C1QB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C1QB_HUMAN
• UniProt AC: P02746
• Protein Name: Complement C1q subcomponent subunit B
• Gene Name: C1QB
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Secreted.
• Protein Description: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes..
• Protein Sequence: MMMKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Pyrrolidone_carboxylic_acid	LIDISQAQLSCTGPP HHCHHHHHHHCCCCC	26.69	708376
28	Pyrrolidone_carboxylic_acid	LIDISQAQLSCTGPP HHCHHHHHHHCCCCC	26.69	708376
28	Pyrrolidone_carboxylic_acid	LIDISQAQLSCTGPP HHCHHHHHHHCCCCC	26.69	-
35	Hydroxylation	QLSCTGPPAIPGIPG HHHCCCCCCCCCCCC	44.13	486087
38	Hydroxylation	CTGPPAIPGIPGIPG CCCCCCCCCCCCCCC	36.45	486087
41	Hydroxylation	PPAIPGIPGIPGTPG CCCCCCCCCCCCCCC	40.34	486087
53	Hydroxylation	TPGPDGQPGTPGIKG CCCCCCCCCCCCCCC	54.90	486087
56	Hydroxylation	PDGQPGTPGIKGEKG CCCCCCCCCCCCCCC	48.72	486087
59	Hydroxylation	QPGTPGIKGEKGLPG CCCCCCCCCCCCCCC	67.92	486087
62	Hydroxylation	TPGIKGEKGLPGLAG CCCCCCCCCCCCCCC	74.54	486087
65	Hydroxylation	IKGEKGLPGLAGDHG CCCCCCCCCCCCCCC	44.41	486087
77	Hydroxylation	DHGEFGEKGDPGIPG CCCCCCCCCCCCCCC	69.83	486087
77	Trimethylation	DHGEFGEKGDPGIPG CCCCCCCCCCCCCCC	69.83	-
77	Methylation	DHGEFGEKGDPGIPG CCCCCCCCCCCCCCC	69.83	-
83	Hydroxylation	EKGDPGIPGNPGKVG CCCCCCCCCCCCCCC	42.28	486087
86	Hydroxylation	DPGIPGNPGKVGPKG CCCCCCCCCCCCCCC	50.31	486087
88	Trimethylation	GIPGNPGKVGPKGPM CCCCCCCCCCCCCCC	45.32	-
88	Methylation	GIPGNPGKVGPKGPM CCCCCCCCCCCCCCC	45.32	-
92	Methylation	NPGKVGPKGPMGPKG CCCCCCCCCCCCCCC	70.49	-
92	Trimethylation	NPGKVGPKGPMGPKG CCCCCCCCCCCCCCC	70.49	-
92	Hydroxylation	NPGKVGPKGPMGPKG CCCCCCCCCCCCCCC	70.49	486087
98	Hydroxylation	PKGPMGPKGGPGAPG CCCCCCCCCCCCCCC	71.43	486087
101	Hydroxylation	PMGPKGGPGAPGAPG CCCCCCCCCCCCCCC	44.43	486087
104	Hydroxylation	PKGGPGAPGAPGPKG CCCCCCCCCCCCCCC	45.45	486087
107	Hydroxylation	GPGAPGAPGPKGESG CCCCCCCCCCCCCCC	66.58	486087
110	Hydroxylation	APGAPGPKGESGDYK CCCCCCCCCCCCCCH	79.72	486087
125	Phosphorylation	ATQKIAFSATRTINV HCEEEEEEEECEECC	21.51	-
127	Phosphorylation	QKIAFSATRTINVPL EEEEEEEECEECCCC	27.44	-
129	Phosphorylation	IAFSATRTINVPLRR EEEEEECEECCCCCC	16.73	-
168	Phosphorylation	TCKVPGLYYFTYHAS EEECCEEEEEEEEEC	11.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C1QB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C1QB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C1QB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR27_HUMAN	EDA2R	physical	21988832
TF65_HUMAN	RELA	physical	21988832
AT12A_HUMAN	ATP12A	physical	26186194
MAP2_HUMAN	METAP2	physical	26186194
GT252_HUMAN	COLGALT2	physical	26186194
SC65_HUMAN	P3H4	physical	26186194
FINC_HUMAN	FN1	physical	26186194
CO4A2_HUMAN	COL4A2	physical	26186194
UBP30_HUMAN	USP30	physical	26186194
GLPK_HUMAN	GK	physical	26186194
CF120_HUMAN	C6orf120	physical	26186194
P3H3_HUMAN	LEPREL2	physical	26186194
VHL_HUMAN	VHL	physical	26186194
VHL_HUMAN	VHL	physical	28514442
FINC_HUMAN	FN1	physical	28514442
UBP30_HUMAN	USP30	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
P3H3_HUMAN	LEPREL2	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
DMWD_HUMAN	DMWD	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613652: Complement component C1q deficiency (C1QD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.