TNR27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR27_HUMAN
• UniProt AC: Q9HAV5
• Protein Name: Tumor necrosis factor receptor superfamily member 27
• Gene Name: EDA2R
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Membrane; Single-pass type III membrane protein.
• Protein Description: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6..
• Protein Sequence: MDCQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQSCITCAVINRVQKVNCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVEADTPTVPPQEATLVALVSSLLVVFTLAFLGLFFLYCKQFFNRHCQRGGLLQFEADKTAKEESLFPVPPSKETSAESQVSENIFQTQPLNPILEDDCSSTSGFPTQESFTMASCTSESHSHWVHSPIECTELDLQKFSSSASYTGAETLGGNTVESTGDRLELNVPFEVPSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	N-linked_Glycosylation	INRVQKVNCTATSNA HCCEEECCCCCCCCC	25.18	UniProtKB CARBOHYD
79	Phosphorylation	KVNCTATSNAVCGDC ECCCCCCCCCCCCCH	21.96	-
91	Phosphorylation	GDCLPRFYRKTRIGG CCHHHHHHHHCCCCC	16.69	-
182	Acetylation	LLQFEADKTAKEESL EEEEECCCCCCHHHC	58.38	7933725
185	Acetylation	FEADKTAKEESLFPV EECCCCCCHHHCCCC	68.21	7933735
235	Phosphorylation	FPTQESFTMASCTSE CCCCCEEEEEECCCC	22.55	22468782
238	Phosphorylation	QESFTMASCTSESHS CCEEEEEECCCCCCC	13.70	22468782
240	Phosphorylation	SFTMASCTSESHSHW EEEEEECCCCCCCCC	32.79	22468782
278	Phosphorylation	AETLGGNTVESTGDR CCCCCCCEEEECCCC	29.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR27_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF3_HUMAN	TRAF3	physical	12270937
TRAF6_HUMAN	TRAF6	physical	12270937
TRAF3_HUMAN	TRAF3	physical	15280356
TRAF6_HUMAN	TRAF6	physical	15280356
HSDL1_HUMAN	HSDL1	physical	26186194
ICAM1_HUMAN	ICAM1	physical	26186194
TRAF2_HUMAN	TRAF2	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
KITH_HUMAN	TK1	physical	26186194
TRAF3_HUMAN	TRAF3	physical	26186194
TRAF6_HUMAN	TRAF6	physical	26186194
TRAF1_HUMAN	TRAF1	physical	26186194
TRAF3_HUMAN	TRAF3	physical	28514442
TRAF6_HUMAN	TRAF6	physical	28514442
ICAM1_HUMAN	ICAM1	physical	28514442
TRAF1_HUMAN	TRAF1	physical	28514442
HSDL1_HUMAN	HSDL1	physical	28514442
KITH_HUMAN	TK1	physical	28514442
TRAF2_HUMAN	TRAF2	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.