ARP5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP5_DROME
• UniProt AC: Q9VEC3
• Protein Name: Actin-related protein 5
• Gene Name: Arp5 {ECO:0000303|PubMed:16618800}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 648
• Subcellular Localization: Nucleus .
• Protein Description: Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair..
• Protein Sequence: MAGKRVLVIDNGSYECRVGWSDSKEPDLRFRNVLTKPRKDRKKEAAASEGSASQTTVEQSAEIQVGNDITNIEAVRAHLKSPFERNVITNWNHQEQIFDYIFTKMGFDGQDKIDHPIILTEALANPNFCRQQMNELLFECYGIPSVSYGIDALYSWKHHQQKQKNISDALIISFGYSTTHVIPVLDGKLQLEHVRRLNVGGYHIITYLFRLMQMKYPVHLNAITISRMEKLVHEHCHIAVDYKEELVQWAQMDYYDEHIMKIQLPYNAVTATNAMLTAEQKQEKRRELAHRLLDIKKNREQEKLREDEQQLFVYNKLRQLYEQKKLDKFERALQQQQIGTLEDLDSLIATINSRIKRAQERAQSGPRPSKQQERLNKMPKPPEGMSQADWLAELQGKREKILGRKQARQQQRSEQAKRHTHAAQERMRIISSLAKNEKRRKANGEEEDDGFGMNDNDWDVYKRINRYNDDSDSDADNEKLMQFDKILNHYDANTDGNSNVPPQSAAENYQLHFGVENIRVPEVLFQPSMIGCSEAGLAELIAFVLKLFPAAEQQRLVEHVYLTGGCAQFKGLKERLIKELMEMRPFQSKFAIYESDEPTLSAWLGACVHAGEPTFGQTLTTRQDHQEHGREFFREHTASNIFYPTPKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	AVRAHLKSPFERNVI HHHHHCCCCHHHCCC	40.98	19429919
471	Phosphorylation	INRYNDDSDSDADNE HHCCCCCCCCCCCHH	41.71	19429919
473	Phosphorylation	RYNDDSDSDADNEKL CCCCCCCCCCCHHHH	38.35	19429919
637	Phosphorylation	REFFREHTASNIFYP HHHHHHHCCCCCCCC	27.33	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN4_DROME	CSN4	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-471 AND SER-473, ANDMASS SPECTROMETRY.
PubMed: 18327897