNCKKLAKNLLKEPENCNNFCLWKQYAHLEWLLGNTEDARKVFDTALGMAGSRELKDSDLCELSLLYAELEVELSPEVRRAATARAVHILTKLTESSPYGPYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTDSCSRLISLAKCFMLFQYLTIGIDAAVQIYEQVFAKLNSSVFPEGSGEGDSASSQSWTSVLEAITLMHTSLLRFHMKVSVYPLAPLREALSQALKLYPGNQVLWRSYVQIQNKSHSASKTRRFFDTITRSAKPLEPWLFAIEAEKLRKRLVETVQRLDGREIHATIPETGLMHRIQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQNCPWAKVLYLDAVEYFPDEMQEILDLMTEKELRVRLPLEELELLLED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALFPAFAG ------CCCCCCCCC		22223895
59	Phosphorylation	EGLPLTRSHLKSESS CCCCCCHHHHCCCCC		28102081
62	Acetylation	PLTRSHLKSESSDES CCCHHHHCCCCCCCC		20167786
63	Phosphorylation	LTRSHLKSESSDESD CCHHHHCCCCCCCCH		27732954
65	Phosphorylation	RSHLKSESSDESDTN HHHHCCCCCCCCHHH		27732954
66	Phosphorylation	SHLKSESSDESDTNK HHHCCCCCCCCHHHH		27732954
69	Phosphorylation	KSESSDESDTNKKLK CCCCCCCCHHHHHHH		27732954
71	Phosphorylation	ESSDESDTNKKLKQT CCCCCCHHHHHHHHH		25072903
76	Acetylation	SDTNKKLKQTSRKKK CHHHHHHHHHHHHHH		20167786
97	Acetylation	RKHQHHKKTKRKHGP HHHHHHHHHHHHCCC		7374315
97	Methylation	RKHQHHKKTKRKHGP HHHHHHHHHHHHCCC		-
99	Methylation	HQHHKKTKRKHGPSS HHHHHHHHHHCCCCC		-
101	Methylation	HHKKTKRKHGPSSSS HHHHHHHHCCCCCCC		-
105	Phosphorylation	TKRKHGPSSSSRSET HHHHCCCCCCCCCCC		28985074
106	Phosphorylation	KRKHGPSSSSRSETD HHHCCCCCCCCCCCC		29449344
107	Phosphorylation	RKHGPSSSSRSETDT HHCCCCCCCCCCCCC		29449344
108	Phosphorylation	KHGPSSSSRSETDTD HCCCCCCCCCCCCCC		29449344
110	Phosphorylation	GPSSSSRSETDTDSE CCCCCCCCCCCCCCC		29449344
112	Phosphorylation	SSSSRSETDTDSEKD CCCCCCCCCCCCCCC		29449344
114	Phosphorylation	SSRSETDTDSEKDKP CCCCCCCCCCCCCCC		28985074
116	Phosphorylation	RSETDTDSEKDKPSR CCCCCCCCCCCCCCC		29449344
130	Ubiquitination	RGVGGSKKESEEPNQ CCCCCCCCCCCCCCC		24816145
201	Ubiquitination	CLGINPKKQCISWEG CCCCCCCCCEEECCC		22505724
210	Phosphorylation	CISWEGTSTEKKHSR EEECCCCCCCCHHCH		25627689
240	Phosphorylation	NIDGVAISSKTEPPS EECEEEEECCCCCCC		-
241	Phosphorylation	IDGVAISSKTEPPSS ECEEEEECCCCCCCC		-
252	Phosphorylation	PPSSEPISFIPVKDL CCCCCCCCEEECCCH		28555341
306	Ubiquitination	QPDSESAALKAKVEE CCCCHHHHHHHHHHH		24816145
310	Ubiquitination	ESAALKAKVEEFNRR HHHHHHHHHHHHHHH		-
341	Phosphorylation	FQDEVMKSPGLYAIE HHHHHHHCCCEEECC		21815630
366	Ubiquitination	LKLILEKKLAILERA HHHHHHHHHHHHHHH		33845483
384	Ubiquitination	NQSSVDLKLAKLKLC CCCCHHHHHHHHHHH		29967540
399	Phosphorylation	TEFWEPSTLVKEWQK HHCCCHHHHHHHHHH		-
443	Ubiquitination	KIHSLYGKCLSTLSA HHHHHHHHHHHHHHH		29967540
513	Ubiquitination	SVKDLPTKGQVEFFE CHHCCCCCCCEEEEC		29967540
570	Ubiquitination	EEDDQEIKDKTLPRW CCCCHHHHHCCCCHH		24816145
623	Phosphorylation	LFDDIGQSLIRLSSH HHHHHHHHHHHHHHH		24719451
698	Phosphorylation	GRMDRLGYPRWTRGQ CCCHHCCCCCCCCCC		26074081
702	Phosphorylation	RLGYPRWTRGQNREG HCCCCCCCCCCCHHH		26074081
772	Ubiquitination	KLAKNLLKEPENCNN HHHHHHHCCCCCCCC		29967540
801	Ubiquitination	GNTEDARKVFDTALG CCHHHHHHHHHHHHH		24816145
805	Phosphorylation	DARKVFDTALGMAGS HHHHHHHHHHHHCCC		24719451
809	Sulfoxidation	VFDTALGMAGSRELK HHHHHHHHCCCCCCC		21406390
811	Ubiquitination	DTALGMAGSRELKDS HHHHHHCCCCCCCCC		24816145
851	Phosphorylation	ARAVHILTKLTESSP HHHHHHHHHHCCCCC		29396449
854	Phosphorylation	VHILTKLTESSPYGP HHHHHHHCCCCCCCC		25072903
856	Phosphorylation	ILTKLTESSPYGPYT HHHHHCCCCCCCCCC		25072903
857	Phosphorylation	LTKLTESSPYGPYTG HHHHCCCCCCCCCCC		25072903
859	Phosphorylation	KLTESSPYGPYTGQV HHCCCCCCCCCCCCE		25072903
862	Phosphorylation	ESSPYGPYTGQVLAV CCCCCCCCCCCEEEH		25072903
863	Phosphorylation	SSPYGPYTGQVLAVH CCCCCCCCCCEEEHH		25072903
873	Acetylation	VLAVHILKARKAYEH EEEHHHHHHHHHHHH		26051181
967	Phosphorylation	AITLMHTSLLRFHMK HHHHHHHHHHHHCCC		24719451
1029	Ubiquitination	DTITRSAKPLEPWLF HHHCCCCCCCCCHHH		-
1095	Phosphorylation	CPLLWRMYLNFLVSL CHHHHHHHHHHHHHC		29396449
1101	Phosphorylation	MYLNFLVSLGNKERS HHHHHHHHCCCCHHC		29396449
1108	Phosphorylation	SLGNKERSKGVFYKA HCCCCHHCCCHHHHH		29396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRDE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRDE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRDE2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NRDE2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.