PHO_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHO_DROME
• UniProt AC: Q8ST83
• Protein Name: Polycomb protein PHO
• Gene Name: pho
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 520
• Subcellular Localization: Nucleus .
• Protein Description: Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair..
• Protein Sequence: MAYERFGIILQSEQYDEDIGNTKVNQKMNEGNHYDLHRKNAFDRIIHSESKKGDNVINYNIHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQSEDTSANYVKVELQDSVTENHVPFVVYAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
337	Phosphorylation	HQDNTDSTGCGEMNL CCCCCCCCCCCEEEC	39.02	22668510
409	Phosphorylation	KRHQLVHTGEKPFQC CCCCCCCCCCCCEEE	39.29	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHO_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHO_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A6_DROME	a6	physical	14605208
INO80_DROME	Ino80	physical	16618800
SMBT_DROME	Sfmbt	physical	16618800
ARP5_DROME	Arp5	physical	16618800
ARP8_DROME	Arp8	physical	16618800
RUVB2_DROME	rept	physical	16618800
RUVB1_DROME	pont	physical	16618800
ACT1_DROME	Act5C	physical	16618800
ESC_DROME	esc	physical	11581156
ESC_DROME	esc	physical	15175158
SMBT_DROME	Sfmbt	physical	21415365
SMBT_DROME	Sfmbt	physical	24186981
EZ_DROME	E(z)	physical	11581156
EZ_DROME	E(z)	physical	15175158
PC_DROME	Pc	physical	11581156
PC_DROME	Pc	physical	21415365
SF3B5_DROME	CG11985	physical	25242320
SOSSC_DROME	CG42374	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.